Hydrophilic coatings and methods for coating medical devices with hydrophilic coatings
View Patent ↗Medical device surfaces, for example a plastic catheter or metal guide wire, are disclosed with a lubricating coating made from Brasenia schreberi polysaccharide mucilage. The coated device surfaces may be prepared with a variety of techniques offering improved alternatives to conventional coatings.
1. A method of coating a medical device, comprising:
(a) applying a Brasenia schreberi polysaccharide mucilage to a substrate;
(b) curing the polysaccharide mucilage.
2. The method of claim 1 , wherein curing the polysaccharide includes applying ultraviolet light.
3. The method of claim 1 , wherein curing the polysaccharide includes adding a chemical curing agent selected from methanol, ethanol, and isopropyl alcohol.
4. A method of hydrophilic coating of normally hydrophobic surfaces, comprising:
(a) coating a hydrophobic surface with a Brasenia schreberi polysaccharide mucilage;
(b) dehydrating water from the coating by applying a water-miscible solvent;
(c) crosslinking and immobilizing the coating by applying a solution of catalyzed organic-soluble crosslinking agent.
5. The method of claim 4 , wherein the water-miscible solvent is selected from ethanol, methanol, propanol, acetone, methyl ethyl ketone, tetrahydrofuan, dimethyl sulfoxide, acetonitrile, dimethylformamide, acetic acid, and mixtures of the same.
6. The method of claims 4 , wherein the crosslinking agent is acrylic monomer.
7. The method of claim 1 , further comprising applying a second Brasenia schreberi polysaccharide mucilage coating.
8. The method of claim 5 , further comprising applying a second Brasenia schreberi polysaccharide mucilage coating.
9. A medical article prepared from the method of claim 1 .
10. The medical article of claim 9 , wherein the article is selected from a wire guide, a catheter, and a drainage stent.
11. A medical article prepared from the method of claim 5 .
12. The medical article of claim 11 , wherein the article is selected from a wire guide, a catheter, and a drainage stent.