Therapeutic methods and devices following myocardial infarction
View Patent ↗Described herein are methods of treating a patient to prevent or correct cardiac remodeling following myocardial infarction. In general these methods may include inserting or implanting a device in a heart chamber to support the affected region within 72 hours after myocardial infarction. The device may be a support device (e.g., a resilient frame) and/or a partitioning device.
1. An implant for treating a diseased condition of a heart, the implant comprising:
a flexible support frame comprising a plurality of expandable struts having a collapsed configuration and an expanded deployed configuration, wherein an unconstrained diameter of the plurality of struts is greater than a diameter of a heart chamber at a deployed location of the implant, so that the plurality of struts apply an outward biasing force to an interior surface of a ventricle wall in the expanded deployed configuration;
a membrane supported by the flexible support frame; and
a hub, wherein the expandable struts extend radially from the hub.
2. The implant of claim 1 , wherein the expandable struts are tipped with anchors configured to secure the support frame to the interior surface of the ventricle wall.
3. The implant of claim 1 , wherein the hub is configured to place the plurality of struts adjacent to the heart wall when the plurality of struts are in the expanded deployed configuration within the ventricle.
4. The implant of claim 1 , wherein a base portion of each of the plurality of struts proximate the hub is curved inwards with respect to a center line axis extending through the hub in the expanded deployed configuration.
5. The implant of claim 4 , wherein the base portion of each of the plurality of struts is configured to be biased against the ventricle wall to exert an outward force on the ventricle wall in the expanded deployed configuration.
6. The implant of claim 1 , wherein a tip portion of each of the plurality of struts is curved outwards with respect to a center line axis extending through the hub.
7. The implant of claim 1 , wherein a base portion of each of the plurality of struts proximate the hub is curved inwards and a tip portion of each of the plurality of struts is curved outwards with respect to a center line axis extending through the hub.
8. The implant of claim 1 , wherein the membrane is occlusive.
9. The implant of claim 1 , wherein the hub is non-traumatic.
10. A method for treating a diseased condition of a heart, the method comprising:
inserting an implant in a collapsed configuration into a ventricle of the heart, the implant comprising a flexible support frame comprising a plurality of radially expandable struts extending from a hub, and a membrane supported by the flexible support frame;
positioning the hub at the apex of the ventricle; and
expanding the support frame until the plurality of radially expandable struts and the membrane are positioned adjacent a ventricle wall; and
reducing a rate of remodeling of a diseased portion of the ventricle wall by at least partially partitioning a diseased portion from a healthy portion thereby reducing further damage to one or more of the diseased portion and the healthy portion of the ventricle wall.
11. The method of claim 10 , wherein the implant is inserted percutaneously into the ventricle.
12. The method of claim 10 , further comprising anchoring the struts into the ventricle wall.
13. The method of claim 10 , wherein the hub is configured to place the plurality of struts adjacent to the ventricle wall when the plurality of struts are expanded.
14. The method of claim 10 , further comprising covering a diseased portion of the ventricle wall with the support frame and membrane.
15. The method of claim 10 , wherein the struts are configured to be biased against the ventricle wall to exert an outward force on the ventricle wall after the support frame is expanded.