USE OF AKKERMANSIA FOR TREATING METABOLIC DISORDERS
The present invention relates to Akkermansia muciniphila or fragments thereof for treating a metabolic disorder in a subject in need thereof. The present invention also relates to a composition, a pharmaceutical composition and a medicament comprising Akkermansia muciniphila or fragments thereof for treating a metabolic disorder. The present invention also relates to the use of Akkermansia muciniphila or fragments thereof for promoting weight loss in a subject in need thereof.
1 - 17 . (canceled)
18 . A method for treating a metabolic disorder in a subject in need thereof, comprising administering to the subject Akkermansia muciniphila or fragments thereof.
19 . The method according to claim 18 , wherein said metabolic disorder is obesity.
20 . The method according to claim 18 , wherein said metabolic disorder is selected from the group consisting of metabolic syndrome, insulin-deficiency or insulin-resistance related disorders, Diabetes Mellitus, glucose intolerance, abnormal lipid metabolism, atherosclerosis, hypertension, cardiac pathology, stroke, non-alcoholic fatty liver disease, hyperglycemia, hepatic steatosis, dyslipidemia, dysfunction of the immune system associated with overweight and obesity, cardiovascular diseases, high cholesterol, elevated triglycerides, asthma, sleep apnoea, osteoarthritis, neuro-degeneration, gallbladder disease, syndrome X, inflammatory and immune disorders, atherogenic dyslipidemia and cancer.
21 . The method according to claim 18 , wherein viable cells of Akkermansia muciniphila are administered to the subject in need thereof.
22 . The method according to claim 18 , wherein Akkermansia muciniphila or fragments thereof are orally administered.
23 . The method according to claim 18 , wherein an amount of Akkermansia muciniphila ranging from about 1·10 4 to about 1·10 12 cfu is administered to the subject.
24 . The method according to claim 18 , wherein Akkermansia muciniphila or fragments thereof are administered at least three times a week.
25 . The method according to claim 18 , wherein Akkermansia muciniphila or fragments thereof are co-administered with another probiotic strain and/or with one or more prebiotics.
26 . A method for increasing energy expenditure or for increasing satiety or for promoting weight loss in a subject, comprising administering Akkermansia muciniphila or fragments thereof to the subject.
27 . The method according to claim 26 , wherein said method does not impact the food intake of said subject.
28 . The method according to claim 26 , wherein viable cells of Akkermansia muciniphila are administered to the subject in need thereof.
29 . The method according to claim 26 , wherein Akkermansia muciniphila or fragments thereof are orally administered.
30 . The method according to claim 26 , wherein an amount of Akkermansia muciniphila ranging from about 1·10 4 to about 1·10 12 cfu is administered to the subject.
31 . The method according to claim 26 , wherein Akkermansia muciniphila or fragments thereof are administered at least three times a week.
32 . The method according to claim 26 , wherein Akkermansia muciniphila or fragments thereof are co-administered with another probiotic strain and/or with one or more prebiotics.
33 . A nutritional composition comprising Akkermansia muciniphila or fragments thereof.