VETERINARY COMPOSITIONS
The present invention relates to veterinary compositions in a form of an orally deliverable tablet, and more particularly to a controlled-release composition that provides sufficiently long duration to permit once daily administration.
1 . A controlled-release veterinary composition in a form of an orally deliverable tablet prepared by direct compression comprising:
(a) at least one bioactive agent for veterinary use;
(b) a controlled release polymer selected from Hypromellose 2208 or Polyox WSR n-60; in an amount of about 5% to about 60% of the total weight of the tablet; and
(c) at least one disintegrant agent in an amount between about 10% to about 25% of the total weight of the tablet.
2 . (canceled)
3 . The composition of claim 1 wherein the bioactive agent is in an amount of about 2% to about 25% of the total weight of the tablet.
4 . The composition of claim 1 which may further comprise one or more enteric fillers or enteric polymers with a pH range of about 5.5-9.0.
5 . The bioactive agent of claim 1 selected from amoxicillin trihydrate, pregabalin, and N-methyl-1-{trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}methanesulfonamide.
6 . The bioactive agent of claim 5 which is N-methyl-1-{trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}methanesulfonamide.
7 . The composition of claim 1 wherein the polymer is Hypromellose 2208.
8 . The composition of claim 1 wherein the polymer is Polyox WSR n-60.
9 - 11 . (canceled)
12 . The composition of claim 1 wherein the polymer is in an amount of from about 20% to about 40%, by weight of the tablet.
13 . The composition of claim 1 wherein the disintegrant is selected from a group consisting of croscarmellose sodium, sodium carboxymethyl starch, cross linked povidone, and 2-hydroxypropyl ether (low substituted).
14 . The composition of claim 1 wherein the disintegrant is in an amount from about 10% to about 40% of the total weight of the tablet.
15 . (canceled)
16 . The composition of claim 14 wherein the disintegrant is in an amount from about 10% to about 25% of the total weight of the tablet.
17 . The composition of claim 1 further comprising veterinary acceptable excipients.
18 . The composition of claim 1 which is capable of prolonging gastric retention time up to 16 hours in canines for once-daily oral administration.
19 - 20 . (canceled)
21 . Use of the veterinary composition of claim 6 for the treatment of allergic reactions, allergic dermatitis, atopic dermatitis, eczema, pruritus and inflammatory diseases in dogs.
22 . (canceled)
23 . Use of the veterinary composition of claim 5 for the treatment of skin and soft-tissue infections such as wounds, abscesses, cellulitis, superficial (juvenile) or deep pyoderma, and periodontal infections in dogs wherein the bioactive agent is amoxicillin trihydrate.
24 . (canceled)