Granted Patent B2

US 9,308,295 · App. 14/485,376 · Granted Apr 12, 2016

Abstract

Claims (23)

1. A non-emulsified composition, consisting of:

demineralized bone matrix (DBM) powder, granules and/or fibers coated with a perfluorocarbon; and

optionally consisting of a handling agent selected from the group consisting of saline, glycerols, polyoxamers, lecithins, and combinations thereof.

2. The non-emulsified composition of claim 1 , wherein the perfluorocarbon has a boiling point at or within the range of about 50° C. to about 250° C.

3. The non-emulsified composition of claim 1 , wherein the perfluorocarbon has a boiling point at or within the range of about 140° C. to about 145° C.

4. The non-emulsified composition of claim 1 , wherein the perfluorocarbon is selected from the group consisting of perfluorodecalin, perfluorohexane, perfluoroperhydrophenanthrene, perfluorobutylamine (PFTBA), perfluorooctylbromide (PFOB), perfluoro-n-octane, octafluoropropane, perfluorodichlorooctane, perfluorodecane, perfluorotripropylamine, perfluorotrimethylcyclohexane, perfluoromethyladamantane, perfluorodimethyladamantane, perfluoromethyldecaline, perfluorofluorene, diphenyldimethylsiloxane, hydrogen-rich monohydroperfluorooctane, alumina-treated perfluorooctane, and mixtures thereof.

5. The non-emulsified composition of claim 1 , wherein the perfluorocarbon is perfluorodecalin, perfluorohexane, perfluorobutylamine, perfluoroperhydrophenanthrene, or mixtures thereof.

6. The non-emulsified composition of claim 1 , wherein the perfluorocarbon is perfluorodecalin.

7. The non-emulsified composition of claim 1 , wherein the perfluorocarbon is in an amount greater than 5% (w/w) based on the total weight of the perfluorocarbon and the DBM combined.

8. The non-emulsified composition of claim 1 , wherein the perfluorocarbon is in an amount from about 10 to about 70% by weight based on the total weight of the perfluorocarbon and the DBM combined.

9. The non-emulsified composition of claim 1 , wherein the perfluorocarbon is in an amount from about 32 to about 48% by weight based on the total weight of the perfluorocarbon and the DBM combined.

10. The non-emulsified composition of claim 1 used for enhancing bone growth.

11. The non-emulsified composition of claim 1 , wherein the DBM is in the form of powder and/or granules.

12. The non-emulsified composition of claim 11 , wherein the DBM is in the form of fibers.

13. A method of making a non-emulsified composition for bone growth, the method consisting of:

coating a perfluorocarbon on DBM powder, granules, and/or fibers to form a non-emulsified mixture; and

optionally adding a handling agent to the non-emulsified mixture, the handling agent being selected from the group consisting of saline, glycerols, polyoxamers, lecithins, and combinations thereof.

14. The method of claim 13 , wherein the perfluorocarbon has a boiling point at or within the range of about 50° C. to about 250° C.

15. The method of claim 13 , wherein the perfluorocarbon is selected from the group consisting of perfluorodecalin, perfluorohexane, perfluoroperhydrophenanthrene, perfluorobutylamine (PFTBA), perfluorooctylbromide (PFOB), perfluoro-n-octane, octafluoropropane, perfluorodichlorooctane, perfluorodecane, perfluorotripropylamine, perfluorotrimethylcyclohexane, perfluoromethyladamantane, perfluorodimethyladamantane, perfluoromethyldecaline, perfluorofluorene, diphenyldimethylsiloxane, hydrogen-rich monohydroperfluorooctane, alumina-treated perfluorooctane, and mixtures thereof.

16. The method of claim 13 , wherein the perfluorocarbon is perfluorodecalin.

17. The method of claim 13 , wherein the perfluorodecalin is in an amount greater than 5% (w/w) based on the total weight of the non-emulsified mixture.

18. The method of claim 13 , wherein the DBM is in the form of powder and/or granules.

19. The method of claim 13 , wherein the DBM is in the form of fibers.

Assignments (8)