Topically administered strontium-containing complexes for treating pain, pruritis and inflammation
View Patent ↗The present disclosure consists of therapeutically-active compositions that combine strontium with at least one additional molecules that increase the overall therapeutic potency of the combination beyond the potency of any of the separate constituents. Specifically, the combinations described herein perform two important functions; (1) they increase the ability of topically-applied strontium to inhibit both acute sensory irritation (e.g., pruritus and pain), redness, swelling and inflammation (collectively defined for purposes of this description, “irritation”) and the chronic irritation that is characteristic of and contributes to the development and maintenance of painful or pruritic neuropathic conditions; and (2) they decrease the strontium activated pathways that are known to enhance the development and maintenance of pain, pruritis and neuropathic conditions.
1. A topical formulation comprising:
a complex of divalent cationic strontium, N-acetylcysteine or an ester thereof and at least one polyhydroxyphenol selected from the group consisting of gallic acid and caffeic acid, wherein the N-acetylcysteine or an ester thereof and the polyhydroxyphenol are conjugated together by a thioester bond formed by a sulfhydryl group of the N-acetylcysteine or an ester thereof and a carboxyl group of the polyhydroxyphenol moiety; and
a carrier vehicle.
2. The topical formulation according to claim 1 , further comprising a polymer.
3. The topical formulation of claim 1 , further comprising at least one aromatic amino acid selected from the group consisting of: histidine, tyrosine, phenylalanine and tryptophan.
4. The topical formulation of claim 3 , wherein the at least one aromatic amino acid is an L-isomer.
5. A method of treating acute pain or pruritis in a subject comprising administering the topical formulation of claim 1 to the subject.
6. A method of treating chronic pain or pruritis in a subject comprising administering the topical formulation of claim 1 to the subject.
7. A method of treating neuropathic pain or pruritis in a subject comprising administering the topical formulation of claim 1 to the subject.
8. The topical formulation of claim 2 , wherein the polymer is a neutral or anionic polymer.
9. The topical formulation of claim 8 , wherein, the neutral polymer is polyvinylpyrrolidone.
10. The topical formulation of claim 9 , wherein the polyvinylpyrrolidone is chemically modified by derivatization and/or crosslinking.
11. The topical formulation of claim 2 , wherein the polymer is capable of ionic association with the complex and facilitates controlled release of the divalent cationic strontium.
12. The topical formulation of claim 2 , wherein the polymer is capable of minimizing osmolarity.