Method of making ligand functionalized substrates
View Patent ↗Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.
1. A ligand-functionalized substrate comprising
a) a base substrate, and grafted thereto
b) a ligand-functional copolymer comprising monomer units of the ligand monomer of the formula:
where
R 1 is H or C 1 -C 4 alkyl,
each R 3 is independently H or C 1 -C 4 alkyl,
R 4 is H, C 1 -C 4 alkyl or —N(R 3 ) 2 ,
X 1 is —O— or —NR 3 —, where R 3 is H or C 1 -C 4 alkyl,
R 7 and R 8 are each independently is C 1 to C 10 alkylene; and
Z is an ester, amide, urea, or urethane group.
2. The ligand functionalized substrate of claim 1 wherein the copolymer further comprises polymerized hydrophilic monomers.
3. The ligand functionalized substrate of claim 2 wherein the hydrophilic monomers are (meth)acryloylsulfonic acids or salts thereof of the formula
wherein, Y is a straight or branched alkylene and L is —O— or —NR 3 —, where R 3 is H or C 1 -C 4 alkyl.
4. The ligand functionalized substrate of claim 2 wherein the hydrophilic monomers are monoacrylated poly(alkylene oxide) compounds.
5. The ligand functionalized substrate of claim 2 wherein the hydrophilic monomers are of the formula:
where L is —O— or —NR 3 —, where R 3 is H or C 1 -C 4 alkyl; and Y is an alkylene, each R 11 is independently hydrogen, alkyl, hydroxyalkyl or aminoalkyl.
6. The ligand functionalized substrate of claim 1 wherein said substrate is a porous substrate having interstitial and outer surfaces.