Spot-on pesticide composition
View Patent ↗A spot-on pesticide composition for animals, specifically mammals, including dogs and cats, which composition comprises fipronil, etofenprox, and an insect growth regulator as the active components, in doses and proportions which are effective against a variety of insects and pests, and in a formulation which is convenient for local application to the animal's skin, preferably localized over a small surface area.
1. A spot-on pesticidal composition consisting of about 1% to about 20% (w/w) fipronil, about 1% to about 20% (w/w) etofenprox, about 1% to about 20% (w/w) insect growth regulator, about 55% to about 80% (w/w) organic solvent selected from the group consisting of acetyltributyl citrate, fatty acid esters, diisobutyl adipate, acetone, acetonitrile, benzyl alcohol, butyl diglycol, dimethylacetamide, dimethylformamide, dipropylene glycol n-butyl ether, ethanol, isopropanol, methanol, ethylene glycol monoethyl ether, ethylene glycol monomethyl ether, diethylene glycol monoethyl ether, monomethylacetamide, dipropylene glycol monomethyl ether, liquid polyoxyethylene glycols, propylene glycol, 2-pyrrolidones, N-methylpyrrolidone, ethylene glycol, diethyl phthalate, and ethoxydiglycol, and optionally 0% to about 10% (w/w) of an antioxidant.
2. The spot-on pesticidal composition of claim 1 , wherein the insect growth regulator is selected from the group consisting of bistrifluron, buprofezin, chlorfluazuron, cyromazine, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, penfluron, teflubenzuron, triflumuron, epofenonane, fenoxycarb, hydroprene, kinoprene, S-methoprene, pyriproxyfen, triprene, and combinations thereof.
3. The spot-on pesticidal composition of claim 1 , wherein fipronil is present in an amount of about 5% to about 15% (w/w), etofenprox is present in an amount of about 10% to about 18% (w/w), the insect growth regulator is present in an amount of about 2% to about 15% (w/w), and the organic solvent is present in an amount from about 55% to about 75% (w/w).
4. The spot-on pesticidal composition of claim 1 , wherein the insect growth regulator is S-methoprene.
5. The spot-on pesticidal composition of claim 1 , wherein fipronil is present in an amount of from about 8% to about 10% (w/w), etofenprox is present in an amount of from about 12% to about 16% (w/w), the insect growth regulator is present in an amount of from about 3% to about 5% (w/w), and the organic solvent is present in an amount of from about 70% to about 75% (w/w).
6. The spot-on pesticidal composition of claim 1 , wherein the insect growth regulator is pyriproxyfen.
7. The spot-on pesticidal composition of claim 1 , wherein the organic solvent is diethylene glycol monoethyl ether.
8. The spot-on pesticidal composition of claim 1 , wherein the antioxidant is present in the composition at a concentration of about 1% to about 10% (w/w).
9. The spot-on pesticidal composition of claim 1 , wherein the antioxidant is a vitamin E compound.
10. The spot-on pesticidal composition of claim 1 , wherein the antioxidant is selected from the group consisting of tocopherol acetate, tocopherol linoleate, tocopherol nicotinate, tocopherol succinate, ascorbyl tocopherol phosphate, dioleyl tocopherol methylsilanol, tocophersolan, tocopherol linoleate/oleate, and combinations thereof.
11. A method of killing insect and pest pupae and adults on an animal, which method comprises administering a localized cutaneous application between the shoulders of the animal, a spot-on composition consisting of about 1% to about 20% (w/w) fipronil, about 1% to about 20% (w/w) etofenprox, about 1% to about 20% (w/w) insect growth regulator, and about 55% to about 80% (w/w) organic solvent selected from the group consisting of acetyltributyl citrate, fatty acid esters, diisobutyl adipate, acetone, acetonitrile, benzyl alcohol, butyl diglycol, dimethylacetamide, dimethylformamide, dipropylene glycol n-butyl ether, ethanol, isopropanol, methanol, ethylene glycol monoethyl ether, ethylene glycol monomethyl ether, diethylene glycol monoethyl ether, monomethylacetamide, dipropylene glycol monomethyl ether, liquid polyoxyethylene glycols, propylene glycol, 2-pyrrolidones, N-methylpyrrolidone, ethylene glycol, diethyl phthalate, and ethoxydiglycol, and optionally 0% to about 10% (w/w) of an antioxidant, wherein the composition is administered in a volume sufficient to deliver a dosage of fipronil, etofenprox, and insect growth regulator ranging from about 0.1 mg/kg to about 40 mg/kg of animal weight, and wherein at least 90% efficacy against insect and pest pupae is achieved.
12. The method of claim 11 , wherein the application is made as a one-time treatment.
13. The method of claim 11 , wherein the application is made every six weeks.
14. The method of claim 11 , wherein the application is made every five weeks.
15. The method of claim 11 , wherein the application is made every thirty days.
16. The method of claim 11 , wherein the application is made every four weeks.
17. The method of claim 11 , wherein the application is made every week.
18. The method of claim 11 , wherein the animal is a mammal.
19. The method of claim 18 , wherein the mammal is a dog or a cat.
20. The method of claim 11 , wherein the antioxidant is present in the composition in an amount from about 1% to about 10% (w/w).
21. The method of claim 11 , wherein at least 95% efficacy is achieved.