Methods for iontophoretically treating nausea and migraine
View Patent ↗Methods for treating nausea and migraine by iontophoretically administering triptan compounds are provided.
1. A method for treating photophobia or phonophobia in a subject suffering from a migraine, the method comprising: iontophoretically administering an effective amount of a triptan compound to a subject suffering from a migraine, such that the photophobia or phonophobia is treated without cardiovascular side effects, wherein the triptan compound is administered iontophoretically in a two phase manner, comprising:
a first phase, wherein the triptan compound is administered with a current of about 4 mA for about an hour; and
a second phase, wherein the triptan compound is administered with a current of about 2 mA for about three hours.
2. The method of claim 1 , wherein the current does not substantially irritate the subject's skin.
3. The method of claim 2 , wherein the current does not result in a skin erythema score of greater than 2.5, of greater than 2.0, of greater than 1.5, or of greater than 1.0, immediately after patch removal.
4. The method of claim 1 , wherein the subject is a human.
5. The method of claim 1 , wherein the subject is suffering from a prodromal migraine symptom, and wherein the prodromal migraine symptom is treated.
6. The method of claim 1 , wherein the subject is suffering from a migraine aura, and wherein the migraine aura is treated.
7. The method of claim 1 , wherein the photophobia or phonophobia is treated without migraine-associated absorption reduction.
8. The method of claim 1 , wherein the migraine is aborted in the subject.
9. The method of claim 1 , wherein the photophobia or phonophobia is treated without triptan side effects.
10. The method of claim 1 , wherein the photophobia or phonophobia is treated for at least two hours.
11. The method of claim 1 , wherein the migraine is treated for at least two hours.
12. The method of claim 1 , wherein the subject is suffering from a migraine with a pain severity score of 2 or 3.
13. The method of claim 1 , wherein the triptan compound is a sumatriptan or a pharmaceutically acceptable salt thereof.
14. The method of claim 13 , wherein the subject's headache score is reduced from a score of about 3 to about 2, to about 1, or to about 0.
15. The method of claim 13 , wherein the subject's headache score is reduced from a score of about 2 to about 1, or to about 0.
16. The method of claim 13 , wherein iontophoretically administering the triptan compound comprises a current which results in minimal or no erythema.