Sulfhydryl-functionalized polymeric compositions for medical devices
View Patent ↗The present disclosure provides sulfhydryl-modified polymer foams, which may be used for wound dressing materials. For example, the modified materials can include free sulfhydryl group, which can serve as a linker to attach biologically active molecules. For example, sulfhydryl groups can be used to conjugate biologically active polypeptides and/or metals to foam polymers. Methods for using sulfhydryl-modified polymers, such as for wound dressings, are also provided.
1. An open cell foam comprising a sulfhydryl-functional polyurethane polymer comprising a sulfhydryl group available for chemical reaction wherein the sulfhydryl group is provided by an adapter covalently attached to the polyurethane polymer, wherein the adapter has the structure of formula (I):
wherein one or both of R1 and R2 forms a first covalent bond with the material and the other is OH, OCH3, O(CH2)1-4)CH3, or a covalent bond with the polymer; n is 1-30; and R 3 is H, further comprising a biologically active agent covalently attached to the sulfhydryl group or through a disulfide group derived from the sulfhydryl group.
2. The open cell foam of claim 1 , further comprising a crosslinker covalently attached to the adapter.
3. The open cell foam of claim 2 , further comprising a biologically active agent covalently attached to the crosslinker.
4. The open cell foam of claim 1 , wherein the biologically active agent is a therapeutic agent selected from the group consisting of a peptide, polypeptide, peptide matrix, protein matrix, carbohydrate, oligonucleotide, antimicrobial, small molecule, nanoparticle, nanobot, aliphatic hydrocarbon chain, surfactants, alginate, aptamer, and a combination thereof.
5. The open cell foam of claim 1 , wherein the biologically active agent comprises a metal cation in the +1, or +2 state.
6. The open cell foam of claim 1 , wherein the biologically active agent is a therapeutic agent selected from the group consisting of a peptide, polypeptide, peptide matrix, protein matrix, carbohydrate, oligonucleotide, antimicrobial, small molecule, nanoparticle, nanobot, aliphatic hydrocarbon chain, surfactants, alginate, aptamer, and a combination thereof.
7. The open cell foam of claim 2 , wherein the biologically active agent is a therapeutic agent selected from the group consisting of a peptide, polypeptide, peptide matrix, protein matrix, carbohydrate, oligonucleotide, antimicrobial, small molecule, nanoparticle, nanobot, aliphatic hydrocarbon chain, surfactants, alginate, aptamer, and a combination thereof.
8. A wound dressing comprising the foam of claim 1 .
9. A method for treating a wound comprising contacting a wound site with a wound dressing of claim 1 .
10. The method of claim 9 , wherein the method further comprises applying negative pressure to the wound site.
11. The method of claim 10 , wherein the method further comprises applying wound instillation solution to the wound site.
12. The method of claim 11 , wherein the instillation solution includes one or more agents that modulate the release of the biologically active agent.