Filamentary devices for treatment of vascular defects
Devices and methods for treatment of a patient's vasculature with some embodiments configured for delivery with a microcatheter for treatment of the cerebral vasculature of a patient. Embodiments may include a self-expanding resilient permeable shell having a radially constrained elongated state configured for delivery within a catheter lumen, an expanded state with a globular and longitudinally shortened configuration relative to the radially constrained state, and a plurality of elongate filaments which are woven together, which define a cavity of the permeable shell Some embodiments may include at least about 40% composite filaments having a high strength material and a highly radiopaque material. In some embodiments, the total cross sectional area of the highly radiopaque material is between about 11% and about 30% of the total cross sectional area of the plurality of elongate elements.
1. A device for treatment of a patient's cerebral aneurysm, comprising:
a resilient self-expanding permeable shell including a radially constrained elongated state configured for delivery within a catheter lumen, an expanded state with a globular and longitudinally shortened configuration relative to the radially constrained state, and a plurality of elongate filaments which are woven together and define a cavity of the permeable shell, the permeable shell comprising at least some filaments consisting of nitinol and at least some composite filaments, the composite filaments comprising drawn filled tube wires comprising an external nitinol tube and a highly radiopaque material concentrically disposed within the external tube, and wherein the permeable shell has at least about 40% composite filaments relative to a total number of filaments, and wherein a total number of filaments is about 70 to about 300.
2. The device of claim 1 wherein the plurality of elongate filaments are secured relative to each other at a distal end of the permeable shell.
3. The device of claim 1 , wherein the plurality of elongate filaments are secured relative to each other at a proximal end of the permeable shell.
4. The device of claim 1 , wherein the drawn filled wires have a fill ratio of cross sectional area of between about 10% and about 50%.
5. The device of claim 1 , wherein the drawn filled tube wires have a fill ratio of cross sectional area of between about 20% and about 40%.
6. The device of claim 1 , wherein the drawn filled tube wires have a fill ratio of cross sectional area of between about 25% and about 35%.
7. The device of claim 1 , wherein the highly radiopaque material of the composite filaments comprises tantalum.
8. The device of claim 1 , wherein the highly radiopaque material of the composite filaments comprises platinum.
9. The device of claim 1 , wherein the highly radiopaque material of the composite filaments comprises gold.
10. The device of claim 1 , wherein a ratio of a number of the at least some filaments consisting of nitinol to the number of at least some composite filaments is selected from the group consisting of 1:1, 1:1.5, and 1.5:1.
11. The device of claim 1 , wherein each of the composite filaments has a diameter selected from the group consisting of 0.00075″, 0.001″, and 0.00125″.
12. A device for treatment of a patient's cerebral aneurysm, comprising:
a resilient self-expanding permeable shell including a radially constrained elongated state configured for delivery within a catheter lumen, an expanded state with a globular and longitudinally shortened configuration relative to the radially constrained state, and a plurality of elongate filaments which are woven together and define a cavity of the permeable shell, the plurality of filaments having a total cross sectional area, the permeable shell comprising at least some filaments consisting of nitinol and at least some composite filaments, the composite filaments comprising drawn filled tube wires comprising an external nitinol tube and a highly radiopaque material, and wherein the permeable shell has at least about 40% composite filaments relative to a total number of filaments, and wherein a total number of filaments is about 70 to about 300; and
wherein the total cross sectional area of the highly radiopaque material is between about 11% and about 30% of the total cross sectional area of the plurality of elongate elements.
13. The device of claim 12 , wherein the total cross sectional area of the highly radiopaque material is between about 15% and about 30% of the total cross sectional area of the plurality of elongate elements.
14. The device of claim 13 , wherein the total cross sectional area of the highly radiopaque material is between about 15% and about 22% of the total cross sectional area of the plurality of elongate elements.
15. The device of claim 13 , wherein the total cross sectional area of the highly radiopaque material is between about 19% and about 30% of the total cross sectional area of the plurality of elongate elements.
16. The device of claim 12 , wherein the total cross sectional area of the highly radiopaque material is between about 11 and about 18.5% of the total cross sectional area of the plurality of elongate elements.
17. The device of claim 12 , wherein the plurality of elongate filaments are secured relative to each other at a distal end of the permeable shell.
18. The device of claim 12 , wherein e plurality of elongate filaments are secured relative to each other at a proximal end of the permeable shell.
19. The device of claim 12 , wherein the drawn filled tube wires have a fill ratio of cross sectional area of between about 10% and about 50%.
20. The device of claim 12 , wherein the drawn filled tube wires have a fill ratio of cross sectional area of between about 20% and about 40%.
21. The device of claim 12 , wherein the drawn filled tube wires have a fill ratio of cross sectional area of between about 25% and about 35%.
22. The device of claim 12 , wherein the highly radiopaque material comprises tantalum.
23. The device of claim 12 , wherein the highly radiopaque material comprises platinum.
24. The device of claim 12 , wherein the highly radiopaque material comprises gold.
25. The device of claim 12 , wherein a ratio of a number of the at least some filaments consisting of nitinol to the number of at least some composite filaments is selected from the group consisting of 1:1, 1:1.5, and 1.5:1.
26. The device of claim 12 , wherein each of the composite filaments has a diameter selected horn the group consisting of 0.00075″, 0.001″, and 0.00125″.
27. A device for treatment of a patient's cerebral aneurysm, comprising:
a resilient self-expanding permeable shell including a radially constrained elongated state configured for delivery within a catheter lumen, an expanded state with a globular and longitudinally shortened configuration relative to the radially constrained state, and a plurality of elongate filaments which are woven together and define a cavity of the permeable shell, the permeable shell comprising at least some filaments consisting of nitinol and at least some composite filaments, the composite filaments comprising drawn filled tube wires comprising an external nitinol tube and a highly radiopaque material concentrically disposed within the external tube, and wherein a total number of filaments is about 70 to about 300, and wherein the permeable shell has either at least 40% composite filaments or has a total number of composite filaments between about 40 and 190.
28. The device of claim 27 , wherein the plurality of elongate filaments are secured relative to each other at a distal end of the permeable shell.
29. The device of claim 27 , wherein the plurality of elongate filaments are secured relative to each other at a proximal end of the permeable shell.
30. The device of claim 27 , wherein the highly radiopaque material of the composite filaments comprises platinum.
31. The device of claim 27 , wherein a ratio of a number of the at least some filaments consisting of nitinol to the number of at least some composite filaments is selected from the group consisting of 1:1, 1:1.5, and 1.5:1.
32. The device of claim 27 , wherein each of the composite filaments has a diameter selected from the group consisting of 0.00075″, 0.001″, and 0.00125″.
33. A device for treatment of a patient's cerebral aneurysm, comprising:
a resilient self-expanding permeable shell including a radially constrained elongated state configured for delivery within a catheter lumen, an expanded state with a globular and longitudinally shortened configuration relative to the radially constrained state, and a plurality of elongate filaments which are woven together and define a cavity of the permeable shell, the plurality of filaments having a total cross sectional area, the permeable shell comprising at least some filaments consisting of nitinol and at least some composite filaments, the composite filaments comprising drawn filled tube wires comprising an external nitinol tube and a highly radiopaque material, and wherein a total number of filaments is about 70 to about 300, and wherein the permeable shell has either at least 40% composite filaments or has a total number of composite filaments between about 40 and 190; and
wherein the total cross sectional area of the highly radiopaque material is between about 11% and about 30% of the total cross sectional area of the plurality of elongate elements.
34. The device of claim 33 , wherein the plurality of elongate filaments are secured relative to each other at a distal end of the permeable shell.
35. The device of claim 33 , wherein the plurality of elongate filaments are secured relative to each other at a proximal end of the permeable shell.
36. The device of claim 33 , wherein the highly radiopaque material of the composite filaments comprises platinum.
37. The device of claim 33 , wherein a ratio of a number of the at least some filaments consisting of nitinol to the number of at least some composite filaments is selected from the group consisting of 1:1, 1:1.5, and 1.5:1.
38. The device of claim 33 , wherein each of the composite filaments has a diameter selected from the group consisting of 0.00075″, 0.001″, and 0.00125″.