Vascular closure device

1. A system for closing an opening formed through a wall of a body vessel of a patient, comprising:

an anchor body having a proximal end and a distal end, the anchor body including a plurality of hook members extending from a first end having a hook to a second end, the plurality of hook members being configured to engage interstitial tissue adjacent to said body vessel to inhibit movement of the anchor body,

wherein the anchor body is movable between a contracted configuration and an extended configuration, where in the contracted configuration the anchor body is sized to fit within a channel through said interstitial tissue, and in the extended configuration the hook members of the anchor body are displaced outward to a cross-sectional area greater than the cross-sectional area of said opening;

a plug member attached to the anchor body distal end, the plug member sized to at least substantially fill said opening, the hook members of the anchor body passing into the plug member and bending within the plug member such that the second ends extend outward past the plug member to form barbs configured to penetrate the area surrounding the opening from the interior of the body vessel; and

a retraction member removably attached to a portion of the anchor body, wherein the retraction member is retractable to bring the plug member in sealably contact with said opening.

2. The system of claim 1 , wherein the hook members of the anchor body in the extended configuration are disposed about a central axis at an acute angle.

3. The device of claim 1 , wherein the barbs point toward the proximal end of the anchor body.

4. The device of claim 1 , wherein the plug member is sized to extend between the proximal and distal ends of the anchor body and is configured to substantially fill said opening and a portion of the channel through the interstitial tissue.

5. The system of claim 1 , wherein when the retraction member is placed under tension to bring the hook members inward toward a central axis, and release of the tension permitting the hook members to move outward away from one another to the extended configuration.

6. The system of claim 1 , wherein the plug member comprises a remodelable material.

7. The system of claim 1 , wherein the anchor body comprises a biodegradable material.

8. The system of claim 1 , wherein a portion of the anchor body includes a coating comprising a therapeutic agent.

9. The system of claim 1 , wherein the hook members are attached to each other at a middle region.

10. The system of claim 1 , wherein the retraction member is looped through the hook members, tension on the retraction member urging the hook members to converge inward toward a central axis, and release of the tension permitting the hook members to move outward away from one another to the extended configuration.

11. The system of claim 1 , further comprising an eyelet disposed between the hook members, the retraction member being removably attached to the eyelet.

12. The system of claim 1 , wherein the distal end of the anchor body penetrates through the plug member.

13. The system of claim 1 , further comprising a sheath having a proximal end and a distal end, a distal portion of the sheath insertable through said opening, the sheath having a lumen extending therethrough, and a pusher disposed within the lumen of the sheath and movable within the sheath lumen, the pusher having a proximal end and a distal end, wherein the anchor body is disposed within the lumen of the sheath in the contracted configuration.

14. The system of claim 1 , wherein the hooks point toward the distal end of the anchor body.

15. The system of claim 1 , wherein when the retraction member is placed under tension to bring the hook members inward toward a central axis, and release of the tension permitting the hook members to move outward away from one another to the extended configuration, the hook members of the anchor body in the extended configuration are disposed about the central axis at an acute angle, the hooks point toward the distal end of the anchor body, further comprising a sheath having a proximal end and a distal end, a distal portion of the sheath insertable through said opening, the sheath having a lumen extending therethrough, and a pusher disposed within the lumen of the sheath and movable within the sheath lumen, the pusher having a proximal end and a distal end, wherein the anchor body is disposed within the lumen of the sheath in the contracted configuration.

16. The system of claim 15 , wherein the plug member comprises a remodelable material.

17. The system of claim 16 , wherein the barbs point toward the proximal end of the anchor body, the hook members are attached to each other at a middle region, and the distal end of the anchor body penetrates through the plug member.

18. The system of claim 15 , wherein the anchor body comprises a biodegradable material.

19. The system of claim 16 , wherein the barbs point toward the proximal end of the anchor body, the hook members are attached to each other at a middle region, and the distal end of the anchor body penetrates through the plug member.

20. The system of claim 1 , wherein the bending of the hook members within the plug member is at the surface of the plug member.