Methods for treating edema in the eye and intraocular implants for use therefor
Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer.
1. A method for treating edema in an eye of an individual in need thereof, comprising: placing a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer in an eye of an individual, thereby treating edema of the eye of the individual, wherein the immunosuppressive agent comprises about 50% by weight to about 80% by weight of the drug delivery system, based on the total weight of the drug delivery system.
2. The method of claim 1 , wherein the biodegradable drug delivery system is placed in the vitreous of the eye.
3. The method of claim 1 , wherein the bioerodible polymer comprises a polylactic acid polyglycolic acid (PLGA) copolymer.
4. The method of claim 1 , wherein the bioerodible drug delivery system delivers the immunosuppressive agent for at least 5 days.
5. The method of claim 1 , wherein the bioerodible drug delivery system delivers the immunosuppressive agent for at least about 3 weeks.
6. The method of claim 1 , wherein the immunosuppressive agent comprises dexamethasone.