Technetium—and rhenium-bis(heteroaryl) complexes and methods of use thereof
View Patent ↗A method of imaging a region in a subject includes administering to the subject a complex of a metal chelated to a compound, and obtaining an image of the region in the subject.
1. A method of imaging a region in a subject, the method comprising: administering to the subject a complex comprising a metal chelated to a compound, and obtaining an image of the region in the subject, wherein the compound is represented as:
a pharmaceutically acceptable salt thereof;
f is an integer from 0 to 12; and
g is an integer from 0 to 12.
2. The method of claim 1 , wherein f is 2 to 10.
3. The method of claim 1 , wherein f is 4.
4. The method of claim 1 , wherein g is 2 to 10.
5. The method of claim 1 , wherein g is 4.
6. The method of claim 1 , wherein the compound is:
a pharmaceutically acceptable salt thereof.
7. The method of claim 6 , wherein f is 4.
8. The method of claim 1 , wherein the compound is:
a pharmaceutically acceptable salt thereof.
9. The method of claim 8 , wherein f is 4.
10. The method of claim 1 , wherein the compound is:
a pharmaceutically acceptable salt thereof.
11. The method of claim 10 , wherein g is 4.
12. The method of claim 1 , wherein the compound is:
a pharmaceutically acceptable salt thereof.
13. The method of claim 12 , wherein g is 4.
14. The method of claim 1 , wherein the metal is a radionuclide.
15. The method of claim 14 , wherein the radionuclide is technetium-99m, rhenium-188, or rhenium-186.
16. The method of claim 15 , wherein the radionuclide is technetium-99m.
17. The method of claim 15 , wherein the radionuclide is rhenium-188.
18. The method of claim 15 , wherein the radionuclide is rhenium-186.
19. The method of claim 1 , wherein the obtaining the image comprises using positron emission tomography (PET).
20. The method of claim 1 , wherein the obtaining the image comprises using single photon emission computed tomography (SPECT).
21. A complex comprising a metal chelated to a compound, wherein the compound is represented as:
a pharmaceutically acceptable salt thereof;
f is an integer from 0 to 12; and
g is an integer from 0 to 12.
22. The complex of claim 21 , wherein the metal is a radionuclide.
23. The complex of claim 22 , wherein the radionuclide is technetium-99m, rhenium-188, or rhenium-186.
24. The complex of claim 23 , wherein the radionuclide is technetium-99m.
25. The complex of claim 23 , wherein the radionuclide is rhenium-188.
26. The complex of claim 23 , wherein the radionuclide is rhenium-186.