Sustained delivery formulations of risperidone compounds
View Patent ↗The present invention relates to a risperidone sustained release delivery system for treatment of medical conditions relating delusional psychosis, schizophrenia, bipolar disorder, psychotic depression, obsessive-compulsion disorder, Tourette syndrome, and autistic spectrum disorders. The sustained release delivery system includes a flowable composition containing risperidone, a metabolite, or a prodrug thereof and an implant containing risperidone, a metabolite, or a prodrug thereof. The flowable composition may be injected into tissue whereupon it coagulates to become the solid or gel, monolithic implant. The flowable composition includes a biodegradable, thermoplastic polymer, an organic liquid, and risperidone, a metabolite, or a prodrug thereof.
1. A method for treating schizophrenia in a human in need thereof comprising administering a flowable composition to the human once per month by subcutaneous injection to treat the schizophrenia;
wherein the flowable composition comprises:
(a) about 15 wt % risperidone base in
(b) about 45 wt % of an 80/20 poly(DL-lactide-co-glycolide) biodegradable thermoplastic polyester with a terminal carboxy group having an average molecular weight of about 10,000 Daltons to about 50,000 Daltons; and
(c) about 55 wt % of N-methyl-2-pyrrolidone.
2. The method of claim 1 , wherein the flowable composition transforms into a solid implant in situ after subcutaneous injection.
3. The method of claim 1 , wherein the flowable composition produces maximum plasma concentration (C max ) levels of risperidone in the human within about 6 hours of subcutaneous injection.
4. The method of claim 1 , wherein the flowable composition produces maximum plasma concentration (C max ) levels of risperidone in the human within about 2 hours of subcutaneous injection.
5. The method of claim 1 , wherein the biodegradable thermoplastic polyester has an average molecular weight of about 15,000 Daltons to about 40,000 Daltons.
6. The method of claim 1 , wherein the biodegradable thermoplastic polyester has a polydispersity index of about 1.4 to about 2.0.
7. A method for treating a mental impairment in a human in need thereof comprising administering a flowable composition to the human once per month by subcutaneous injection to treat the mental impairment;
wherein the mental impairment is schizophrenia, bipolar disorder, psychotic depression, obsessive-compulsion disorder, Tourette's syndrome, or an autism spectrum disorder; and
wherein the flowable composition comprises:
(a) about 15 wt % risperidone base in
(b) about 45 wt % of an 80/20 poly(DL-lactide-co-glycolide) biodegradable thermoplastic polyester with a terminal carboxy group having an average molecular weight of about 10,000 Daltons to about 50,000 Daltons; and
(c) about 55 wt % of N-methyl-2-pyrrolidone.
8. The method of claim 7 , wherein the flowable composition transforms into a solid implant in situ after subcutaneous injection.
9. The method of claim 7 , wherein the flowable composition produces maximum plasma concentration (C max ) levels of risperidone in the human within about 6 hours of subcutaneous injection.
10. The method of claim 7 , wherein the flowable composition produces maximum plasma concentration (C max ) levels of risperidone in the human within about 2 hours of subcutaneous injection.
11. The method of claim 7 , wherein the biodegradable thermoplastic polyester has an average molecular weight of about 15,000 Daltons to about 40,000 Daltons.
12. The method of claim 7 , wherein the biodegradable thermoplastic polyester has a polydispersity index of about 1.4 to about 2.0.