BPO wash gel composition
A topical dermatological/pharmaceutical composition is described that includes BPO wherein the composition is a wash composition with desirable tolerance, stability and foaming properties. The composition can include: a) benzoyl peroxide (BPO); b) at least one mild surfactant selected from anionic and/or non-ionic surfactant classes; c) zinc gluconate; d) dipotassium glycyrrhizate; and e) at least one gelling agent. The composition is preferably in the form of an aqueous gel or an aqueous-alcoholic gel. Also described, is the use of such a composition for the treatment of dermatological disorders, and in particular in the treatment of acne.
1. A topical wash composition comprising:
(a) benzoyl peroxide at a nonzero concentration of equal to or less than 5% w/w;
(b) at least one anionic and/or non-ionic surfactant selected from the group consisting of sodium lauroyl methyl isethionate, decyl glucoside, zinc coceth sulfate, sodium cocoyl isethionate, and C14-C16 α-olefinsulfonates;
(c) zinc gluconate; and
(d) dipotassium glycyrrhizate;
wherein at least 90% of the benzoyl peroxide in the composition remains in the composition after storage at 40° C. for one to two months.
2. The composition according to claim 1 , wherein the composition is a foaming composition.
3. The composition according to claim 1 , wherein the composition further comprises at least one gelling agent selected from the group consisting of gelling agents in the polyacrylamide family, “electrolyte-insensitive” carbomers, polysaccharides, cellulose derivatives, bentonite, magnesium aluminium silicates, neutralized polymeric sulfonic acid and mixtures thereof.
4. The composition according to claim 1 , wherein the composition comprises between 1% w/w and 5% w/w of benzoyl peroxide.
5. The composition according to claim 3 , wherein the gelling agent is a polysaccharide, a magnesium aluminium silicate or a mixture thereof.
6. The composition according to claim 5 , wherein the gelling agent is a xanthan gum, a magnesium aluminium silicate or a mixture thereof.
7. The composition according to claim 1 , wherein the composition further comprises a wetting agent.
8. The composition according to claim 7 , wherein the wetting agent is a poloxamer and/or a glycol.
9. The composition according to claim 7 , wherein the wetting agent is propylene glycol, Poloxamer 124, or a mixture thereof.
10. The composition according to claim 7 , wherein the wetting agent is at a concentration between 1% to 7% by weight with regards to the total composition weight.
11. The composition according to claim 1 , wherein benzoyl peroxide is in dispersed form.
12. The composition according to claim 1 , wherein the composition comprises between 2.5% and 3.5% of benzoyl peroxide expressed by weight of active ingredient relative to the total weight of the composition.
13. The composition according to claim 1 , wherein the concentration of zinc gluconate expressed by weight relative to the total weight of the composition is between 0.15% and 0.3%.
14. The composition according to claim 1 , wherein dipotassium glycyrrhizate is present at a concentration expressed by weight relative to the total weight of the composition between 0.15% and 0.3%.
15. A method of improving, or inhibiting a dermatological condition linked to acne treatment, the method comprising administering an effective amount of the composition according to claim 1 to an individual subject in need thereof.
16. A method of treating acne, comprising administering to a subject in need thereof an effective amount of the composition according to claim 1 .
17. The method as defined in claim 16 , wherein the acne is common acne.
18. The composition according to claim 13 , wherein the concentration of the zinc gluconate is between 0.2% and 0.3% by weight, relative to the total weight of the composition.
19. The composition according to claim 14 , wherein the concentration of the dipotassium glycyrrhizate is between 0.25% and 0.3% by weight, relative to the total weight of the composition.
20. The composition of claim 1 , wherein the anionic and/or non-ionic surfactant is present at a concentration of between 0.5 and 5% by weight, relative to the total weight of the composition.
21. The composition of claim 1 , wherein the dipotassium glycyrrhizate is present at a concentration of between 0.1 to 1% by weight, relative to the total weight of the composition.
22. The composition of claim 1 , wherein the zinc gluconate is present at a concentration of between 0.1 and 1% by weight, relative to the total weight of the composition.
23. The composition of claim 3 , wherein the gelling agent is present at a concentration of between 0.15 and 7% by weight, relative to the total weight of the composition.