MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME

1 . A compound of Formula I:

or pharmaceutically acceptable salt form or prodrug thereof, wherein:

Ring A is carbocyclyl or heterocyclyl optionally substituted by 1, 2, 3, 4 or 5 R 6 ;

W, X 1 , X 2 , Y 1 , and Y 2 are independently selected from (CR a R b ) t , (CR a R b ) u O(CR a R b ) v , (CR a R b ) u C(O)(CR a R b ) v , (CR a R b ) u C(O)NR c (CR a R b ) v , (CR a R b ) u C(O)O(CR a R b ) v , (CR a R b ) u C(S)(CR a R b ) u , (CR a R b ) u C(S)NR c (CR a R b ) v , (CR a R b ) u S(O)(CR a R b ) v , (CR a R b ) u S(O)NR c (CR a R b ) v , (CR a R b ) u S(O) 2 (CR a R b ) v , (CR a R b ) u S(O) 2 NR c (CR a R b ) v , (CR a R b ) u NR c (CR a R b ) v , and (CR a R b ) u C(═NR d )NR c (CR a R b ) v ;

R 1 is H, C(O)R 7 , C(O)NR 8a R 8b , C(O)OR 8 , C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, cycloalkylalkyl, heteroarylalkyl, or heterocycloalkylalkyl;

R 2 is H, C 1-6 alkyl, or C 3-7 cycloalkyl;

R 3a , R 4a , and R 5a are independently selected from C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, aryl, cycloalkyl, heteroaryl, and heterocycloalkyl, each optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl, Cy 1 , CN, NO 2 , OR e1 , SR e1 , C(O)R f1 , C(O)NR g1 R h1 , C(O)OR e1 , OC(O)R f1 , OC(O)NR g1 R h1 , NR g1 C(O)NR g1 R h1 , NR g1 R h1 , NR g1 C(O)R f1 , NR g1 C(O)OR e1 , C(═NR i )NR g1 R h1 , NR g1 C(═NR i )NR g1 R h1 , P(R f1 ) 2 , P(OR e1 ) 2 , P(O)R e1 R f1 , P(O)OR e1 OR f1 , S(O)R f1 , S(O)NR g1 R h1 , S(O) 2 R f1 , and S(O) 2 NR g1 R h1 ;

R 3b , R 4b , and R 5b are independently selected from H, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, aryl, cycloalkyl, heteroaryl, and heterocycloalkyl, each optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl, C 1-4 hydroxyalkyl, Cy 2 , CN, NO 2 , OR e1 , SR e1 , C(O)R f1 , C(O)NR g1 R h1 , C(O)OR e1 , OC(O)R f1 , OC(O)NR g1 R h1 , NR g1 C(O)NR g1 R h1 , NR g1 R h1 , NR g1 C(O)R f1 , NR g1 C(O)OR e1 , C(═NR i )NR g1 R h1 , NR g1 C(═NR i )NR g1 R h1 , P(R f1 ) 2 , P(OR e1 ) 2 , P(O)R e1 R f1 , P(O)OR e1 OR f1 , S(O)R f1 , S(O)NR g1 R h1 , S(O) 2 R f1 , and S(O) 2 NR g1 R h1 ;

or R 2 and —(R 3a ) a —(W) b —R 3b together with the N atom to which they are attached form a 4- to 20-membered heterocycloalkyl group optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl, Cy 3 , CN, NO 2 , OR e1 , SR e1 , C(O)R f1 , C(O)NR g1 R h1 , C(O)OR e1 , OC(O)R f1 , OC(O)NR g1 R h1 , NR g1 C(O)NR g1 R h1 , NR g1 R h1 , NR g1 C(O)R f1 , NR g1 C(O)OR e1 , C(═NR i )NR g1 R h1 , NR g1 C(═NR i )NR g1 R h1 , P(R f1 ) 2 , P(OR e1 ) 2 , P(O)R e1 R f1 , P(O)OR e1 OR f1 , S(O)R f1 , S(O)NR g1 R h1 , S(O) 2 R f1 , or S(O) 2 NR g1 R h1 ;

or —(Y 1 ) q —(R 4a )—(Y 2 ) s —R 4b and —(X 1 ) m —(R 5a ) n —(X 2 ) p —R 5b together with the N atom to which they are attached form a 4- to 20-membered heterocycloalkyl group optionally substituted by 1, 2, 3, 4 or 5 substituents selected from halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl, Cy 4 , CN, NO 2 , OR e1 SR e1 , C(O)R f1 , C(O)NR g1 R h1 , C(O)OR e1 , OC(O)R f1 , OC(O)NR g1 R h1 , NR g1 C(O)NR g1 R h1 , NR g1 R h1 , NR g1 C(O)R f1 , NR g1 C(O)OR e1 , C(═NR i )NR g1 R h1 , NR g1 C(═NR i )NR g1 R h1 , P(R f1 ) 2 , P(OR e1 ) 2 , P(O)R e1 R f1 , P(O)OR e1 OR f1 , S(O)R f1 , S(O)NR g1 R h1 , S(O) 2 R f1 , and S(O) 2 NR g1 R h1 ;

R 6 is halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, cycloalkylalkyl, heteroarylalkyl, heterocycloalkylalkyl, CN, NO 2 , OR e2 , SR e2 , C(O)R f2 , C(O)NR g2 R h2 , C(O)OR e2 , OC(O)R f2 , OC(O)NR g2 R h2 , NR g2 R h2 , NR g2 C(O)R f2 , NR g2 C(O)OR e2 , C(═NR i )NR g1 R h1 , NR g1 C(═NR i )NR g1 R h1 , P(R f2 ) 2 , P(OR e2 ) 2 , P(O)R e2 R f2 , P(O)OR e2 OR f2 , S(O)R f2 , S(O)NR g2 R h2 , S(O) 2 R f2 , or S(O) 2 NR g2 R h2 ;

R 7 and R 8 are independently selected from H, C 1-8 alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl, each optionally substituted by one or more substitutents independently selected from halo, CN, NO 2 , OH, C 1-4 alkoxy, C 1-4 haloalkoxy, amino, C 1-4 alkylamino, C 2-8 dialkylamino, C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl;

R 8a and R 8b are independently selected from H, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, cycloalkyl, arylalkyl, and cycloalkylalkyl;

Cy 1 , Cy 2 , Cy 3 , and Cy 4 are independently selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from halo, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, CN, NO 2 , OR e3 , SR e3 , C(O)R f1 , C(O)NR g3 R h3 , C(O)OR e3 , OC(O)R f1 , OC(O)NR g3 R h3 , NR g3 R h3 , NR g3 C(O)R h3 , NR g3 C(O)OR e3 , C(═NR i )NR g1 R h1 , NR g1 C(═NR i )NR g1 R h1 , P(R f1 ) 2 , P(OR e3 ) 2 , P(O)R e3 R f3 , P(O)OR e3 OR f3 , S(O)R f3 , S(O)NR g3 R h3 , S(O) 2 R f3 , and S(O) 2 NR g3 R h3 ;

R a and R b are independently selected from H, halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, cycloalkylalkyl, heteroarylalkyl, heterocycloalkylalkyl, CN, NO 2 , OR e4 , SR e4 , C(O)R f4 , C(O)NR g4 R h4 , C(O)OR e4 , OC(O)R f4 , OC(O)NR g4 R h4 , NR g4 R h4 , NR g4 C(O)R h4 , NR g4 C(O)OR e4 , C(═NR i )NR g1 R h1 , NR g1 C(═NR i )NR g1 R h1 , P(R f4 ) 2 , P(OR e4 ) 2 , P(O)R e4 R f4 , P(O)OR e4 OR f4 , S(O)R f4 , S(O)NR g4 R h4 , S(O) 2 R f4 , and S(O) 2 NR g4 R h4 ;

R c is H, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, cycloalkyl, arylalkyl, or cycloalkylalkyl;

R d is H, OR d1 , CN or NO 2 ;

R d1 is H, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, cycloalkyl, arylalkyl, or cycloalkylalkyl;

R e1 , R e2 , R e3 , and R e4 are independently selected from H, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, (C 1-6 alkoxy)-C 1-6 alkyl, C 2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, cycloalkylalkyl, heteroarylalkyl and heterocycloalkylalkyl;

R f1 , R f2 , R f3 , and R f4 are independently selected from H, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, cycloalkyl, heteroaryl and heterocycloalkyl;

R g1 , R g2 , R g3 , and R g4 are independently selected from H, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, cycloalkyl, arylalkyl, and cycloalkylalkyl;

R h1 , R h2 , R h3 , and R h4 are independently selected from H, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, cycloalkyl, arylalkyl, and cycloalkylalkyl;

or R g1 and R h1 together with the N atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group;

or R g2 and R h2 together with the N atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group;

or R g3 and R h3 together with the N atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group;

or R g4 and R h4 together with the N atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group;

R i is H, CN, or NO 2 ;

a is 0 or 1;

b is 0 or 1;

m is 0 or 1;

n is 0 or 1;

p is 0 or 1;

q is 0 or 1;

r is 0 or 1;

s is 0 or 1;

t is 1, 2, 3, 4, 5 or 6;

u is 0, 1, 2, 3, 4, 5 or 6; and

v is 0, 1, 2, 3, 4, 5 or 6;

with the provisos:

a) when Ring A is

R 2 is H;

—(Y 1 ) q —(R 4a ) r —(Y 2 ) s —R 4b is H; and

—(X 1 ) m —(R 5a ) n —(X 2 ) p —R 5b is H;

then —(R 3a ) a —(W)—R 3b is other than:

i) phenyl, 4-iodophenyl, 4-chlorophenyl, 4-bromophenyl, 4-methylphenyl, 3-methylphenyl, 2-methylphenyl, 2,4-dimethylphenyl, 2,6-dimethylphenyl, 2,5-dimethylphenyl, 3,4-dimethylphenyl, 2-methoxyphenyl, or 2-dimethylamino-5-nitrophenyl;

ii) —CH 2 CH 2 NR x R y , wherein each R x and R y is, independently, H, ethyl, —C(O)-oxadiazole optionally substituted with amino, or phenyl optionally having at least one substituent which is nitro; or

iii) C 1-3 alkyl, —C(O)—(C 1-4 haloalkyl), naphthyl, or benzyl;

b) when Ring A is phenyl having at least two substituents which are methyl;

—(Y 1 ) q —(R 4a ) r —(Y 2 ) s —R 4b is H; and

—(X 1 ) m —(R 5a ) n —(X 2 ) p —R 5b is H;

then —(R 3a ) a —(W)—R 3b is other than unsubstituted phenyl; and

c) when Ring A is phenyl having at least one substitutent which is nitro;

—(Y 1 ) q —(R 4a ) r —(Y 2 ) s —R 4b is H; and

—(X 1 ) m —(R 5a ) n —(X 2 ) p —R 5b is H;

then —(R 3a ) a —(W)—R 3b is other than pyrazolyl substituted by C 1 -4 alkyl.

2 - 8 . (canceled)

9 . The compound of claim 1 wherein Ring A is

10 . The compound of claim 1 wherein R 1 is H, C(O)R 7 , C(O)NR 8a R 8b , or C(O)OR 8 .

11 . The compound of claim 1 wherein R 1 is H.

12 . The compound of claim 1 wherein R 2 is H.

13 . The compound of claim 1 wherein a and b are both 0.

14 . (canceled)

15 . The compound of claim 1 wherein R 3b is aryl or heteroaryl each optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl, C 1-4 hydroxyalkyl, Cy 2 , CN, NO 2 , OR e1 , SR e1 , C(O)R f1 , C(O)NR g1 R h1 , C(O)OR e1 , OC(O)R f1 , OC(O)NR g1 R h1 , NR g1 C(O)NR g1 R h1 , NR g1 R h1 , NR g1 C(O)R f1 , NR g1 C(O)OR e1 , C(═NR i )NR g1 R h1 , NR g1 C(═NR i )NR g1 R h1 , P(R f1 ) 2 , P(OR e1 ) 2 , P(O)R e1 R f1 , P(O)OR e1 OR f1 , S(O)R f1 , S(O)NR g1 R h1 , S(O) 2 R f1 , and S(O) 2 NR g1 R h1 .

16 . The compound of claim 1 wherein R 3b is phenyl optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl, C 1-4 hydroxyalkyl, Cy 2 , CN, NO 2 , OR e1 , SR e1 , C(O)R f1 , C(O)NR g1 R h1 , C(O)OR e1 , OC(O)R f1 , OC(O)NR g1 R h1 , NR g1 C(O)NR g1 R h1 , NR g1 R h1 , NR g1 C(O)R f1 , NR g1 C(O)OR e1 , C(═NR i )NR g1 R h1 , NR g1 C(═NR i )NR g1 R h1 , P(R f1 ) 2 , P(OR e1 ) 2 , P(O)R e1 R f1 , P(O)OR e1 OR f1 , S(O)R f1 , S(O)NR g1 R h1 , S(O) 2 R f1 , and S(O) 2 NR g1 R h1 .

17 . The compound of claim 1 wherein r and s are both 0.

18 . The compound of claim 1 wherein q, r, and s are all 0.

19 . The compound of claim 1 wherein Y 1 is (CR a R b ) t or (CR a R b ) u C(O)(CR a R b ) v .

20 . The compound of claim 1 wherein R 4b is H.

21 . The compound of claim 1 wherein n and p are both 0.

22 . The compound of claim 1 wherein X 1 is (CR a R b ) t , (CR a R b ) u C(O)(CR a R b ) v , (CR a R b ) u C(O)NR c (CR a R b ) v , or (CR a R b ) u C(O)O(CR a R b ) v .

23 . The compound of claim 1 wherein R 5b is H, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, aryl, cycloalkyl, heteroaryl, or heterocycloalkyl, each optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl, C 1-4 hydroxyalkyl, Cy 2 , CN, NO 2 , OR e1 , SR e1 , C(O)R f1 , C(O)NR g1 R h1 , C(O)OR e1 , OC(O)R f1 , OC(O)NR g1 R h1 , NR g1 C(O)NR g1 R h1 , NR g1 R h1 , NR g1 C(O)R f1 , NR g1 C(O)OR e1 , C(═NR i )NR g1 R h1 , NR g1 C(═NR i )NR g1 R h1 , P(R f1 ) 2 , P(OR e1 ) 2 , P(O)R e1 R f1 , P(O)OR e1 OR f1 , S(O)R f1 , S(O)NR g1 R h1 , S(O) 2 R f1 , and S(O) 2 NR g1 R h1 .

24 . The compound of claim 1 wherein R 4b is H and R 5b is H, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, aryl, cycloalkyl, heteroaryl, or heterocycloalkyl, each optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-4 haloalkyl, C 1-4 hydroxyalkyl, Cy 2 , CN, NO 2 , OR e1 , SR e1 , C(O)R f1 , C(O)NR g1 R h1 , C(O)OR e1 , OC(O)R f1 , OC(O)NR g1 R h1 , NR g1 C(O)NR g1 R h1 , NR g1 R h1 , NR g1 C(O)R f1 , NR g1 C(O)OR e1 , C(═NR i )NR g1 R h1 , NR g1 C(═NR i )NR g1 R h1 , P(R f1 ) 2 , P(OR e1 ) 2 , P(O)R e1 R f1 , P(O)OR e1 OR f1 , S(O)R f1 , S(O)NR g1 R h1 , S(O) 2 R f1 , and S(O) 2 NR g1 R h1 .

25 . The compound of claim 1 wherein —(Y 1 ) q —(R 4a ) r —(Y 2 ) s —R 4b is H and —(X 1 ) m —(R 5a ) n —(X 2 ) p —R 5b is H.

26 - 30 . (canceled)

31 . A compound of claim 1 selected from:

4-Amino-N-(3-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide; 4-Amino-N′-hydroxy-N-phenyl-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(2-chlorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-chlorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(4-chlorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(4-bromophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N′-hydroxy-N-(2-methylphenyl)-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N′-hydroxy-N-(3-methylphenyl)-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N′-hydroxy-N-(4-methylphenyl)-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N′-hydroxy-N-[3-(trifluoromethyl)phenyl]-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N′-hydroxy-N-(2-methoxyphenyl)-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N′-hydroxy-N-(3-methoxyphenyl)-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N′-hydroxy-N-(4-methoxyphenyl)-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-[3-(benzyloxy)phenyl]-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

N-(3-Acetylphenyl)-4-amino-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-cyanophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3,4-difluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(4-bromo-3-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-chloro-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-chloro-4-methylphenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3,4-dimethylphenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-[4-(benzyloxy)-3-chlorophenyl]-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-[4-fluoro-3-(trifluoromethyl)phenyl]-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-benzyl-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(2-fluorobenzyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(2-chlorobenzyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-chlorobenzyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(4-chlorobenzyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N′-hydroxy-N-[3-(trifluoromethyl)benzyl]-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N′-hydroxy-N-(2-methoxybenzyl)-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N′-hydroxy-N-(pyridin-2-ylmethyl)-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N′-hydroxy-N-(2-phenylethyl)-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N′-hydroxy-N-1H-indol-5-yl-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-butyl-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

N-{4-[[(3-Chlorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-phenylacetamide;

N-{4-[[(3-Chlorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}benzamide;

N-{4-[(Benzylamino)(hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}benzamide;

N-benzyl-4-(benzylamino)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-[(Anilinocarbonyl)amino]-N-(3-chlorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-[Bis(anilinocarbonyl)amino]-N-(3-chlorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

tert-Butyl {4-[({4-[(E,Z)-[(3-chlorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}amino)carbonyl]benzyl}carbamate;

4-(Aminomethyl)-N-{4-[(E,Z)-[(3-chlorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}benzamide;

4-{[(Benzylamino)carbonyl]amino}-N-(3-bromo-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-bromo-4-fluorophenyl)-N′-hydroxy-1,2,5-thiadiazole-3-carboximidamide;

4-Amino-N-(6-chloropyridin-2-yl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-bromo-4-fluorophenyl)-N-hydroxyisothiazole-3-carboximidamide;

4-Amino-N-(2,5-dichlorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}morpholine-4-carboxamide;

N-(3-Bromo-4-fluorophenyl)-N′-hydroxy-4-(methylamino)-1,2,5-oxadiazole-3-carboximidamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}piperidine-4-carboxamide;

tert-Butyl 4-{4-[({4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}amino)carbonyl]benzyl}piperazine-1-carboxylate;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-4-(piperazin-1-ylmethyl)benzamide;

1-Benzoyl-N-{4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}piperidine-4-carboxamide;

N(4)-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-N(1)-phenylpiperidine-1,4-dicarboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-1-ethylpiperidine-4-carboxamide;

4-[(Benzoylamino)methyl]-N-{4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}benzamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(2-cyanophenoxy)acetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-4-phenylpiperidine-4-carboxamide;

N-(3-Bromo-4-fluorophenyl)-4-({4-[(1,1-dioxidothiomorpholin-4-yl)methyl]benzyl}amino)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

N-(3-Bromo-4-fluorophenyl)-N-hydroxy-4-{[4-(morpholin-4-ylmethyl)benzyl]amino}-1,2,5-oxadiazole-3-carboximidamide;

N-(3-Cyano-4-fluorophenyl)-4-({4-[(1,1-dioxidothiomorpholin-4-yl)methyl]benzyl}amino)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

N-(3-Bromo-4-fluorophenyl)-N-hydroxy-4-[(pyridin-3-ylmethyl)amino]-1,2,5-oxadiazole-3-carboximidamide;

N-(3-Cyano-4-fluorophenyl)-N-hydroxy-4-[(pyridin-4-ylmethyl)amino]-1,2,5-oxadiazole-3-carboximidamide;

4-[(3-Cyanobenzyl)amino]-N-(3-cyano-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

N-(3-Bromo-4-fluorophenyl)-N-hydroxy-4-[(1H-tetrazol-5-ylmethyl)amino]-1,2,5-oxadiazole-3-carboximidamide;

N-(Acetyloxy)-4-amino-N-(3-chloro-4-fluorophenyl)-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-chloro-4-fluorophenyl)-N-(propionyloxy)-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N′-{[(b enzylamino)carbonyl]oxy}-N-(3-chloro-4-fluorophenyl)-1,2,5-oxadiazole-3-carboximidamide;

N-(3-Bromo-4-fluorophenyl)-N-hydroxy-4-morpholin-4-yl-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-hydroxy-N-[3-(3-hydroxyprop-1-yn-1-yl)phenyl]-1,2,5-oxadiazole-3-carboximidamide;

N-{4-[(E,Z)-[(3-Chlorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}cyclopentanecarboxamide;

N-{4-[(E,Z)-[(3-Chlorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}nicotinamide;

N-{4-[(E,Z)-[(3-Chlorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}isonicotinamide;

N-{4-[(E,Z)-[(3-Chlorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-methoxybenzamide;

N-{4-[(E,Z)-[(3-Chlorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-methoxybenzamide;

N-{4-[(E,Z)-[(3-Chlorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-4-methoxybenzamide;

2-Chloro-N-{4-[(E,Z)-[(3-chlorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}benzamide;

3-Chloro-N-{4-[(E,Z)-[(3-chlorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}benzamide;

4-Chloro-N-{4-[(E,Z)-[(3-chlorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}benzamide;

N-{4-[(E,Z)-[(3-Chlorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3,3-dimethylbutanamide;

4-Amino-N-(3-bromophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-bromo-4-methylphenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-chloro-4-methoxyphenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3,5-dimethylphenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-hydroxy-N-(2-methylbenzyl)-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N′-hydroxy-N-(3-methylbenzyl)-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-hydroxy-N-(4-methylbenzyl)-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N′-hydroxy-N-[2-(trifluoromethyl)benzyl]-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N′-hydroxy-N-[4-(trifluoromethyl)benzyl]-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-ethylphenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3,4-dichlorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3,5-dichlorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-biphenyl-3-yl-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(2-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-chloro-4-methylbenzyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(2,3-dimethylphenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

N-{4-[(E,Z)-[(3-Chlorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-4-iodobenzamide;

4-Amino-N-(4-chloro-3-methylphenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-hydroxy-N-[3-(methylthio)phenyl]-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-chloro-2-methylphenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-fluoro-2-methylphenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N′-hydroxy-N-(3-vinylphenyl)-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-ethynylphenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(4-fluoro-3-methylphenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-hydroxy-N-(3-iodophenyl)-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-hydroxy-N-(3-isopropylphenyl)-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-bromo-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N′-hydroxy-N-(4-phenylbutyl)-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N′-hydroxy-N-[3-(1,3-oxazol-5-yl)phenyl]-1,2,5-oxadiazole-3-carboximidamide;

N-{4-[(E,Z)-[(3-Chlorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-4-cyanobenzamide;

4-Amino-N-hydroxy-N-[1-phenylethyl]-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-hydroxy-N-1-naphthyl-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-hydroxy-N-2-naphthyl-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-chloro-2-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

N-{4-[(E,Z)-{[4-Fluoro-3-(trifluoromethyl)phenyl]amino}(hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}nicotinamide;

N-{4-[(E,Z)-{[4Fluoro-3-(trifluoromethyl)phenyl]amino}(hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}isonicotinamide;

4-Amino-N-(3-cyclopropylphenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}benzamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}nicotinamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}isonicotinamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-4-cyanobenzamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-cyanobenzamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-naphthamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-1-naphthamide;

1-Acetyl-N-{4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}piperidine-4-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-furamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}thiophene-2-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide;

4-(Acetylamino)-N-{4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}benzamide

tert-Butyl {4-[({4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}amino)carbonyl]benzyl}carbamate

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-1-benzothiophene-2-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-1,3-thiazole-4-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-1-benzothiophene-3-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}thiophene-3-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-1H-imidazole-2-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-4-methyl-1,2,3-thiadiazole-5-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-1,2,3-thiadiazole-4-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2,1-benzisoxazole-3-carboxamide;

4-(Aminomethyl)-N-{4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}benzamide;

N-(3-Bromo-4-fluorophenyl)-N-hydroxy-4-({[(2-phenylethyl)amino]carbonyl}amino)-1,2,5-oxadiazole-3-carboximidamide;

N-(3-Bromo-4-fluorophenyl)-4-{[(cyclopentylamino)carbonyl]amino}-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

N-(3-Bromo-4-fluorophenyl)-4-({[(3-cyanophenyl)amino]carbonyl}amino)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-tert-butyl-1-methyl-1H-pyrazole-5-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-methoxyacetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}cyclopentanecarboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}butanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-methylpropanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}propanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}cyclohexanecarboxamide;

4-Amino-N-(2,3-dichlorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-chlorophenyl)-N′-hydroxy-N-methyl-1,2,5-oxadiazole-3-carboximidamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-1H-benzimidazole-5-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-phenoxyacetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}cyclobutanecarboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-methylbutanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-pyridin-3-ylpropanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}quinoline-6-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(4-chlorophenoxy)acetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(4-bromophenoxy)acetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(4-fluorophenoxy)acetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(4-tert-butylphenoxy)acetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(3-chlorophenoxy)acetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(3,4-dichlorophenoxy)acetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(2-naphthyloxy)acetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(2,3-dichlorophenoxy)acetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(4-chlorophenoxy)-2-methylpropanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(2-chlorophenoxy)acetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(3-methoxyphenoxy)acetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(4-methoxyphenoxy)acetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(2-methoxyphenoxy)acetamide;

Benzyl {4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}carbamate;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}acetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}piperidine-1-carboxamide;

N-(3-Bromo-4-fluorophenyl)-4-({[(3-cyanophenyl)(methyl)amino]carbonyl}amino)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N′-hydroxy-N-(6-methylpyridin-2-yl)-1,2,5-oxadiazole-3-carboximidamide;

4-({[Benzyl(methyl)amino]carbonyl}amino)-N-(3-bromo-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-phenylacetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(3-methoxyphenyl)acetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(4-methoxyphenyl)acetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(2-methoxyphenyl)acetamide;

4-Amino-N-(2,4-dichlorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-cyanobenzamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-(3-bromophenyl)propanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-(4-bromophenyl)propanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-(4-chlorophenyl)propanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-(3-chlorophenyl)propanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-(2-fluorophenyl)propanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-(3-fluorophenyl)propanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-(2-chlorophenyl)propanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-(3-methylphenyl)propanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-(3-(trifluoromethyl)phenyl)propanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-(4-fluorophenyl)propanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-(2-methoxyphenyl)propanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-(3-methoxyphenyl)propanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-(4-methoxyphenyl)propanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-(4-methylphenyl)propanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-[4-(trifluoromethyl)phenyl]propanamide;

3-[2,5-Bis(trifluoromethyl)phenyl]-N-{4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}propanamide;

3-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}propanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-methyl-3-phenylpropanamide;

2-Benzyl-N-{4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3,3-dimethylbutanamide;

4-Amino-N-(5-chloro-2-methoxyphenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(5-chloro-2-methylphenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(5-chloro-2-nitrophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(5-chloro-2-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidine-4-carboxamide;

1-Benzyl-N-{4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-tert-butyl-1H-pyrazole-5-carboxamide;

2-(Benzyloxy)-N-{4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}acetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-1-(4-chlorophenyl)cyclopentanecarboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-phenoxybenzamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2,4,6-trichlorobenzamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-methoxybenzamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-methoxybenzamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2,2-diphenylacetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-4-(trifluoromethoxy)benzamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-4-methoxybenzamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3,4-dimethoxybenzamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(2-nitrophenoxy)acetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-chloronicotinamide trifluoroacetate;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}biphenyl-4-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(2,6-dichlorobenzyl)-1,3-thiazole-4-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2,6-dimethoxybenzamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-4-nitrobenzamide;

5-Bromo-N-{4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}nicotinamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3,3-dimethylbutanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(2-thienyl)acetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-4-phenylbutanamide;

4-Amino-N-(2-bromo-5-chlorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2,2-dimethylpropanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-4-(morpholin-4-ylmethyl)benzamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-4-[(1,1-dioxidothiomorpholin-4-yl)methyl]benzamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-1-(phenylacetyl)piperidine-4-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-1-(methylsulfonyl)piperidine-4-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-pyridin-4-yl-1,3-thiazole-4-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-nitrobenzamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-nitrobenzamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-1-isopropylpiperidine-4-carboxamide;

tert-Butyl 4-{4-[({4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}amino)carbonyl]-1,3-thiazol-2-yl}piperidine-1-carboxylate;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-phenyl-1,3-thiazole-4-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-methyl-1,3-thiazole-4-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-piperidin-4-yl-1,3-thiazole-4-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(4-cyanophenoxy)acetamide;

tert-Butyl 3-[({4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}amino)carbonyl]piperidine-1-carboxylate;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-3-(3-nitrophenyl)propanamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(3-nitrophenoxy)acetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(4-nitrophenoxy)acetamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}piperidine-3-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-4-methyl-2-pyridin-3-yl-1,3-thiazole-5-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-4-methyl-1,3-thiazole-5-carboxamide;

2-Amino-N-{4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-1,3-thiazole-4-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-4-methyl-2-pyrazin-2-yl-1,3-thiazole-5-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2,4-dimethyl-1,3-thiazole-5-carboxamide;

1-Acetyl-N-{4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}pyrrolidine-2-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-1,5-dimethyl-1H-pyrazole-3-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-5-chloro-1-methyl-1H-pyrazole-4-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-1,3-dimethyl-1H-pyrazole-5-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-1-methyl-1H-imidazole-2-carboxamide;

4-[(Acetylamino)methyl]-N-{4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}benzamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-4-methylpiperidine-4-carboxamide;

1-Acetyl-N-{4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}piperidine-3-carboxamide;

1-Acetyl-N-{4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-4-methylpiperidine-4-carboxamide;

1-Acetyl-N-{4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-4-phenylpiperidine-4-carboxamide;

4-(Benzylamino)-N-(3-bromo-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-1-ethylpiperidine-3-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-4-ethylpiperazine-1-carboxamide;

4-Acetyl-N-{4-[(E,Z)-[(3-bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}piperazine-1-carboxamide;

N-{4-[(E,Z)-[(3-Bromo-4-fluorophenyl)amino](hydroxyimino)methyl]-1,2,5-oxadiazol-3-yl}-2-(1-ethylpiperidin-4-yl)-1,3-thiazole-4-carboxamide;

4-Amino-N-(3-cyano-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

N-(3-Bromo-4-fluorophenyl)-N′-hydroxy-4-[(1,3-thiazol-4-ylmethyl)amino]-1,2,5-oxadiazole-3-carboximidamide;

N-(3-Bromo-4-fluorophenyl)-4-[(4-cyanobenzyl)amino]-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-chloro-5-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-[3-(difluoromethyl)phenyl]-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

N-(3-Bromo-4-fluorophenyl)-N′-hydroxy-4-{[(1-methylpiperidin-4-yl)methyl]amino}-1,2,5-oxadiazole-3-carboximidamide;

N-(3-Bromo-4-fluorophenyl)-N-hydroxy-4-{[4-(piperazin-1-ylmethyl)benzyl]amino}-1,2,5-oxadiazole-3-carboximidamide;

N-(3-Bromo-4-fluorophenyl)-4-({4-[(4-ethylpiperazin-1-yl)methyl]benzyl}amino)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-hydroxy-N-(3-hydroxyphenyl)-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-chloro-4-fluorophenyl)-N-(isobutyryloxy)-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-chloro-4-fluorophenyl)-N′-[(3-methylbutanoyl)oxy]-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(benzoyloxy)-N-(3-chloro-4-fluorophenyl)-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-chloro-4-fluorophenyl)-N′-[(2,2-dimethylpropanoyl)oxy]-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-[3-(cyanomethyl)phenyl]-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-(3-cyano-2-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N′-hydroxy-N-[3-(methoxymethyl)phenyl]-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-hydroxy-N-[3-(3-methoxyprop-1-yn-1-yl)phenyl]-1,2,5-oxadiazole-3-carboximidamide;

4-Amino-N-hydroxy-N-(2-methyl-1,3-benzoxazol-4-yl)-1,2,5-oxadiazole-3-carboximidamide;

4-Anilino-N-(3-bromo-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide;

N-(3-Bromo-4-fluorophenyl)-N-hydroxy-4-[(pyridin-4-ylmethyl)amino]-1,2,5-oxadiazole-3-carboximidamide; and

N-(3-Bromo-4-fluorophenyl)-4-[(3-cyanobenzyl)amino]-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide, or pharmaceutically acceptable salt thereof.

32 . A composition comprising a compound of claim 1 , or pharmaceutically acceptable salt form thereof.

33 . A method of modulating activity of indoleamine 2,3-dioxygenase comprising contacting said indoleamine 2,3-dioxygenase with a compound of claim 1 , or pharmaceutically acceptable salt thereof.

34 . The method of claim 33 wherein said modulating is inhibiting.

35 . A method of inhibiting immunosuppression in a patient comprising administering to said patient an effective amount of a compound of claim 1 , or pharmaceutically acceptable salt thereof.

36 . A method of treating cancer, viral infection, depression, a neurodegenerative disorder, trauma, age-related cataracts, organ transplant rejection, or an autoimmune disease in a patient comprising administering to said patient a therapeutically effective amount of a compound of claim 1 , or pharmaceutically acceptable salt thereof.

37 . The method of claim 36 further comprising administration of an anti-viral agent, a chemotherapeutic, an immunosuppressant, radiation, an anti-tumor vaccine, an anti-viral vaccine, cytokine therapy, or a tyrosine kinase inhibitor.