Granted Patent
B2
US 8,946,435 · App. 14/478,184 · Granted Feb 3, 2015
Synthesis for thiazolidinedione compounds
Inventors:
Steven P. Tanis (Carlsbad, CA); Timothy Parker (Portage, MI); Robert C. Gadwood (Portage, MI); James R. Zeller (Scottsdale, AZ); Gerald D. Artman, III (Schoolcraft, MI); Scott D. Larsen (South Lyon, MI)
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Abstract
The present invention provides novel methods for synthesizing PPARγ sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
Claims (4)
1. A compound selected from
wherein R 3 is hydrogen or an unsubstituted C 1-6 alkyl.
2. The compound of claim 1 , wherein R 3 is an unsubstituted C 1-6 alkyl.
3. The compound of claim 2 , wherein R 3 is methyl, ethyl, propyl, isopropyl, butyl, or tert-butyl, each of which is unsubstituted.
Assignments (4)
RELEASE OF SECURITY INTEREST
Recorded May 19, 2016
From: PACIFIC WESTERN BANK (AS SUCCESSOR IN INTEREST BY MERGER TO SQUARE 1 BANK)
To: METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC
Reel/Frame 038652/0097 →
SECURITY INTEREST
Recorded May 3, 2016
From: METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC
To: ALZHEIMER DRUG DISCOVERY FOUNDATION
Reel/Frame 038447/0317 →
SECURITY INTEREST
Recorded Jan 4, 2016
From: METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC
To: PACIFIC WESTERN BANK (AS SUCCESSOR IN INTEREST BY MERGER TO SQUARE 1 BANK)
Reel/Frame 037401/0277 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 9, 2014
From: TANIS, STEVEN P.; PARKER, TIMOTHY; GADWOOD, ROBERT C.; ZELLER, JAMES R.; LARSEN, SCOTT D.; ARTMAN, GERALD D., III
To: METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC
Reel/Frame 034434/0526 →
Continuity (3)
Division
13813462
Provisional Application
61377629
· Aug 27, 2010