Methods and compositions for treating prostate cancer or inducing a humoral immune response against prostate cancer
View Patent ↗The present invention relates to prostate cancer markers, compositions comprising such markers, and methods of using such markers to induce or increase an immune response against prostate cancer. An immune response against the markers correlates with an immune response, in particular a humoral immune response, against prostate cancer cells which immune response is preferably associated with prophylaxis of prostate cancer, treatment of prostate cancer, and/or amelioration of at least one symptom associated with prostate cancer.
1. An in vitro composition comprising one or more populations of cells genetically modified to express the coding sequence of granulocyte-macrophage colony stimulating factor (“GM-CSF”) and the coding sequence of one or more prostate tumor-associated antigens selected from the group consisting of HLA-A24, FLJ14668 (SEQ ID NO: 3), NNAT, SELS, HIGD2A, SSR3 and NRP2, wherein the genetically modified cells comprise prostate tumor cells, bystander cells, or both prostate tumor cells and bystander cells.
2. The composition of claim 1 , wherein the prostate tumor-associated antigen is FLJ14668 (SEQ ID NO.: 3).
3. The composition of claim 1 , wherein the one or more populations of cells genetically modified to express the coding sequence for GM-CSF and one or more prostate tumor-associated antigens selected from the group consisting of HLA-A24, FLJ14668 (SEQ ID NO.: 3), NNAT, SELS, HIGD2A, SSR3 and NRP2 is a single cell population.
4. The composition of claim 1 , wherein the one or more populations of cells genetically modified to express the coding sequence for GM-CSF and one or more prostate tumor-associated antigens selected from the group consisting of HLA-A24, FLJ14668 (SEQ ID NO.: 3), NNAT, SELS, HIGD2A, SSR3 and NRP2 comprises at least two distinct cell populations.
5. The composition of claim 1 , wherein the genetically modified cells are prostate tumor cells.
6. The composition of claim 1 , wherein the genetically modified cells are bystander cells.