IP Library › Granted Patent US 9,556,197

Granted Patent B2

US 9,556,197 · App. 14/465,910 · Granted Jan 31, 2017

Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors

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Patent No.: US 9,556,197
App. No.: 14/465,910
Granted: Jan 31, 2017
Kind: B2

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Abstract

The present disclosure describes furo- and thieno-pyridine carboxamide compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

Claims (418)

1. A compound of Formula (I):

or a pharmaceutically acceptable salt thereof, wherein:

X is S or O;

A 5 is C—R 5 ;

Cy A is a pyridinyl ring, wherein the pyridinyl ring is unsubstituted or substituted with 1, 2, or 3 R A ;

each R A is independently selected from R A1 , halogen, C 1-6 haloalkyl, CN, OR a1 , SR a1 , C(═O)R b1 , C(═O)NR c1 R d1 , C(═O)OR a1 , OC(═O)R b1 , OC(═O)NR c1 R d1 , NR c1 R d1 , NR c1 C(═O)R b1 , NR c1 C(═O)NR c1 R d1 , NR c1 C(═O)OR a1 , C(═NR e1 )NR c1 R d1 , NR c1 C(═NR e1 )NR c1 R d1 , S(═O)R b1 , S(═O)NR c1 R d1 , S(═O) 2 R b1 , NR c1 S(═O) 2 R b1 and S(═O) 2 R c1 R d1 ;

each R A1 is independently selected from C 1-6 alkyl, C 2-6 alkenyl and C 2-6 alkynyl, wherein each C 1-6 alkyl, C 2-6 alkenyl and C 2-6 alkynyl forming R A1 is unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents independently selected from halogen, CN, OR a1 , SR a1 , C(═O)R b1 , C(═O)NR c1 R d1 , C(═O)OR a1 , OC(═O)R b1 , OC(═O)NR c1 R d1 , NR c1 R d1 , NR c1 C(═O)R b1 , NR c1 C(═O)NR c1 R d1 , NR c1 C(═O)OR a1 , C(═NR e1 )NR c1 R d1 , NR c1 C(═NR e1 )NR c1 R d1 , S(═O)R b1 , S(═O)NR c1 R d1 , S(═O) 2 R b1 , NR c1 S(═O) 2 R b1 and S(═O) 2 NR c1 R d1 ;

Cy B is a 3-aminopiperidin-1-yl, wherein said piperidinyl is optionally substituted with 1, 2, 3, or 4 R B ;

each R B is independently selected from R B1 , R B2 , halogen, C 1-6 haloalkyl, CN, OR a2 , SR a2 , C(═O)R b2 , C(═O)NR c2 R d2 , C(═O)R a2 , OC(═O)R b2 , OC(═O)NR c2 R d2 , NR c2 R d2 , NR c2 C(═O)R b2 , NR c2 C(═O)NR c2 R d2 , NR c2 C(═O)OR a2 , C(═NR e2 )NR c2 R d2 , NR c2 C(═NR e2 )NR c2 R d2 , S(═O)NR c2 R d2 , S(═O) 2 R b2 , NR c2 S(═O) 2 R b2 and S(═O)NR c2 R d2 ,

each R B1 is independently selected from C 1-6 alkyl, C 2-6 alkenyl and C 2-6 alkynyl, wherein each of said C 1-6 alkyl, C 2-6 alkenyl and C 2-6 alkynyl of R B1 is unsubstituted or substituted with 1, 2, 3, 4 or 5 R B3 ;

each R B2 is independently selected from C 6-10 aryl, C 3-7 cycloalkyl, 5-10 membered heteroaryl and 4-10 membered heterocycloalkyl, wherein each of said C 6-10 aryl, C 3-7 cycloalkyl, 5-10 membered heteroaryl and 4-10 membered heterocycloalkyl forming R B2 is unsubstituted or substituted with 1, 2, 3, 4 or 5 R B4 ;

each R B3 is independently selected from R B2 , halogen, C 1-6 haloalkyl, CN, OR a2 , SR a2 , C(═O)R b2 , C(═O)NR c2 R d2 , C(═O)OR a2 , OC(═O)R b2 , OC(═O)NR c2 R d2 , NR c2 R d2 , NR c2 C(═O)R b2 , NR c2 C(═O)NR c2 R d2 , NR c2 C(═O)OR a2 , C(═NR e2 )NR c2 R d2 , NR c2 C(═NR e2 )NR c2 R d2 , S(═O)R b2 , S(═O)NR c2 R d2 , S(═O) 2 R b2 , NR c2 S(═O) 2 R b2 and S(═O) 2 NR c2 R d2 ;

each R B4 is independently selected from halogen, C 1-6 haloalkyl, CN, OR a2 , SR a2 , C(═O)R b2 , C(═O)NR c2 R d2 , C(═O)OR a2 , OC(═O)R b2 , OC(═O)NR c2 R d2 , NR c2 R d2 , NR c2 C(═O)R b2 , NR c2 C(═O)NR c2 R d2 , NR c2 C(═O)OR a2 , C(═NR e2 )NR c2 R d2 , NR c2 C(═NR e2 )NR c2 R d2 , S(═O)R b2 , S(═O)NR c2 R d2 , S(═O) 2 R b2 , NR c2 S(═O) 2 R b2 and S(═O) 2 NR c2 R d2 ;

R 2 is H, halogen or NH 2 ;

R 5 is H, halogen, R 5A , C 1-6 haloalkyl, CN, OR a3 , SR a3 , C(═O)R b3 , C(═O)NR c3 R d3 , C(═O)OR a3 , OC(═O)R b3 , OC(═O)NR c3 R d3 , NR c3 R d3 , NR c3 C(═O)R b3 , NR c3 C(═O)NR c3 R d3 , NR c3 C(═O)OR a3 , C(═NR e3 )NR c3 R d3 , NR c3 C(═NR e3 )NR c3 R d3 , S(═O)R b3 , S(═O)NR c3 R d3 , S(═O) 2 R b3 , NR c3 S(═O) 2 R b3 or S(═O) 2 NR c3 R d3 ;

R 5A is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl or phenyl, wherein each of said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl or phenyl forming R 5A is unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents independently selected from halogen, CN, OR a3 , SR a3 , C(═O)R b3 , C(═O)NR c3 R d3 , C(═O)OR a3 , OC(═O)R b3 , OC(═O)NR c3 R d3 , NR c3 R d3 , NR c3 C(═O)R b3 , NR c3 C(═O)NR c3 R d3 , NR c3 C(═O)OR a3 , C(═NR e3 )NR c3 R d3 , NR c3 C(═NR e3 )NR c3 R d3 , S(═O)R b3 , S(═O)NR c3 R d3 , S(═O) 2 R b3 , NR c3 S(═O) 2 R b3 and S(═O) 2 NR c3 R d3 ;

R 6 is H, halogen, R 6A , C 1-6 haloalkyl, CN, OR a4 , SR a4 , C(═O)R b4 , C(═O)NR c4 R d4 , C(═O)OR a4 , OC(═O)R b4 , OC(═O)NR c4 R d4 , NR c4 R d4 , NR c4 C(═O)R b4 , NR c4 C(═O)NR c4 R d4 , NR c4 C(═O)OR a4 , C(═NR e4 )NR c4 R d4 , NR c4 C(═NR e4 )NR c4 R d4 , S(═O)R b4 , S(═O)NR c4 R d4 , S(═O) 2 R b4 , NR c4 S(═O) 2 R b4 or S(═O) 2 NR c4 R d4 ;

R 6A is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 6-10 aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 3-7 cycloalkyl-C 1-4 alkyl-, C 6-10 aryl-C 1-4 alkyl-, 5-10 membered heteroaryl-C 1-4 alkyl- or 4-10 membered heterocycloalkyl-C 1-4 alkyl-, wherein each of said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 6-10 aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 3-7 cycloalkyl-C 1-4 alkyl-, C 6-10 aryl-C 1-4 alkyl-, 5-10 membered heteroaryl-C 1-4 alkyl- or 4-10 membered heterocycloalkyl-C 1-4 alkyl- forming R 6A is unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents independently selected from C 1-6 alkyl, halogen, C 1-6 haloalkyl, CN, OR a4 , SR a4 , C(═O)R b4 , C(═O)NR c4 R d4 , C(═O)OR a4 , OC(═O)R b4 , OC(═O)NR c4 R d4 , NR c4 R d4 , NR c4 C(═O)R b4 , NR c4 C(═O)NR c4 R d4 NR c4 C(═O)OR a4 , C(═NR e4 )NR c4 R d4 , NR c4 C(═NR e4 )NR c4 R d4 S(═O)R b4 , S(═O)NR c4 R d4 , S(═O) 2 R b4 , NR c4 S(═O) 2 R b4 and S(═O) 2 NR c4 R d4 ;

R 7 is H, halogen, R 7A , C 1-6 haloalkyl, CN, OR a5 , SR a5 , C(═O)R b5 , C(═O)NR c5 R d5 , C(═O)OR a5 , OC(═O)R b5 , OC(═O)NR c5 R d5 , NR c5 R d5 , NR c5 C(═O)R b5 , NR c5 C(═O)NR c5 R d5 , NR c5 C(═O)OR a5 , C(═NR e5 )NR c5 R d5 , NR c5 C(═NR e5 )NR c5 R d5 , S(═O)R b5 , S(═O)NR c5 R d5 , S(═O) 2 R b5 , NR c5 S(═O) 2 R b5 or S(═O) 2 NR c5 R d5 ;

R 7A is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 6-10 aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 3-7 cycloalkyl-C 1-4 alkyl-, C 6-10 aryl-C 1-4 alkyl-, 5-10 membered heteroaryl-C 1-4 alkyl- or 4-10 membered heterocycloalkyl-C 1-4 alkyl-, wherein each of said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 6-10 aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 3-7 cycloalkyl-C 1-4 alkyl-, C 6-10 aryl-C 1-4 alkyl-, 5-10 membered heteroaryl-C 1-4 alkyl- or 4-10 membered heterocycloalkyl-C 1-4 alkyl- forming R 7A is unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents independently selected from C 1-6 alkyl, halogen, C 1-6 haloalkyl, CN, OR a5 , SR a5 , C(═O)R b5 , (═O)NR c5 R d5 , C(═O)OR a5 , OC(═O)R b5 , OC(═O)NR c5 R d5 , NR c5 R d5 , NR c5 C(═O)R b5 , NR c5 C(═O)NR c5 R d5 , NR c5 C(═O)OR a5 , C(═NR e5 )NR c5 R d5 , NR c5 C(═NR e5 )NR c5 R d5 , S(═O)R b5 , S(═O)NR c5 R d5 , S(═O) 2 R b5 , NR c5 S(═O) 2 R b5 and S(═O) 2 NR c5 R d5 ;

R a1 , R b1 , R c1 and R d1 are each independently selected from H, C 1-6 alkyl, C 2-6 alkenyl and C 2-6 alkynyl;

R a2 , R b2 , R c2 and R d2 are each independently selected from H, C 1-6 alkyl, C 2-6 alkenyl and C 2-6 alkynyl;

R a3 , R b3 , R c3 and R d3 are each independently selected from H, C 1-6 alkyl, C 2-6 alkenyl and C 2-6 alkynyl;

R a4 , R b4 , R c4 and R d4 are each independently selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-10 aryl, C 3-7 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 aryl-C 1-3 alkyl, 5-10 membered heteroaryl-C 1-3 alkyl, C 3-7 cycloalkyl-C 1-3 alkyl and 4-10 membered heterocycloalkyl-C 1-3 alkyl, wherein said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-10 aryl, C 3-7 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 aryl-C 1-3 alkyl, 5-10 membered heteroaryl-C 1-3 alkyl, C 3-7 cycloalkyl-C 1-3 alkyl and 4-10 membered heterocycloalkyl-C 1-3 alkyl forming R a4 , R b4 , R c4 and R d4 are each unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents independently selected from C 1-6 alkyl, halo, CN, OR a6 , SR a6 , C(═O)R b6 , C(═O)NR c6 R d6 , C(═O)OR a6 , OC(═O)R b6 , OC(═O)NR c6 R d6 , NR c6 R d6 , NR c6 C(═O)R b6 , NR c6 C(═O)NR c6 R d6 , NR c6 C(═O)OR a6 , C(═NR e6 )NR c6 R d6 , NR c6 C(═NR e6 )NR c6 R d6 , S(═O)R b6 , S(═O)NR c6 R d6 , S(═O) 2 R b6 , NR c6 S(═O) 2 R b6 and S(═O) 2 NR c6 R d6 ;

or R c4 and R d4 attached to the same N atom, together with the N atom to which they are both attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group or 5-membered heteroaryl group, each optionally substituted with 1, 2 or 3 substituents independently selected from C 1-6 alkyl, halo, CN, OR a6 , SR a6 , C(═O)R b6 , C(═O)NR c6 R d6 , C(═O)OR a6 , OC(═O)R b6 , OC(═O)NR c6 R d6 , NR c6 R d6 , NR c6 C(═O)R b6 , NR c6 C(═O)NR c6 R d6 , NR c6 C(═O)OR a6 , C(═NR e6 )NR c6 R d6 , NR c6 C(═NR e6 )NR c6 R d6 , S(═O)R b6 , S(═O)NR c6 R d6 , S(═O) 2 R b6 , NR c6 S(═O) 2 R b6 and S(═O) 2 NR c6 R d6 ;

R a5 , R b5 , R c5 and R d5 are each independently selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-10 aryl, C 3-7 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 aryl-C 1-3 alkyl, 5-10 membered heteroaryl-C 1-3 alkyl, C 3-7 cycloalkyl-C 1-3 alkyl and 4-10 membered heterocycloalkyl-C 1-3 alkyl, wherein said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-10 aryl, C 3-7 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 aryl-C 1-3 alkyl, 5-10 membered heteroaryl-C 1-3 alkyl, C 3-7 cycloalkyl-C 1-3 alkyl and 4-10 membered heterocycloalkyl-C 1-3 alkyl forming R a5 , R b5 , R c5 and R d5 are each unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents independently selected from C 1-6 alkyl, halo, CN, OR a6 , SR a6 , C(═O)R b6 , C(═O)NR c6 R d6 , C(═O)OR a6 , OC(═O)R b6 , OC(═O)NR c6 R d6 , NR c6 R d6 , NR c6 C(═O)R b6 , NR c6 C(═O)NR c6 R d6 , NR c6 C(═O)OR a6 , C(═NR e6 )NR c6 R d6 , NR c6 C(═NR e6 )NR c6 R d6 , S(═O)R b6 , S(═O)NR c6 R d6 , S(═O) 2 R b6 , NR c6 S(═O) 2 R b6 and S(═O) 2 NR c6 R d6 ;

or R c5 and R d5 attached to the same N atom, together with the N atom to which they are both attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group or 5-membered heteroaryl group, each optionally substituted with 1, 2 or 3 substituents independently selected from C 1-6 alkyl, halo, CN, OR a6 , SR a6 , C(═O)R b6 , C(═O)NR c6 R d6 , C(═O)OR a6 , OC(═O)R b6 , OC(═O)NR c6 R d6 , NR c6 R d6 , NR c6 C(═O)R b6 , NR c6 C(═O)NR c6 R d6 , NR c6 C(═O)OR a6 , C(═NR e6 )NR c6 R d6 , NR c6 C(═NR e6 )NR c6 R d6 , S(═O)R b6 , S(═O)NR c6 R d6 , S(═O) 2 R b6 , NR c6 S(═O) 2 R b6 and S(═O) 2 NR c6 R d6 ;

R a6 , R b6 , R c6 and R d6 are each independently selected from H, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-10 aryl, 5-10 membered heteroaryl, C 3-7 cycloalkyl and 4-10 membered heterocycloalkyl, wherein said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-10 aryl, 5-10 membered heteroaryl, C 3-7 cycloalkyl and 4-10 membered heterocycloalkyl forming R a6 , R b6 , R c6 and R d6 are each optionally substituted with 1, 2 or 3 substituents independently selected from OH, CN, amino, NH(C 1-6 alkyl), N(C 1-6 alkyl) 2 , halo, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl and C 1-6 haloalkoxy;

or R c6 and R d6 attached to the same N atom, together with the N atom to which they are both attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group or 5-membered heteroaryl group, each optionally substituted with 1, 2 or 3 substituents independently selected from OH, CN, amino, NH(C 1-6 alkyl), N(C 1-6 alkyl) 2 , halo, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl and C 1-6 haloalkoxy; and

R e1 , R e2 , R e3 , R e4 , R e5 and R e6 are each, independently, H, C 1-4 alkyl, CN or NO 2 .

2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein X is O.

3. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein X is S.

4. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each R A is independently selected from C 1-6 alkyl, C 2-6 alkenyl C 2-6 alkynyl, halogen, C 1-6 haloalkyl, CN, OR a1 , SR a1 , C(═O)R b1 , C(═O)NR c1 R d1 , C(═O)OR a1 , OC(═O)R b1 , OC(═O)NR c1 R d1 , NR c1 R d1 , NR C1 C(═O)R b1 , NR c1 C(═O)NR c1 R d1 , NR c1 C(═O)OR a1 , C(═NR e1 )NR c1 R d1 , NR c1 C(═NR e1 )NR c1 R d1 , S(═O)R b1 , S(═O)NR c1 R d1 , S(═O) 2 R b1 , NR c1 S(═O) 2 R b1 and S(═O) 2 NR c1 R d1 .

5. The compound of claim 4 , or a pharmaceutically acceptable salt thereof, wherein each R A is C 1-6 alkyl.

6. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Cy A is pyridin-3-yl or 5-methylpyridin-3-yl.

7. The compound of claim 1 , wherein each R B is independently selected from halogen, C 1-6 alkyl, C 1-6 haloalkyl, C 3-7 cycloalkyl, CN, OR a2 and NR c2 R d2 .

8. The compound of claim 7 , or a pharmaceutically acceptable salt thereof, wherein each R B is independently selected from methyl, ethyl, cyclopropyl, CF 3 , OH and NH 2 .

9. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Cy B is a piperidinyl group of the following Formula (B-1):

wherein:

R c2 is H;

R d2 is H;

a is 1;

b is 1; and

wherein the piperidinyl group of Formula (B-1) is further substituted by 0, 1, 2, or 3 R B , wherein R B is independently, at each occurrence, selected from F, Cl, methyl, ethyl, cyclopropyl, CF 3 , CN, OH, and methoxy.

10. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Cy B is a group of Formula Cy B -1:

wherein:

W is N;

Y is H or OH; and

Z is H, C 1-6 alkyl, C 1-3 haloalkyl, or C 3-7 cycloalkyl.

11. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Cy B is a group of Formula Cy B -2:

wherein:

W is N;

Y is H or OH; and

Z is H, C 1-6 alkyl, C 1-3 haloalkyl, or C 3-7 cycloalkyl.

12. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Cy B is a group selected from groups of the following Formulae (B-2) to (B-8):

13. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Cy B is a group selected from groups of the following Formulae (B-2a) to (B-8a):

14. The compound of claim 13 , or a pharmaceutically acceptable salt thereof, wherein Cy B is a group of Formula (B-8a):

15. The compound of claim 13 , or a pharmaceutically acceptable salt thereof, wherein Cy B is a group of Formula (B-7a):

16. The compound of claim 13 , or a pharmaceutically acceptable salt thereof, wherein Cy B is a group of Formula (B-5a):

17. The compound of claim 13 , or a pharmaceutically acceptable salt thereof, wherein Cy B is a group of Formula (B-4a):

18. The compound of claim 13 , or a pharmaceutically acceptable salt thereof, wherein Cy B is a group of Formula (B-3a):

19. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Cy B is a group selected from groups of the following Formulae (B-101) to (B-107) and (B-115) to (B-121):

20. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the group:

is selected from groups of Formulae (Cy-1) to (Cy-12):

21. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 is NH 2 .

22. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 5 is H, halogen, R 5A , CN or OR a3 .

23. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 5 is R 5A and R 5A is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 3-7 cycloalkyl or phenyl, wherein each of said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl or phenyl forming R 5A is unsubstituted or substituted with 1, 2 or 3 substituents independently selected from halogen, CN and OR a3 .

24. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 5 is H, halogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 3-7 cycloalkyl, phenyl, R 5A , CN, OR a3 , SR a3 , C(═O)R b3 , C(═O)NR c3 R d3 , C(═O)OR a3 , OC(═O)R b3 , OC(═O)NR c3 R d3 , NR c3 R d3 , NR c3 C(═O)R b3 , NR c3 C(═O)NR c3 R d3 , NR c3 C(═O)OR a3 , C(═NR e3 )NR c3 R d3 , NR c3 C(═NR e3 )NR c3 R d3 , S(═O)R b3 , S(═O)NR c3 R d3 , S(═O) 2 R b3 , NR c3 S(═O) 2 R b3 or S(═O) 2 NR c3 R d3 .

25. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 5 is H, halogen or C 1-6 alkyl.

26. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 5 is H.

27. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 6 is H, halogen, R 6A , C 1-6 haloalkyl, CN or OR a4 .

28. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 6 is H, halogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 6-10 aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 3-7 cycloalkyl-C 1-4 alkyl-, C 6-10 aryl-C 1-4 alkyl-, 5-10 membered heteroaryl-C 1-4 alkyl-, 4-10 membered heterocycloalkyl-C 1-4 alkyl-, C 1-6 haloalkyl, CN, OR a4 , SR a4 , C(═O)R b4 , C(═O)NR c4 R d4 , C(═O)OR a4 , OC(═O)R b4 , OC(═O)NR c4 R d4 , NR c4 R d4 , NR c4 C(═O)R b4 , NR c4 C(═O)NR c4 R d4 , NR c4 C(═O)OR a4 , C(═NR e4 )NR c4 R d4 , NR c4 C(═NR e4 )NR c4 R d4 , S(═O)R b4 , S(═O)NR c4 R d4 , S(═O) 2 R b4 , NR c4 S(═O) 2 R b4 or S(═O) 2 NR c4 R d4 .

29. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 6 is H, halogen, C 1-6 alkyl, OH, OC 1-6 alkyl, OC 3-7 cycloalkyl, C 1-6 haloalkyl, C 6-10 aryl, 5-6-membered heteroaryl or 4-7 membered heterocycloalkyl.

30. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 6 is H, F, Cl, Br, methyl, ethyl, propyl, isopropyl, CF 3 , OH, OMe, OEt, On-Pr, Oi-Pr, Ocyclopropyl, phenyl, 2,6-difluorophenyl, 3,5-dimethylisoxazol-4-yl, 1,3-thiazol-2-yl, 1-methylazetidin-3-yl, 1-isopropylazetidin-3-yl, methoxymethyl or tetrahydro-2H-pyran-4-yl.

31. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 6 is H.

32. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 6 is R 6A and R 6A is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, phenyl, 5-6 membered heteroaryl or 4-7 membered heterocycloalkyl, wherein each of said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, phenyl, 5-6 membered heteroaryl or 4-7 membered heterocycloalkyl forming R 6A is unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents independently selected from C 1-6 alkyl, halogen, CN and OR a4 .

33. The compound of claim 32 , or a pharmaceutically acceptable salt thereof, wherein R 6 is R 6A and R 6A is unsubstituted phenyl or phenyl substituted with 1, 2, 3, 4 or 5 substituents independently selected from C 1-6 alkyl, halogen, CN and OR a4 .

34. The compound of claim 32 , or a pharmaceutically acceptable salt thereof, wherein R 6 is R 6A and R 6A is unsubstituted phenyl or phenyl 2,6-disubstituted with substituents independently selected from C 1-6 alkyl, halogen, CN and OR a4 .

35. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 7 is H, halogen, R 7A , C 1-6 haloalkyl, CN, OR a5 , SR a5 , C(═O)R b5 , C(═O)NR c5 R d5 , C(═O)OR a5 , OC(═O)R b5 , OC(═O)NR c5 R d5 , NR c5 R d5 , NR c5 C(═O)R b5 , NR c5 C(═O)NR c5 R d5 , NR c5 C(═O)OR a5 , C(═NR e5 )NR c5 R d5 , NR c5 C(═NR e5 )NR c5 R d5 , S(═O)R b5 , S(═O)NR c5 R d5 , S(═O) 2 R b5 , NR c5 S(═O) 2 R b5 or S(═O) 2 NR c5 R d5 .

36. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 7 is H, halogen, R 7A , C 1-6 haloalkyl, CN or OR a5 .

37. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 7 is R 7A and R 7A is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl or phenyl, wherein each C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl and phenyl forming R 7A is unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents independently selected from C 1-6 alkyl, halogen, C 1-6 haloalkyl, CN, OR a5 , SR a5 , C(═O)R b5 , C(═O)NR c5 R d5 , C(═O)OR a5 , OC(═O)R b5 , OC(═O)NR c5 R d5 , NR c5 R d5 , NR c5 C(═O)R b5 , NR c5 C(═O)NR c5 R d5 , NR c5 C(═O)OR a5 , C(═NR e5 )NR c5 R d5 , NR c5 C(═NR e5 )NR c5 R d5 , S(═O)R b5 , S(═O) 2 NR c5 R d5 , S(═O) 2 R b5 , NR c5 S(═O) 2 R b5 and S(═O) 2 NR c5 R d5 .

38. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 7 is H, halogen, C 1-6 alkyl, C 1-6 haloalkyl, or O(C 1-6 alkyl).

39. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 7 is H, Cl, methyl, ethyl, CF 3 , OMe, OEt, On-Pr or Oi-Pr.

40. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 7 is H.

41. The compound of claim 1 of Formula (I-A):

or a pharmaceutically acceptable salt thereof, wherein:

X is S or O;

Cy A is a pyridinyl ring, wherein the pyridinyl ring is unsubstituted or substituted with 1, 2, or 3 R A ;

each R A is independently selected from halogen, CN, OH, C 1-6 alkyl, C 1-6 haloalkyl and C 1-6 alkoxy;

Cy B is a 3-aminopiperidin-1-yl, wherein the piperidinyl ring is optionally substituted with 1, 2, 3, or 4 R B ;

each R B is independently selected from halogen, C 1-6 alkyl, C 1-6 haloalkyl, C 3-7 cycloalkyl, CN, OR a2 , SR a2 , C(═O)R b2 , C(═O)NR c2 R d2 , C(═O)OR a2 , OC(═O)R b2 , OC(═O)NR c2 R d2 , NR c2 R d2 , NR c2 C(═O)R b2 , NR c2 C(═O)NR c2 R d2 , NR c2 C(═O)OR a2 , C(═NR e2 )NR c2 R d2 , NR c2 C(═NR e2 )NR c2 R d2 , S(═O)R b2 , S(═O)NR c2 R d2 , S(═O) 2 R b2 , NR c2 S(═O) 2 R b2 and S(═O) 2 NR c2 R d2 ;

R 2 is H, halogen or NH 2 ;

R 5A is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl or phenyl wherein each of said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl or phenyl forming R 5A is unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents independently selected from halogen, CN, OR a3 , SR a3 , C(═O)R b3 , C(═O)NR c3 R d3 , C(═O)OR a3 , OC(═O)R b3 , OC(═O)NR c3 R d3 , NR c3 R d3 , NR c3 C(═O)R b3 , NR c3 C(═O)NR c3 R d3 , N R3 C(═O)OR a3 , C(═NR e3 )NR c3 R d3 , NR c3 C(═NR e3 )NR c3 R d3 , S(═O)R b3 , S(═O)NR c3 R d3 , S(═O) 2 R b3 , NR c3 S(═O) 2 R b3 and S(═O) 2 NR c3 R d3 ;

R 6 is H, halogen, R 6A , C 1-6 haloalkyl, CN, OR a4 , SR a4 , C(═O)R b4 , C(═O)NR c4 R d4 , C(═O)OR a4 , OC(═O)R b4 , OC(═O)NR c4 R d4 , NR c4 R d4 NR c4 C(═O)R b4 , NR c4 C(═O)NR c4 R d4 , NR c4 C(═O)OR a4 , C(═NR e4 )NR c4 R d4 , NR c4 C(═NR e4 )NR c4 R d4 , S(═O)R b4 , S(═O)NR c4 R d4 , S(═O) 2 R b4 , NR c4 S(═O) 2 R b4 or S(═O) 2 NR c4 R d4 ;

R 6A is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 6-10 aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 3-7 cycloalkyl-C 1-4 alkyl-, C 6-10 aryl-C 1-4 alkyl-, 5-10 membered heteroaryl-C 1-4 alkyl- or 4-10 membered heterocycloalkyl-C 1-4 alkyl- wherein each of said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C3-7 cycloalkyl, C 6-10 aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 3-7 cycloalkyl-C 1-4 alkyl-, C 6-10 aryl-C 1-4 alkyl-, 5-10 membered heteroaryl-C 1-4 alkyl- or 4-10 membered heterocycloalkyl-C 1-4 alkyl- forming R 6A is unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents independently selected from C 1-6 alkyl, halogen, C 1-6 haloalkyl, CN, OR a4 , SR a4 , C(═O)R b4 , C(═O)NR c4 R d4 , C(═O)OR a4 , OC(═O)R b4 , OC(═O)NR c4 R d4 , NR c4 R d4 , NR c4 C(═O)NR b4 , NR c4 C(═O)NR c4 R d4 , NR c4 C(═O)OR a4 , C(═NR e4 )NR c4 R d4 , NR c4 C(═NR e4 )NR c4 R d4 , S(═O)R b4 , S(═O)NR c4 R d4 , S(═O) 2 R b4 , NR c4 S(═O) 2 R b4 and S(═O) 2 NR c4 R d4 ;

R 7 is H, halogen, R 7A , C 1-6 haloalkyl, CN, OR a5 , SR a5 , C(═O)R b5 , C(═O)NR c5 R d5 , C(═O)OR a5 , OC(═O)R b5 , OC(═O)NR c5 R d5 , NR c5 R d5 , NR c5 C(═O)R b5 , NR c5 C(═O)NR c5 R d5 , NR c5 C(═O)OR a5 , C(═NR e5 )NR c5 R d5 , NR c5 C(═NR e5 )N c5 R d5 , S(═O)R b5 , S(═O)NR c5 R d5 , S(═O) 2 R b5 , NR c5 S(═O) 2 R b5 or S(═O) 2 NR c5 R d5 ;

R 7A is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 6-10 aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 3-7 cycloalkyl-C 1-4 alkyl-, C 6-10 aryl-C 1-4 alkyl-, 5-10 membered heteroaryl-C 1-4 alkyl- or 4-10 membered heterocycloalkyl-C 1-4 alkyl-, wherein each of said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 6-10 aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 3-7 cycloalkyl-C 1-4 alkyl-, C 6-10 aryl-C 1-4 alkyl-, 5-10 membered heteroaryl-C 1-4 alkyl- and 4-10 membered heterocycloalkyl-C 1-4 alkyl- forming R 7A is unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents independently selected from C 1-6 alkyl, halogen, C 1-6 haloalkyl, CN, OR a5 , SR a5 , C(═O)R b5 , C(═O)NR c5 R d5 , C(═O)OR a5 , OC(═O)R b5 , OC(═O)NR c5 R d5 , NR c5 R d5 , NR c5 C(═O)R b5 , NR c5 C(═O)NR c5 R d5 , NR c5 C(═O)OR a5 , C(═NR e5 )NR c5 R d5 , NR c5 C(═NR e5 )NR c5 R d5 , S(═O)R b5 , S(═O)NR c5 R d5 , S(═O) 2 R b5 , NR c5 S(═O) 2 R b5 and S(═O) 2 NR c5 R d5 ;

R a1 , R b1 , R c1 and R d1 are each independently selected from H, C 1-6 alkyl, C 2-6 alkenyl and C 2-6 alkynyl;

R a2 , R b2 , R c2 and R d2 are each independently selected from H, C 1-6 alkyl, C 2-6 alkenyl and C 2-6 alkynyl;

R a3 , R b3 , R c3 and R d3 are each independently selected from H, C 1-6 alkyl, C 2-6 alkenyl and C 2-6 alkynyl;

R a4 , R b4 , R c4 and R d4 are each independently selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-10 aryl, C 3-7 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 aryl-C 1-3 alkyl, 5-10 membered heteroaryl-C 1-3 alkyl, C 3-7 cycloalkyl-C 1-3 alkyl and 4-10 membered heterocycloalkyl-C 1-3 alkyl, wherein said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-10 aryl, C 3-7 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 aryl-C 1-3 alkyl, 5-10 membered heteroaryl-C 1-3 alkyl, C 3-7 cycloalkyl-C 1-3 alkyl and 4-10 membered heterocycloalkyl-C 1-3 alkyl forming R a4 , R b4 , R c4 and R d4 are each unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents independently selected from C 1-6 alkyl, halo, CN, OR a6 , SR a6 , (═O)R b6 , C(═O)NR c6 R d6 , C(═O)OR a6 , OC(═O)R b6 , OC(═O)NR c6 R d6 , NR c6 R d6 , NR c6 C(═O)R b6 , NR c6 C(═O)NR c6 R d6 , NR c6 C(═O)OR a6 , C(═NR e6 )NR c6 R d6 , NR c6 C(═NR e6 )NR c6 R d6 , S(═O)R b6 , S(═O)NR c6 R d6 , S(═O) 2 R b6 , NR c6 S(═O) 2 R b6 and S(═O) 2 NR c6 R d6 ;

R a6 , R b6 , R c6 and R d6 are each independently selected from H, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, C 6-10 aryl, 5-10 membered heteroaryl, C 3-7 cycloalkyl and 4-10 membered heterocycloalkyl, wherein said C 1-6 alkyl, C 2-6 alkenyl, C2-6 alkynyl C 6-10 aryl, 5-10 membered heteroaryl, C 3-7 cycloalkyl and 4-10 membered heterocycloalkyl forming R a6 , R b6 , R c6 and R d6 are each optionally substituted with 1, 2 or 3 substituents independently selected from OH, CN, amino, NH(C 1-6 alkyl), N(C 1-6 alkyl) 2 , halo, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl and C 1-6 haloalkoxy;

R e1 , R e2 , R e3 , R e4 , R e5 and R e6 are each, independently, H, C 1-4 alkyl, CN or NO 2 .

42. The compound of claim 41 of Formula (I-A):

or a pharmaceutically acceptable salt thereof, wherein:

X is S or O;

Cy A is a pyridinyl ring, wherein the pyridinyl ring is unsubstituted or substituted with 1, 2, or 3 R A ;

each R A is independently selected from halogen, CN, OH, C 1-6 alkyl, C 1-6 haloalkyl and C 1-6 alkoxy;

Cy B is a 3-aminopiperidin-1-yl, wherein the piperidinyl ring is optionally substituted with 1, 2, 3, or 4 R B ;

each R B is independently selected from halogen, C 1-6 alkyl, C 1-6 haloalkyl, C 3-7 cycloalkyl, CN, OH, C 1-6 alkoxy and NH 2 ;

R 2 is H, halogen or NH 2 ;

R 5 is H, halogen, R 5A , C 1-6 haloalkyl, CN or OR a3 ;

R 6 is H, halogen, R 6A , C 1-6 haloalkyl, CN or OR a4 ;

R 6A is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, phenyl, 5-6 membered heteroaryl or 4-7 membered heterocycloalkyl, wherein each of said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, phenyl, 5-6 membered heteroaryl or 4-7 membered heterocycloalkyl forming R 6A is unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents independently selected from C 1-6 alkyl, halogen, CN and OR a4 ;

R 7 is H, halogen, R 7A , C 1-6 haloalkyl, CN or OR a5 ;

R 7A is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, phenyl, 5-6 membered heteroaryl or 4-7 membered heterocycloalkyl forming R 7A is unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents independently selected from H, C 1-6 alkyl, halogen, CN and OR a5 ;

each R a3 is independently selected from H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl and C 3-7 cycloalkyl;

each R a4 is independently selected from H, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl and C 2-6 alkynyl; and

each R a5 is independently selected from H, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl and C 2-6 alkynyl.

43. The compound of claim 1 of Formula (II-5):

or a pharmaceutically acceptable salt thereof, wherein n RA is 0, 1, 2 or 3.

44. The compound of claim 1 of Formula (II-6):

or a pharmaceutically acceptable salt thereof, wherein n RA is 0, 1, 2 or 3.

45. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each R a1 , R b1 , R c1 , R d1 , R a2 , R b2 , R c2 , R a3 , R b3 , R c3 , R d3 , R a4 , R b4 , R c4 , R d4 , R a5 , R b5 , R c5 , R d5 , R a6 , R b6 , R c6 and R d6 is independently selected from H and C 1-6 alkyl and each R e1 , R e2 , R e3 , R e4 , R e5 and R e6 is independently selected from H and C 1-6 alkyl.

46. The compound of claim 1 selected from the following compounds:

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}-6-methoxythieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-methoxythieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-methoxythieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}-6-cyclopropoxythieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-cyclopropoxythieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-cyclopropoxythieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3-amino-5-methyl-piperidin-1-yl]pyridin-3-yl}-thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(cis-3-amino-5-methyl-piperidin-1-yl]pyridin-3-yl}-thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-methyl-piperidin-1-yl]pyridin-3-yl}-thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3-aminopiperidin-1-yl]pyridin-3-yl}-7-methoxythieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-7-methoxythieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-7-methoxythieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}-7-isopropoxythieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-7-isopropoxythieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-7-isopropoxythieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}-7-ethoxythieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-7-ethoxythieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-7-ethoxythieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}-6-ethylthieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-ethylthieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-ethylthieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}-6-phenylthieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-phenylthieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-phenylthieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}-6-(2,6-difluorophenyl)-thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-(2,6-difluorophenyl)-thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-(2,6-difluorophenyl)-thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}-6-(3,5-dimethylisoxazol-4-yl)-thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-(3, 5-dimethylisoxazol-4-yl)-thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-(3,5-dimethylisoxazol-4-yl)-thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}-6-(1-methylazetidin-3-yl)thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-(1-methylazetidin-3-yl)thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-(1-methylazetidin-3-yl)thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3-aminopiperidin-1-yl]pyridin-3-yl}-6-(1 isopropylazetidin-3-yl)thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-(4-isopropylazetidin-3-yl)thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-(1-isopropylazetidin-3-yl)thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3-aminopiperidin-1-yl]pyridin-3-yl}-6-(methoxymethyl)thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-(methoxymethyl)thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-(methoxymethyl)thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}-6-(tetrahydro-2H-pyran-4-yl)thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-(tetrahydro-2H-pyran-4-yl)thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-(tetrahydro-2H-pyran-4-yl)thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}-6-fluoro-thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-fluoro-thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-fluoro-thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}-7-trifluoromethyl-thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-7-trifluoromethyl-thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-7-trifluoromethyl-thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-[4-(3-aminopiperidin-1-yl)pyridin-3-yl]-5-chlorothieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-[4-((3S)-3-aminopiperidin-1-yl)pyridin-3-yl]-5-chlorothieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-[4-((3R)-3-aminopiperidin-1-yl)pyridin-3-yl]-5-chlorothieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-[4-(3-aminopiperidin-1-yl)pyridin-3-yl]-5-methylthieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-[4-((3S)-3-aminopiperidin-1-yl)pyridin-3-yl]-5-methylthieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-[4-((3R)-3-aminopiperidin-1-yl)pyridin-3-yl]-5-methylthieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3-aminopiperidin-1-yl]pyridin-3-yl}-6-ethylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-ethylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-ethylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}-6-(trifluoromethyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-(trifluoromethyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-(trifluoromethyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3-aminopiperidin-1-yl]pyridin-3-yl}-6-methyl-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-methyl-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-methyl-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}-6-(iso-propyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-(iso-propyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-(iso-propyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}-6-(propyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-(propyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-(propyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}-6-fluoro-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-fluoro-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-fluoro-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}-6-chloro-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-chloro-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-chloro-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}-6-bromo-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-bromo-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-6-bromo-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}-7-methyl-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-7-methyl-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-7-methyl-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-trifluoromethyl-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-trifluoromethyl-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-trifluoromethyl-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-chlorofuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-chlorofuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-chlorofuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-fluorofuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-fluorofuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-fluorofuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-methyl-piperidin-1-yl]pyridin-3-yl}-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-methyl-piperidin-1-yl]pyridin-3-yl}-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-methyl-piperidin-1-yl]pyridin-3-yl}-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-chlorofuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-chlorofuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-propylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-propylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-(trifluoromethyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-(trifluoromethyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-propylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-propylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-propylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-methyl-piperidin-1-yl]pyridin-3-yl}-6-propylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-methyl-piperidin-1-yl]pyridin-3-yl}-6-propylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-methyl-piperidin-1-yl]pyridin-3-yl}-6-propylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-methyl-piperidin-1-yl]pyridin-3-yl}-6-fluorofuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-methyl-piperidin-1-yl]pyridin-3-yl}-6-fluorofuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-methyl-piperidin-1-yl]pyridin-3-yl}-6-fluorofuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3-amino-5-methyl-piperidin-1-yl]pyridin-3-yl}-6-chlorofuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis3-amino-5-methyl-piperidin-1-yl]pyridin-3-yl}-6-chlorofuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-methyl-piperidin-1-yl]pyridin-3-yl}-6-chlorofuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-methyl-piperidin-1-yl]pyridin-3-yl}-6-(trifluoromethyl)-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-methyl-piperidin-1-yl]pyridin-3-yl}-6-(trifluoromethyl)-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-methyl-piperidin-1-yl]pyridin-3-yl}-6-(trifluoromethyl)-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-isopropylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-isopropylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{5-methyl-4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{5-methyl-4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{5-methyl-4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-propylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{5-methyl-4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-propylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{5-methyl-4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-chlorofuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{5-methyl-4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-chlorofuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{5-methyl-4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-(trifluoromethyl)-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{5-methyl-4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-(trifluoromethyl)-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-4-fluoro-piperidin-1-yl]pyridin-3-yl}-6-propylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[trans-3-amino-4-fluoro-piperidin-1-yl]pyridin-3-yl}-6-propylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R,4R)-3-amino-4-fluoro-piperidin-1-yl]pyridin-3-yl}-6-propylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-aminopiperidin-1-yl]pyridin-3-yl}-7-chloro-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}-7-chloro-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R)-3-aminopiperidin-1-yl]pyridin-3-yl}-7-chloro-furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-6-propylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R,4R,5S)-3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-6-propylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-4-hydroxy-4,5-dimethylpiperidin-1-yl]pyridin-3-yl}-6-propylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-4, 5-dimethylpiperidin-1-yl]pyridin-3-yl}-6-propylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-4-hydroxy-4,5-dimethylpiperidin-1-yl]pyridin-3-yl}-6-propylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R,4S,5S)-3-amino-4-hydroxy-4, 5-dimethylpiperidin-1-yl]pyridin-3-yl}-6-propylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-4-hydroxy-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-(tetrahydro-2H-pyran-4-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[trans-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-(tetrahydro-2H-pyran-4-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-(tetrahydro-2H-pyran-4-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-(1-methylpiperidin-4-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-(1-methylpiperidin-4-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-(1-methylpiperidin-4-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-(tetrahydro-2H-pyran-4-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-(tetrahydro-2H-pyran-4-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-(tetrahydro-2H-pyran-4-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-cyclobutylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-cyclobutylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-cyclobutylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-cyclobutylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-cyclobutylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-cyclobutylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[(3-fluoroazetidin-1-yl)methyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[(3-fluoroazetidin-1-yl)methyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-1-6-[(3-fluoroazetidin-1-yl)methyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[(3,3-difluoroazetidin-1-yl)methyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[(3,3-difluoroazetidin-1-yl)methyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[(3,3-difluoroazetidin-1-yl)methyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[(3-hydroxyazetidin-1-yl)methyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[(3-hydroxyazetidin-1-yl)methyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[(3-hydroxyazetidin-1-yl)methyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)piperidin-1-yl]pyridin-3-yl}-6-isopropylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R,4S,5S)-3-amino-5-methyl-4-(1H-1,2,3-triazol-1-yl)piperidin-1-yl]pyridin-3-yl}-6-isopropylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[(3-methoxypyrrolidin-1-yl)methyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[(3-methoxypyrrolidin-1-yl)methyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[(3-methoxypyrrolidin-1-yl)methyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[(3-ethoxypyrrolidin-1-yl)methyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[(3-ethoxypyrrolidin-1-yl)methyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[(3-ethoxypyrrolidin-1-yl)methyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-{[(3R)-3-fluoropyrrolidin-1-yl]methyl}furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-{[(3R)-3-fluoropyrrolidin-1-yl]methyl}furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-{[(3R)-3-fluoropyrrolidin-1-yl]methyl}furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-{[(3S)-3-fluoropyrrolidin-1-yl]methyl}furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-{[(3S)-3-fluoropyrrolidin-1-yl]methyl}furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-{[(3S)-3-fluoropyrrolidin-1-yl]methyl}furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[(4-methoxypiperidin-1-yl)methyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[(4-methoxypiperidin-1-yl)methyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[(4-methoxypiperidin-1-yl)methyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[(4-methylpiperazin-1-yl)methyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[(4-methylpiperazin-1-yl)methyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[(4-methylpiperazin-1-yl)methyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-(1-methyl-1H-pyrazol-4-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-(1-methyl-1H-pyrazol-4-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-(1-methyl-1H-pyrazol-4-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-(1-methyl-1H-pyrazol-4-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-(1-methyl-1H-pyrazol-4-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-(1-methyl-1H-pyrazol-4-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-pyrimidin-5-ylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-pyrimidin-5-ylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-pyrimidin-5-ylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-pyrimidin-5-ylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-pyrimidin-5-ylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-pyrimidin-5-ylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-cyclopropylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-cyclopropylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-cyclopropylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-cyclopropylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-cyclopropylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-cyclopropylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-methylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-methylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-methylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-methylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-methylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-methylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-ethylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-ethylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-ethylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-ethylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{ 4 -[cis)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-ethylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-ethylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}difluorophenyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}difluorophenyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3}-6-(2,6-difluorophenyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-(3-amino-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(difluoromethoxy)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-(cis-3-amino-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(difluoromethoxy)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-((3S, 5R)-3-amino-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(difluoromethoxy)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-(3-amino-5-methylpiperidin-1-yl)pyridin-3-yl)-6-isopropoxyfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-(cis-3-amino-5-methylpiperidin-1-yl)pyridin-3-yl)-6-isopropoxyfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-((3S, 5R)-3-amino-5-methylpiperidin-1-yl)pyridin-3-yl)-6-isopropoxyfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-(3-amino-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(tetrahydrofuran-3-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-(cis-3-amino-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(tetrahydrofuran-3-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-((3S, 5R)-3-amino-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(tetrahydrofuran-3-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-(tetrahydrofuran-3-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-(tetrahydrofuran-3-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-(tetrahydrofuran-3-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-cyclobutylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-cyclobutylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-6-cyclobutylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R,4R,5S)-3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl]pyridin-3-yl}-6-cyclobutylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-{6-[(methylamino)carbonyl]pyridin-3-yl}furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-{6-[(methylamino)carbonyl]pyridin-3-yl}furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-{6-[(methylamino)carbonyl]pyridin-3-yl}furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-(3-amino-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(6-(methylcarbamoyl)pyridin-3-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-(cis-3-amino-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(6-(methylcarbamoyl)pyridin-3-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-((3S, 5R)-3-amino-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(6-(methylcarbamoyl)pyridin-3-yl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-(3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl)pyridin-3-yl)-6-cyclopropylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-((3R,4R,5S)-3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl)pyridin-3-yl)-6-cyclopropylfuro[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-(3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl)pyridin-3-yl)-6-(trifluoromethyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-((3R,4R,5S)-3-amino-5-cyclopropyl-4-hydroxypiperidin-1-yl)pyridin-3-yl)-6-(trifluoromethyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-(3-methoxypropyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-(3-methoxypropyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-(3-methoxypropyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-(3-morpholin-4-ylpropyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-(3-morpholin-4-ylpropyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-(3-morpholin-4-ylpropyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-(3-methoxypropyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-(3-methoxypropyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyridin-3-yl}-6-(3-methoxypropyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[3-(dimethylamino)propyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[3-(dimethylamino)propyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-[3-(dimethylamino)propyl]furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-(3-fluoropropyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-(3-fluoropropyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-(3-fluoropropyl)furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-{2-[3-fluoropyrrolidin-1-yl]ethyl}furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[cis-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-{2-[3-fluoropyrrolidin-1-yl]ethyl}furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}-6-{2-[(3R)-3-fluoropyrrolidin-1-yl]ethyl}furo[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-(3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-isopropylthieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-isopropylthieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-(3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-propylthieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-propylthieno[3,2-b]pyridine-3-carboxamide;

6-(acetylamino)-2-amino-N-{4-[3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}thieno[3,2-b]pyridine-3-carboxamide;

6-(acetylamino)-2-amino-N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-(3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(cyclopropanecarboxamido)thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(cyclopropanecarboxamido)thieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-(3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-isobutyramidothieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-isobutyramidothieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-(3-amino-5-(trifluoromethyl)piperidin-1-yl)pyridin-3-yl)-6-morpholinothieno[3,2-b]pyridine-3-carboxamide;

2-amino-N-(4-(cis-3-amino-5-(trifluoromethyl)piperidin-1-yl)pyridin-3-yl)-6-morpholinothieno[3,2-b]pyridine-3-carboxamide; and

2-amino-N-(4-(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl)pyridin-3-yl)-6-morpholinothieno[3,2-b]pyridine-3-carboxamide;

or a pharmaceutically acceptable salt thereof.

47. A composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier.

48. A method of inhibiting Pim1, Pim2 or Pim3 enzyme comprising contacting the enzyme with a compound of claim 1 , or a pharmaceutically acceptable salt thereof.

Assignments (2)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 10, 2021

From: INCYTE CORPORATION

To: INCYTE CORPORATION; INCYTE HOLDINGS CORPORATION

Reel/Frame 058815/0857 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 16, 2015

From: LI, YUN-LONG; BURNS, DAVID M.; FENG, HAO; HUANG, TAISHENG; MEI, SONG; PAN, JUN; VECHORKIN, OLEG; YE, HAI-FEN; ZHU, WENYU; RAFALSKI, MARIA; WANG, ANLAI; XUE, CHU-BIAO

To: INCYTE CORPORATION

Reel/Frame 034738/0446 →