Method of treating psoriasis using an IL-17 receptor antibody formulation

1. A method of treating psoriasis in a human patient in need thereof, comprising administering to the patient an effective amount of a formulation comprising an anti-IL-17RA antibody, or fragment thereof, that specifically binds the human IL-17 receptor A, wherein:

(a) the anti-IL-17RA antibody comprises a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO:5, a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO:7, a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:8, a light chain CDR1 comprising the amino acid sequence of SEQ ID NO:9, a light chain CDR2 comprising the amino acid sequence of SEQ ID NO: 10, and a light chain CDR3 comprising the amino acid sequence of SEQ ID NO: 11, and

(b) the formulation comprises (i) 30 mM glutamic acid, (ii) a pH of 4.8±0.2, (iii) 3±0.2% proline (w/v), (iv) 0.01±0.002% (w/v) polysorbate 20, and

(v) 210 mg of the anti-IL-17RA antibody, whereby the psoriasis is treated in the human patient.

2. The method of claim 1 , wherein the formulation is administered to the patient once a week, once every two weeks, or once every four weeks.

3. The method of claim 2 , wherein the formulation is administered to the patient over a period of one week to 24 weeks.

4. The method of claim 1 , wherein the formulation is administered to the patient subcutaneously, intradermally, intramuscularly, or intravenously.

5. The method of claim 1 , wherein the psoriasis is selected from the group consisting of:

a) plaque psoriasis;

b) moderate to severe plaque psoriasis;

c) chronic moderate to severe plaque psoriasis and said patients are candidates for systemic therapy or phototherapy; and

d) chronic moderate to severe plaque psoriasis and wherein said patients have failed to respond to, have a contraindication to, or are intolerant to other systemic therapies including cyclosporin, methotrexate, and psoralen plus ultraviolet-A phototherapy.