DEVICES FOR THE TREATMENT OF VASCULAR ANEURYSM
Devices for the treatment of vascular aneurysms are described. The treatment is achieved through the delivery of an effective amount of elastin stabilization agent to an isolated volume at the aneurysm. The elastin stabilization agent maybe embedded in a delivery composition. The device optionally has an aspiration means to improve the effectiveness of the treatment.
1 . A method for treating an isolated portion of a blood vessel, the method comprising:
delivering a therapeutic composition to the isolated volume of the blood vessel following aspiration of the fluid using a device that is positioned within the vessel with an extendable portion forming the isolated volume with the wall of the vessel wherein the therapeutic composition is delivered into the isolated volume through a fluid exchange portion in fluid communication with a lumen of the shaft that extends from the patient wherein the flow in the vessel is maintained through a by pass channel of the delivery device while treatment is performed, wherein the therapeutic composition comprises an elastin stabilizing composition.
2 . The method of claim 1 wherein the shaft further comprises a rapid exchange guidewire lumen with a guidewire port near the distal end of the shaft.
3 . The method of claim 1 wherein the extendable element comprises an actuation element that controls the transition of the extendable element between the lower profile configuration and the extended configuration.
4 . The method of claim 1 wherein the fluid exchange portion is on the shaft of the device comprising one or more exchange openings in fluid communication with the isolated volume.
5 . The method of claim 4 wherein the one or more exchange openings comprises a tubular conduit displaced from the shaft having an opening that is in fluid communication with the isolated volume.
6 . The method of claim 4 wherein the fluid exchange portion comprises a side channel that is a portion of the second lumen having an opening on the side of the sealing element of the device.
7 . The method of claim 6 further comprises a micro-catheter placed inside the side channel and the second lumen to go through the opening on the side of the sealing element to access the isolated volume.
8 . The method of claim 4 wherein the one or more exchange openings comprises a liquid permeable structure.
9 . The method of claim 1 wherein the device further comprises an aspiration apparatus operably connected to the port of the second lumen of the shaft.
10 . The method of claim 9 wherein the aspiration apparatus comprises a syringe.
11 . The method of claim 1 wherein the device further comprising a delivery element operably connected to the port of the second lumen and an aspiration apparatus, wherein the shaft further comprises a third lumen in fluid communication with the isolated volume with the aspiration apparatus operably connected to the port of the third lumen.
12 . The method of claim 1 wherein the extendable element comprises two balloons that are inflated in the extended configuration and deflated in the lower profile configuration and wherein both balloons are in fluid communication with the first lumen of the shaft to form the isolated volume between the two balloons.
13 . The method of claim 1 wherein the stabilizing liquid comprises glutaraldehyde.
14 . The method of claim 1 wherein the elastin stabilizing composition comprises pentagalloyl glucose.
15 . The method of claim 1 wherein the isolated portion of the blood vessel comprises an aneurysm.
16 . The method of claim 1 further comprising aspirating fluid from the isolated volume prior to the delivery of the therapeutic composition.
17 . The method of claim 16 further comprising a second step of aspirating the fluid from the isolated volume and delivering a second therapeutic composition.
18 . The method of claim 17 wherein the therapeutic composition and the second therapeutic composition are the same.
19 . The method of claim 16 wherein aspirating fluid results in reducing the volume of the aneurysm by at least about 10 percent.
20 . The method of claim 1 wherein the therapeutic composition acts on the wall of the vessel from about 5 minutes to about 30 minutes.