Compositions and methods for enhancing brain function
Compositions and methods are provided that enhance cognition in a human to which the composition is orally administered. Remarkably, clinical studies have proven that contemplated compositions achieved the desired effects using a minimal number of active ingredients at or near threshold active dosages, wherein such compositions almost exclusively comprise huperzine A, vinpocetine or rhodiola, and acetyl-L-carnitine, and optionally further include alpha lipoic acid, rhodiola, and biotin.
1. A nutritional supplement composition for enhancing cognitive function, comprising:
huperzine A;
rhodiola; and
acetyl-L-carnitine;
wherein the composition is formulated for oral administration such that huperzine A, acetyl-L-carnitine, and rhodiola together account for at least 80 wt % of a dosage unit of the composition and the rhodiola is about 11.0% to about 22.0% by weight of the huperzine A, acetyl-L-carnitine and rhodiola, and the rhodiola and acetyl-L-carnitine are in a ratio of y:z respectively, wherein y is between about 1,600 and 2,400 for rhodiola and z is between about 8,000 and 12,000 for acetyl-L-carnitine.
2. The nutritional supplement composition of claim 1 , wherein the huperzine A, rhodiola, and acetyl-L-carnitine are in a ratio of x:y:z, respectively, wherein x is between about 0.8 and about 1.2, y is between about 1,600 and about 2,400 for rhodiola, and z is between about 8,000 and about 12,000.
3. The nutritional supplement composition of claim 2 , wherein x is between about 0.9 and about 1.1, y is between about 1,800 and about 2,200 for rhodiola, and z is between about 9,000 and about 11,000.
4. The nutritional supplement composition of claim 1 , wherein acetyl-L-carnitine is present in an amount from about 1250 mg to about 2000 mg.
5. The nutritional supplement composition of claim 1 , wherein rhodiola is present in an amount from about 250 mg to about 350 mg.
6. The nutritional supplement composition of claim 1 , wherein huperzine A is present in an amount from about 50 mcg to about 200 mcg.
7. The nutritional supplement composition of claim 1 , wherein the composition is formulated with an enteric coating.
8. The nutritional supplement composition of claim 1 , further comprising an inactive ingredient selected from the group consisting of a carrier, a binder, an excipient, a dye, and combinations thereof.
9. The nutritional supplement composition of claim 1 , wherein huperzine A, rhodiola, and acetyl-L-carnitine together account for at least 90 wt % of a dosage unit of the composition.
10. The nutritional supplement composition of claim 1 , wherein huperzine A, rhodiola, and acetyl-L-carnitine together account for at least 95 wt % of the dosage unit of the composition.
11. The nutritional supplement composition of claim 1 , wherein the dosage unit of the composition is equal or less than 1,200 mg.
12. A method of assisting enhancement of cognitive function in a person, comprising administering the nutritional supplement composition of claim 1 .
13. A nutritional supplement composition for enhancing cognitive function, comprising:
huperzine A;
rhodiola;
acetyl-L-carnitine;
biotin,
alpha lipoic acid; and
wherein the composition is formulated for oral administration such that the huperzine A, rhodiola, acetyl-L-carnitine, biotin, and alpha lipoic acid together account for at least 80 wt % of a dosage unit of the composition and the rhodiola is about 7.0 to 20.0 percent by weight of the huperzine A, rhodiola, acetyl-L-carnitine, biotin and alpha lipoic acid and the alpha lipoic acid is about 11.0 to 25.0 percent by weight of the huperzine A, rhodiola, acetyl-L-carnitine biotin and alpha lipoic acid, and the rhodiola and acetyl-L-carnitine are in a ratio of y:z respectively, wherein y is between about 1,600 and 2,400 for rhodiola and z is between about 8,000 and 12,000 for acetyl-L-carnitine.
14. The nutritional supplement composition of claim 13 , wherein acetyl-L-carnitine is present in an amount from about 1250 mg to about 2000 mg.
15. The nutritional supplement composition of claim 13 , wherein rhodiola is present in an amount from about 200 mg to about 400 mg.
16. The nutritional supplement composition of claim 13 , wherein huperzine A is present in an amount from about 50 mcg to about 200 mcg.
17. The nutritional supplement composition of claim 13 , further comprising alpha lipoic acid in an amount of about 300 mg to about 500 mg.
18. The nutritional supplement composition of claim 13 , further comprising biotin in an amount of about 400 mcg to about 600 mcg.
19. The nutritional supplement composition of claim 13 , wherein the dosage unit of the composition is equal or less than 1,200 mg.
20. A method of assisting enhancement of cognitive function in a person, comprising administering the nutritional supplement composition of claim 13 .