Pain relief compositions, manufacture and uses
The present invention relates to TRPV1 selective agonist topical compositions including capsaicinoid and analgesic agent compositions and methods of manufacture and methods of providing pain relief as well as treating a variety of disorders with such compositions.
1. A composition comprising:
i) 2-30% by weight of a capsaicinoid, and
ii) 50-95% by weight of an analgesic agent comprising a) a topical salicylate and b) a TRPM8 agonist, capable of solubilizing said capsaicinoid,
wherein said topical salicylate solubilizes said capsaicinoid, and wherein said composition comprises an amount of analgesic agent sufficient to eliminate or reduce the burning or stinging sensation or erythema created by the topical administration of the capsaicinoid to a mammal,
wherein the composition is in a form selected the group consisting of sprays, gels, emulsions, and mixtures thereof, and
wherein said TRPM8 agonist is icilin or eucalyptol.
2. The composition as claimed in claim 1 , wherein said analgesic agent comprises the topical salicylate, the TRPM8 agonist, and a TRPV3 agonist.
3. The composition as claimed in claim 1 , wherein said composition is a gel.
4. The composition as claimed in claim 1 , wherein said capsaicinoid is capsaicin.
5. The composition as claimed in claim 1 , wherein said capsaicinoid is trans-capsaicin or nonivamide.
6. The composition as claimed in claim 1 , wherein said TRPM8 agonist is eucalyptol.
7. The composition as claimed in claim 2 , wherein the TRPV3 agonist is camphor.
8. The composition as claimed in claim 1 , wherein said analgesic agent comprises i) methyl salicylate and ii) at least one of menthol, camphor and phenol.
9. The composition as claimed in claim 1 , wherein said composition further comprises an alcohol.
10. The composition as claimed in claim 1 , wherein said composition comprises:
2-30% by weight of a capsaicinoid,
30-70% by weight methyl salicylate,
1-20% by weight menthol, and
1-20% by weight camphor,
wherein the percentage by weight of the methyl salicylate, menthol, and camphor is greater than 50% of the composition.
11. The composition as claimed in claim 1 , wherein said composition comprises:
2-30% by weight of a capsaicinoid,
30-75% by weight methyl salicylate and ethanol,
1-20% by weight menthol, and
1-20% by weight camphor,
wherein the percentage by weight of the methyl salicylate, menthol, and camphor is greater than 50% of the composition.
12. The composition as claimed in claim 1 , wherein said composition comprises:
2-30% by weight of a capsaicinoid,
40-75% by weight methyl salicylate,
10-25% ethanol,
10-20% by weight menthol, and
10-20% by weight camphor.
13. The composition as claimed in claim 1 , wherein said composition comprises:
2-30% by weight of capsaicin,
40-75% by weight methyl salicylate
10-25% ethanol,
10-20% by weight menthol,
10-20% by weight camphor, and
0.5-5% phenol.
14. The composition as claimed in claim 11 , wherein said composition further comprises glycerol.
15. The composition as claimed in claim 14 , wherein said composition is a gel.
16. The composition as claimed in claim 1 , wherein said composition further comprises an anti-inflammatory agent.
17. The composition as claimed in claim 1 , wherein said composition further comprises a surfactant.
18. The composition as claimed in claim 1 , wherein said composition further comprises an NSAID.
19. The composition as claimed in claim 18 , wherein the NSAID is selected from the group consisting of aspirin, ibuprofen, naproxen, ketoprofen, and diclofenac.
20. The composition as claimed in claim 1 , wherein said composition further comprises an odor reducing agent.
21. The composition as claimed in claim 1 , wherein said composition further comprises phenol.
22. The composition as claimed in claim 11 , wherein said composition further comprises phenol.
23. A composition comprising:
2-30% by weight of a capsaicinoid,
icilin or eucalyptol,
methyl salicylate and ethyl alcohol, and
phenol,
wherein said methyl salicylate and ethyl alcohol solubilize said capsaicinoid,
wherein the percentage by weight of the methyl salicylate and phenol is greater than 50% of the composition, and
wherein the composition is in a form selected the group consisting of sprays, gels, emulsions, and mixtures thereof.
24. The composition as claimed in claim 23 , wherein said composition comprises:
2-30% by weight of a capsaicinoid compound,
30-75% by weight methyl salicylate and ethyl alcohol,
and
0.5-5% phenol.
25. A composition comprising:
2-30% by weight of a capsaicinoid,
70-95% by weight of an analgesic agent comprising a topical salicylate, and
icilin or eucalyptol,
wherein said topical salicylate solubilizes said capsaicinoid, and
wherein said composition comprises an amount of analgesic agent sufficient to eliminate or reduce the burning or stinging sensation or erythema created by the topical administration of the capsaicinoid to a mammal, wherein said composition does not include turpentine oil, and
wherein the composition is in a form selected the group consisting of sprays, gels, emulsions, and mixtures thereof.
26. The composition as claimed in claim 25 , wherein said analgesic agent comprises a topical salicylate and a TRPM8 agonist.
27. The composition as claimed in claim 25 , wherein the composition is a gel.
28. The composition as claimed in claim 25 , wherein said analgesic agent is i) methyl salicylate and ii) at least one of menthol, camphor and phenol.
29. The composition as claimed in claim 25 , wherein said composition further comprises an alcohol.
30. The composition as claimed in claim 26 wherein said composition further comprises a TPRV3 agonist.
31. The composition as claimed in claim 27 , wherein said gel comprises capsaicin, methyl salicylate, camphor and menthol.