Method and system for controlling electrical conditions of tissue

1. A method for measuring a neural response to a stimulus, the method comprising:

providing a plurality of implantable electrodes including at least one nominal stimulus electrode, at least one nominal measurement electrode, at least one nominal feedback sense electrode and at least one nominal compensation electrode, the electrodes being implanted proximal to a neural tissue and being in electrical contact with the neural tissue;

applying an electrical stimulus to the neural tissue from the at least one stimulus electrode;

during an application of the stimulus, connecting a feedback signal from the at least one feedback sense electrode to an input of a feedback amplifier, and referencing the feedback amplifier to a desired electrical value;

during an application of the stimulus, connecting an output of the feedback amplifier to the at least one compensation electrode such that the feedback amplifier drives the neural tissue via the at least one compensation electrode in a feedback arrangement which seeks to drive the neural tissue to the desired electrical value; and

obtaining a measurement of a neural response from the at least one measurement electrode.

2. The method of claim 1 wherein the desired electrical value is electrical ground referenced to a patient ground electrode distal from the at least one feedback sense electrode.

3. The method of claim 1 wherein, during the entire period of stimulation, the feedback amplifier operates and is in connection with the at least one feedback sense electrode and at least one compensation electrode.

4. The method of claim 1 wherein the at least one feedback sense electrode and the at least one measurement electrode are located outside a dipole formed by the at least one stimulus electrode and the at least one compensating electrode.

5. An implantable device for controlling electrical conditions of tissue, the device comprising:

a plurality of implantable electrodes including at least one nominal feedback sense electrode, at least one nominal compensation electrode, at least one nominal stimulus electrode, and at least one nominal sense electrode; the electrodes being configured to be implanted proximal to the tissue to make electrical contact with the tissue;

a stimulus source for providing an electrical stimulus to be delivered from the at least one stimulus electrode to neural tissue;

measurement circuitry for amplifying a neural signal sensed at the at least one sense electrode; and

a feedback amplifier configured to be referenced to a desired electrical value and to take as an input a feedback signal from the feedback sense electrode during application of the stimulus, an output of the feedback amplifier being connected to the compensation electrode such that the feedback amplifier is configured to drive the neural tissue via the compensation electrode during application of the stimulus in a feedback arrangement which seeks to drive the feedback signal to the desired electrical value.

6. The device of claim 5 wherein the feedback amplifier is configured to operate in connection with the feedback sense electrode and compensation electrode during an entire period of the electrical stimulus.

7. The device of claim 5 wherein the desired electrical value is electrical ground referenced to a patient ground electrode distal from the feedback sense electrode.

8. The device of claim 5 wherein the feedback sense electrode and the measurement electrode are located outside a dipole formed by the stimulus electrode and the compensating electrode.