Treatment and prevention of radiation injury using MFG-E8
View Patent ↗Methods and compositions are disclosed for treating and preventing radiation injury using milk fat globule epidermal growth factor-factor VIII (MFG-E8).
1. A method of treating radiation damage in a subject exposed to radiation therapy for treatment of a disease comprising administering to the subject a milk fat globule epidermal growth factor-factor VIII (MFG-E8) in an amount effective to reduce radiation-induced intestinal epithelial cell death in a subject following exposure to radiation therapy for treatment of a disease, wherein MFG-E8 is administered to the subject either before radiation therapy or within 24 hours after onset of radiation therapy.
2. The method of claim 1 , wherein the disease is cancer.
3. The method of claim 1 , wherein treatment of the subject with MFG-E8 reduces a decrease in body weight following exposure to radiation.
4. The method of claim 1 , wherein treatment of the subject with MFG-E8 reduces a decrease in MFG-E8 following exposure to radiation.
5. The method of claim 1 , wherein the MFG-E8 is a recombinant human MFG-E8 (rhMFG-E8).
6. The method of claim 5 , wherein the rhMFG-E8 has an amino acid sequence that is at least 95% identical to human MFG-E8 (hMFG-E8) (SEQ ID NO:1).
7. The method of claim 1 , wherein the MFG-E8 is a human MFG-E8.
8. The method of claim 7 , wherein the MFG-E8 has an amino acid sequence that is at least 95% identical to human MFG-E8 (SEQ ID NO:1).
9. The method of claim 1 , wherein the MFG-E8 is non-glycosylated.
10. The method of claim 1 , wherein the subject does not have sepsis.