Spot-on pesticide composition
View Patent ↗A spot-on pesticide composition for animals, specifically mammals, including dogs and cats, which composition comprises a combination of fipronil and etofenprox as the active components, in doses and proportions which are parasiticidally effective against a variety of insects and pests, and in a formulation which is convenient for local application to the mammal's skin, preferably localized over a small surface area.
1. A spot-on pesticidal composition consisting of about 1% to about 20% (w/w) fipronil, about 1% to about 20% (w/w) etofenprox, about 55% to about 80% (w/w) of an organic solvent selected from the group consisting of acetyltributyl citrate, fatty acid esters, diisobutyl adipate, acetone, acetonitrile, benzyl alcohol, butyl diglycol, dimethylacetamide, dimethylformamide, dipropylene glycol n-butyl ether, ethanol, isopropanol, methanol, ethylene glycol monoethyl ether, ethylene glycol monomethyl ether, diethylene glycol monoethyl ether, monomethylacetamide, dipropylene glycol monomethyl ether, liquid polyoxyethylene glycols, propylene glycol, 2-pyrrolidones, N-methylpyrrolidone, ethylene glycol, diethyl phthalate, and ethoxydiglycol, and optionally 0% to about 10% (w/w) of an antioxidant.
2. The spot-on pesticidal composition of claim 1 , wherein fipronil is present in an amount of about 5% to about 15% (w/w) fipronil and etofenprox is present in an amount of about 10% to about 18% (w/w).
3. The spot-on pesticidal composition of claim 1 , wherein fipronil is present in an amount of about 8% to about 10% (w/w) fipronil, etofenprox is present in an amount of about 12% to about 16% (w/w), and the organic solvent is present in an amount from about 65% to about 75% (w/w).
4. The spot-on pesticidal composition of claim 1 , wherein the organic solvent is diethylene glycol monoethyl ether.
5. The spot-on pesticidal composition of claim 1 , wherein the antioxidant is present in the composition at a concentration of about 1% to about 10% (w/w).
6. The spot-on pesticidal composition of claim 1 , wherein the antioxidant is present in the composition at a concentration of about 3% to about 6% (w/w).
7. The spot-on pesticidal composition of claim 1 , wherein the antioxidant is a vitamin E compound.
8. The spot-on pesticidal composition of claim 1 , wherein the antioxidant is selected from the group consisting of tocopherol acetate, tocopherol linoleate, tocopherol nicotinate, tocopherol succinate, ascorbyl tocopherol phosphate, dioleyl tocopherol methylsilanol, tocophersolan, tocopherol linoleate/oleate, and combinations thereof.
9. The spot-on pesticidal composition of claim 1 , wherein the antioxidant is tocopherol nicotinate.
10. A method of killing insect and pest pupae and adults on an animal, which method comprises: administering a localized cutaneous application between the shoulders or the animal, a spot-on composition consisting of about 1% to about 20% (w/w) fipronil, about 1% to about 20% (w/w) etofenprox, about 55% to about 80% (w/w) organic solvent selected from the group consisting of acetyltributyl citrate, fatty acid esters, diisobutyl adipate, acetone, acetonitrile, benzyl alcohol, butyl diglycol, dimethylacetamide, dimethyl form amide, dipropylene glycol n-butyl ether, ethanol, isopropanol, methanol, ethylene glycol monoethyl ether, ethylene glycol monomethyl ether, diethylene glycol monoethyl ether, monomethylacetamide, dipropylene glycol monomethyl ether, liquid polyoxyethylene glycols, propylene glycol, 2-pyrrolidones, N-methylpyrrolidone, ethylene glycol, diethyl phthalate, and ethoxydiglycol, and optionally 0% to about 10% (w/w) of an antioxidant, wherein the composition is administered in a volume sufficient to deliver a dosage of fipronil and etofenprox ranging from about 0.1 mg/kg to about 40 mg/kg of animal weight, and wherein at least 90% efficacy against insect and pest pupae is achieved.
11. The method of claim 10 , wherein the application is made as a one-time treatment.
12. The method of claim 10 , wherein the application is made every six weeks.
13. The method of claim 10 , wherein the application is made every five weeks.
14. The method of claim 10 , wherein the application is made every thirty days.
15. The method of claim 10 , wherein the application is made every four weeks.
16. The method of claim 10 , wherein the application is made every week.
17. The method of claim 10 , wherein the animal is a mammal.
18. The method of claim 17 , wherein the mammal is a dog or a cat.
19. The method of claim 10 , wherein the antioxidant is present in the composition at a concentration of about 1% to about 10% (w/w).
20. The method of claim 10 , wherein at least 95% efficacy is achieved.