CDK inhibitors
View Patent ↗Compounds of formulae I, II or III, and pharmaceutically acceptable salts thereof, are useful as CDK inhibitors.
1. A compound of formula:
or a pharmaceutically acceptable salt thereof, wherein:
each R 1 is independently hydrogen, aryl, alkyl, or haloalkyl, wherein each of said alkyl and haloalkyl groups optionally includes O or N heteroatoms in place of a carbon in the chain and two R 1 's on adjacent ring atoms can optionally form a 3-8-membered cycle; and
R x is halo, cyano, nitro, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclo, aryl, heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkyl.
2. The compound of claim 1 having formula:
3. The compound of claim 1 having formula:
4. The compound of claim 1 having formula:
5. The compound of claim 1 , wherein R x is C 1 -C 4 alkyl.
6. The compound of claim 2 , wherein R x is C 1 -C 4 alkyl.
7. The compound of claim 3 , wherein R x is C 1 -C 4 alkyl.
8. The compound of claim 4 , wherein R x is C 1 -C 4 alkyl.
9. The compound of claim 1 , wherein R x is halogen.
10. The compound of claim 2 , wherein R x is halogen.
11. The compound of claim 3 , wherein R x is halogen.
12. The compound of claim 4 , wherein R x is halogen.
13. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof.
14. A pharmaceutical composition comprising the compound of claim 2 , or a pharmaceutically acceptable salt thereof.
15. A pharmaceutical composition comprising the compound of claim 3 , or a pharmaceutically acceptable salt thereof.
16. A pharmaceutical composition comprising the compound of claim 4 , or a pharmaceutically acceptable salt thereof.