Fidgetin-like 2 as a target to enhance wound healing
View Patent ↗Methods of treating a wound in a subject are provided comprising administering to the subject an amount of an inhibitor of Fidgetin-like 2. Compositions and pharmaceutical compositions comprising an amount of an inhibitor of Fidgetin-like 2 are also provided. Methods are also provided for identifying an inhibitor of Fidgetin-like 2.
1. A method of reducing a scar comprising directly administering to the scar an amount of a siRNA or shRNA directed against a DNA or RNA encoding a human Fidgetin like-2 comprising the amino acid set forth in SEQ ID NO:2 effective to reduce a scar.
2. A method of stimulating neoangiogenesis in a tissue comprising directly administering to the tissue an amount of a siRNA or shRNA directed against a DNA or RNA encoding a human Fidgetin like-2 comprising the amino acid set forth in SEQ ID NO:2 effective to stimulate neoangiogenesis in a tissue.