IP Library › Granted Patent US 9,682,988
Granted Patent B2
US 9,682,988 · App. 14/439,473 · Granted Jun 20, 2017

Solid salt form of α-6-mPEG

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Quick Facts
Patent No.
US 9,682,988
App. No.
14/439,473
Granted
Jun 20, 2017
Kind
B2
Abstract

Solid forms of certain opioid agonists are provided herein. Methods of preparing the solid forms, methods of using the solid forms, and pharmaceutical compositions comprising the solid forms are also provided herein.

Claims (5)

1. A solid salt form of α-6-mPEG 6 -O-hydroxycodone phosphate having X-ray powder diffraction peak values comprising: 2.0±0.2, 15.0±0.2, and 17.0±0.2 degrees two theta, when measured with Cu Kα radiation.

2. A method of treating pain in a patient comprising administering the solid salt form of α-6-mPEG 6 -O-hydroxycodone of claim 1 .

3. The method of claim 2 , wherein the pain is moderate to severe pain.

4. The method of claim 2 , wherein the solid salt form of α-6-mPEG 6 -O-hydroxycodone is administered as necessary over a 24 hour period to manage moderate to severe pain.

5. A pharmaceutical composition comprising the solid salt form of α-6-mPEG 6 -O-hydroxycodone of claim 1 and at least one pharmaceutically acceptable excipient.

Assignments (14)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 9, 2023
From: INHERIS BIOPHARMA, INC.
To: NEKTAR THERAPEUTICS
Reel/Frame 062313/0501 →
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 053180/0009 →
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: INHERIS BIOPHARMA, INC.
Reel/Frame 052435/0062 →
CHANGE OF NAME Recorded Nov 15, 2019
From: INHERIS PHARMACEUTICALS, INC.
To: INHERIS BIOPHARMA, INC.
Reel/Frame 051038/0585 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 28, 2019
From: NEKTAR THERAPEUTICS
To: INHERIS PHARMACEUTICALS, INC.
Reel/Frame 050846/0461 →
SECURITY INTEREST Recorded Oct 28, 2019
From: INHERIS PHARMACEUTICALS, INC.
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 050846/0940 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 20, 2017
From: JOHNSON MATTHEY PHARMACEUTICAL MATERIALS, INC. D/B/A JOHNSON MATTHEY PHARMA SERVICES
To: NEKTAR THERAPEUTICS
Reel/Frame 042084/0318 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 12, 2017
From: MIRMEHRABI, MAHMOUD; PASCHALIDES, NICHOLAS
To: JOHNSON MATTHEY PHARMACEUTICAL MATERIALS, INC. D/B/A JOHNSON MATTHEY PHARMA SERVICES
Reel/Frame 041982/0433 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 30, 2017
From: AMRI SSCI, LLC
To: NEKTAR THERAPEUTICS
Reel/Frame 041801/0707 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 29, 2017
From: ANDRES, PATRICIA; DATAR, YOGESH
To: AMRI SSCI, LLC
Reel/Frame 041784/0136 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 29, 2017
From: GADIRAJU, RAMAKRISHNA; KOWALCZYK, BRUCE ANDREW; KUKLIS, GABRIEL CHRISTIAN
To: NEKTAR THERAPEUTICS
Reel/Frame 041784/0001 →
RELEASE OF SECURITY INTEREST RECORDED AT REEL 35767, FRAME 0695 Recorded Oct 14, 2015
From: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 036855/0686 →
GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS Recorded Oct 6, 2015
From: NEKTAR THERAPEUTICS
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 036796/0562 →
SECURITY INTEREST Recorded Jun 2, 2015
From: NEKTAR THERAPEUTICS
To: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 035767/0695 →