NOVEL BIOLOGICAL IMPLANT COMPOSITIONS, IMPLANTS AND METHODS
The present application is directed to the field of implants comprising processed hard or soft biological tissues for use in implantation in humans. The molded biological tissue implants of the present application are preferably made from allograft soft tissue sources and demineralized bone matrix. The present application provides biological implants exhibiting advantageous properties of absorption, expansion, resiliency and shape retention. The properties of the biological implants produced by the methods of the present application are leveraged in the creation and development of novel biological implant constructs and of novel methods of treatment and surgical technique.
1 . A biological graft comprising;
a bone block of cortical bone, cancellous bone or both, said bone block having at least one porous or semi-porous surface; and
a molded tissue component comprising demineralized bone matrix (DBM) and a tissue slurry;
wherein said molded tissue component is integrated into said porous or semi-porous surface of said bone block.
2 . The graft of claim 1 , wherein said molded tissue component is frozen and lyophilized along at least a portion of at least one outer surface of said bone block.
3 . The graft of claim 1 , wherein said bone block further comprises at least one slot, groove or hole to increase penetration of said molded tissue component.
4 . The graft of claim 1 , wherein said molded tissue component covers at least two sides of said bone block and substantially fills a passageway between at least two of said at least two sides.
5 . The graft of claim 1 , wherein said bone block is in the shape of a wedge, trapezoid, plank or ring.
6 . The graft of claim 1 consisting essentially of human tissue components.
7 . The graft of claim 1 comprising xenograft tissue components.
8 . The graft of claim 1 , wherein said molded tissue component comprises least one layer which is osteoconductive, compressible, conformable, and hydratable.
9 . The graft of claim 1 , wherein said bone block is incorporated into an assembled graft comprising two or more bone blocks and said molded tissue component is sandwiched between at least two of the bone blocks.
10 . The graft of claim 1 further comprising a compression zone formed by the molded tissue component, outside of the bone block and adjacent to the surface.
11 . The graft of claim 10 , wherein said compression zone exhibits expansion upon hydration of the implant at a surgical site.