IP Library Granted Patent US 9,202,275
Granted Patent B2
US 9,202,275 · App. 14/500,434 · Granted Dec 1, 2015

Breast tomosynthesis with display of highlighted suspected calcifications

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Quick Facts
Patent No.
US 9,202,275
App. No.
14/500,434
Granted
Dec 1, 2015
Kind
B2
Abstract

Systems and methods that facilitate the presentation and assessment of selected features in projection and/or reconstructed breast images, such as calcifications that meet selected criteria of size, shape, presence in selected slice images, distribution of pixels that could be indicative of calcification relative to other pixels or of other image features of clinical interest.

Claims (63)

1. A method of acquiring and displaying breast tissue images, comprising:

acquiring x-ray image data of a patient's breast, the x-ray image data comprising projection images taken at different angles of an origin of imaging x-rays relative to the patient's breast;

generating tomosynthesis image data from the acquired x-ray image data, the tomosynthesis image data comprising a plurality of image slices of the patient's breast, each image slice having an orientation and a thickness;

identifying an image slice of interest in the tomosynthesis image data, the identified image slice of interest depicting an object of interest; and

displaying an image stack guide on a user interface, the image stack guide comprising

a linear display object having a plurality of marks, each mark of the plurality associated with a respective image slice of the plurality of image slices, such that a user can navigate through the plurality of image slices using the linear display object, and

an indicator disposed adjacent a respective mark on the linear display object associated with the identified image slice of interest.

2. The method of claim 1 , further comprising

receiving a user input through an input device operatively coupled to the user interface, the input comprising one of

navigating to the identified image slice of interest,

selecting the indicator in the displayed image stack guide, and

selecting a mark associated with the identified image slice of interest; and

displaying the identified image slice of interest on the user interface in response to the received user input.

3. The method of claim 1 , wherein the plurality of marks are disposed sequentially along a longitudinal axis of the linear display object.

4. The method of claim 2 , the plurality of marks including a plurality of large marks, wherein respective adjacent large marks of the plurality are separated from each other by one or more small marks.

5. The method of claim 3 , wherein the plurality of marks comprises

a first large mark separated from a second large mark by a first number of small marks, and

a third large mark separated from a fourth large mark by a second number of small marks, wherein the first and second numbers are different.

6. The method of claim 1 , further comprising displaying an image slice of the plurality of image slices on the user interface,

wherein, when the image slice is displayed on the user interface, the image stack guide comprises a pointer disposed adjacent a respective mark on the linear display object associated with the displayed image slice.

7. The method of claim 5 , the pointer comprising a geometric feature surrounding or otherwise highlighting and/or indicating the second mark.

8. The method of claim 1 ,

wherein identifying an image slice of interest in the tomosynthesis image data comprises identifying a plurality of image slices of interest in the tomosynthesis image data, and

wherein the image stack guide comprises a plurality of indicators disposed adjacent respective marks on the linear display object.

9. The method of claim 7 , further comprising

receiving a first input through an input device operatively coupled to the user interface;

displaying a first one of the plurality of identified image slices of interest on the user interface in response to the received first input;

receiving a second input through the input device; and

displaying a second one of the plurality of identified image slices of interest on the user interface in response to the received second input.

10. A system for acquiring and displaying breast tissue images, comprising:

an x-ray data acquisition unit configured for acquiring x-ray image data of a patient's breast, the x-ray image data comprising projection images taken at different angles of an origin of imaging x-rays relative to the patient's breast;

an image processing unit operatively associated with the x-ray data acquisition unit; and

a user interface operatively associated with the image processing unit,

wherein the image processing unit is configured to:

generate tomosynthesis image data from the acquired x-ray image data, the tomosynthesis image data comprising a plurality of image slices of the patient's breast, each image slice having an orientation and a thickness;

identify an image slice of interest in the tomosynthesis image data, the identified image slice of interest depicting an object of interest; and

display an image stack guide on the user interface, the image stack guide comprising

a linear display object having a plurality of marks, each mark of the plurality associated with a respective image slice of the plurality of image slices, such that a user can navigate through the plurality of image slices using the linear display object, and

an indicator disposed adjacent a respective mark on the linear display object associated with the identified image slice of interest.

11. The system of claim 10 , further comprising an input device operatively coupled to the image processing unit and the user interface,

wherein the image processing unit is further configured to:

receive a user input through the input device, the input comprising one of

navigating to the identified image slice of interest,

selecting the indicator in the displayed image stack guide, and

selecting a mark associated with the identified image slice of interest; and

display the identified image slice of interest on the user interface in response to the received user input.

12. The system of claim 10 , wherein the plurality of marks are disposed sequentially along a longitudinal axis of the linear display object.

13. The system of claim 12 , the plurality of marks including a plurality of large marks, wherein respective adjacent large marks of the plurality are separated from each other by one or more small marks.

14. The system of claim 13 , wherein the plurality of marks comprises

a first large mark separated from a second large mark by a first number of small marks, and

a third large mark separated from a fourth large mark by a second number of small marks, wherein the first and second numbers are different.

15. The system of claim 10 , wherein the image processing unit is further configured to display an image slice of the plurality of image slices on the user interface,

wherein, when the image slice is displayed on the user interface, the image stack guide comprises a pointer disposed adjacent a respective mark on the linear display object associated with the displayed image slice.

16. The system of claim 15 , the pointer comprising a geometric feature surrounding or otherwise highlighting and/or indicating the second mark.

17. The system of claim 10 ,

wherein the image processing unit is further configured to identify a plurality of image slices of interest in the tomosynthesis image data, and

wherein the image stack guide comprises a plurality of indicators disposed adjacent respective marks on the linear display object.

18. The system of claim 17 , further comprising an input device operatively coupled to the image processing unit and the user interface,

wherein the image processing unit is further configured to:

receive a first input through the input device;

displaying a first one of the plurality of identified image slices of interest on the user interface in response to the received first input;

receiving a second input through the input device; and

displaying a second one of the plurality of identified image slices of interest on the user interface in response to the received second input.

Assignments (5)
RELEASE OF SECURITY INTEREST Recorded Apr 28, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC., ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO DIRECT RADIOGRAPHY CORP.; CYTYC CORPORATION, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO BIOLUCENT, LLC; CYTYC SURGICAL PRODUCTS, LLC, AS SUCCESSOR-BY-CONVERSION TO CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; GEN-PROBE INCORPORATED, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.
Reel/Frame 075566/0039 →
SECURITY INTEREST Recorded Apr 8, 2026
From: BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; CYTYC CORPORATION; SUROS SURGICAL SYSTEMS, INC.; GYNESONICS, INC.; BOLDER SURGICAL, LLC; FAXITRON BIOPTICS, LLC; HEALTH BEACONS, INC.; HOLOGIC, INC.
To: ROYAL BANK OF CANADA, AS COLLATERAL AGENT
Reel/Frame 075462/0440 →
SECURITY AGREEMENT Recorded Aug 7, 2015
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 036307/0199 →
SECURITY INTEREST RELEASE R/F 034289 0249 Recorded Jul 17, 2015
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 036127/0185 →
SECURITY INTEREST Recorded Dec 1, 2014
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 034289/0249 →