Apparatus and methods for feedback-based nerve modulation
A device according to some embodiments may include a housing configured for location external to a body of a subject. The device may also include at least one processor associated with the housing and configured to communicate with a circuit implanted in the subject within proximity to a tongue of the subject, wherein the circuit is in electrical communication with at least one electrode, receive a physiological signal from the subject via the circuit, and send a control signal to the implanted circuit in response to the physiological signal, wherein the control signal is predetermined to activate neuromuscular tissue within the tongue.
1. A hypertension therapy device for affecting blood pressure, the hypertension therapy device comprising:
a housing configured for location external to a body of a subject;
a first antenna configured to communicate with a second antenna associated with a circuit implanted in a blood vessel of the subject within proximity to at least one of a renal nerve, a baroreceptor, and a glossopharyngeal nerve, wherein the circuit is in electrical communication with at least one electrode;
a feedback circuit associated with the housing and configured to communicate with the first antenna;
at least one processor associated with the housing and further configured to:
communicate with the circuit through the first antenna;
receive a physiological signal from the subject;
send a control signal to the implanted circuit in response to the physiological signal, wherein the control signal is predetermined to modulate nerve tissue to affect blood pressure;
apply a sub-modulation control signal to the first antenna, the sub-modulation control signal inducing a secondary signal at the second antenna, the secondary signal in turn inducing a coupled signal at the first antenna;
receive, from the feedback circuit, the coupled signal generated by the first antenna; and
adjust the control signal based on the coupled signal received from the feedback circuit.
2. The hypertension therapy device of claim 1 , wherein the processor is configured to send the control signal within a response time between 1 millisecond and 10 minutes.
3. The hypertension therapy device of claim 1 , further comprising an antenna configured to transmit the control signal from the location outside of the subject's body to the second antenna associated with the implanted circuit.
4. The hypertension therapy device of claim 1 , wherein the physiological signal includes at least one aspect indicative of blood pressure of the subject.
5. The hypertension therapy device of claim 4 , wherein blood pressure is detected via a blood pressure sensor.
6. The hypertension therapy device of claim 1 , wherein the at least one processor is further configured to:
receive a signal, indicative of blood pressure, from a sensor remote from the implanted circuit.
7. The hypertension therapy device of claim 1 , wherein the at least one processor is further configured to determine a degree of blood pressure based on the physiological signal and vary a power level associated with the control signal based on the determined degree of the blood pressure.
8. The hypertension therapy device of claim 1 , wherein the at least one processor is further configured to determine a degree of blood pressure based on the physiological signal and vary a duration of the control signal based on the determined degree of the blood pressure.
9. The hypertension therapy device of claim 1 , wherein the at least one processor is further configured to receive a signal, indicative of blood pressure, from a sensor associated with the implanted circuit.
10. The hypertension therapy device of claim 1 , wherein the control signal is configured to perform at least one function chosen from the group consisting of stimulating the baroreceptor, down modulating the renal nerve, and stimulating the glossopharyngeal nerve.