Pixel array medical devices and methods
Systems, instruments or devices, and methods or procedures are described in which a scalpet array is applied to a target site with the use of a pattern. The scalpet array comprises scalpets positioned on a device. Skin pixels are incised at the target site via application of a load through the scalpet array. A recipient site is prepared by positioning the pattern at the recipient site and applying the scalpet array to generate skin defects. The incised skin pixels are applied at the skin defects of the recipient site.
1. A system comprising:
a guide plate comprising perforations arranged in a configuration corresponding to a harvest pattern, and configured to be positioned at a donor site and a recipient site;
a device comprising a scalpet array that includes at least one scalpet, wherein the at least one scalpet is configured to align with the harvest pattern, wherein the at least one scalpet is configured to incise skin pixels at the donor site and generate skin defects at the recipient site; and
an adherent substrate configured to capture the incised skin pixels at the donor site.
2. The system of claim 1 , wherein the guide plate is configured for use in marking the harvest pattern on a skin surface on at least one of the donor site and the recipient site.
3. The system of claim 2 , wherein the harvest pattern comprises an indicator on a skin surface on at least one of the donor site and the recipient site.
4. The system of claim 1 , wherein the scalpet array is removeably coupled to the device.
5. The system of claim 1 , wherein the scalpet array is disposable.
6. The system of claim 1 , wherein a shape of each scalpet of the scalpet array is elliptical.
7. The system of claim 1 , wherein a shape of each scalpet of the scalpet array is circular.
8. The system of claim 1 , wherein a shape of each scalpet of the scalpet array is semicircular.
9. The system of claim 1 , wherein a shape of each scalpet of the scalpet array is one of square, rectangular, and flat.
10. The system of claim 1 , wherein each scalpet of the at least one scalpet includes a beveled surface.
11. The system of claim 1 , wherein each scalpet of the plurality of scalpets includes at least one pointed surface.
12. The system of claim 1 , wherein each scalpet of the plurality of scalpets includes at least one needle.
13. The system of claim 12 , wherein the at least one needle comprises at least one needle including multiple points.
14. The system of claim 1 , wherein the scalpet array generates the incised skin pixels using at least one of piercing force, impact force, rotational force, and vibration.
15. The system of claim 1 , wherein at least one scalpet of the scalpet array comprises a through orifice.
16. The system of claim 1 , wherein at least one diametric dimension of each scalpet of the scalpet array is approximately in a range 0.5 millimeters to 4.0 millimeters.
17. The system of claim 1 , wherein the adherent substrate comprises a flexible substrate.
18. The system of claim 1 , wherein the adherent substrate comprises a semi-porous membrane.
19. The system of claim 1 , wherein the at least one scalpet on the device is arranged corresponding to the harvest pattern.
20. The system of claim 19 , wherein the at least one scalpet on the device is configured to align with the harvest pattern.
21. The system of claim 20 , wherein the scalpet array is applied to the donor site directly in accordance with the harvest pattern and the skin pixels are incised.
22. The system of claim 21 , wherein the adherent substrate is configured to maintain the incised skin pixels in accordance with the harvest pattern during transfer and application of the incised skin pixels at the recipient site.
23. The system of claim 20 , wherein the scalpet array is applied to the recipient site directly in accordance with the harvest pattern and the skin defects are generated.
24. The system of claim 23 , wherein the skin defects are generated according to the harvest pattern.
25. The system of claim 19 , wherein the adherent substrate is configured for application to the target site subsequent to application of the scalpet array.
26. The system of claim 25 , wherein the guide plate is positioned directly on a skin surface at one of the donor site and the recipient site.
27. The system of claim 25 , wherein the guide plate is configured to extrude the incised skin pixels.
28. The system of claim 27 , wherein the skin pixels are extruded through the perforations in response to an applied load.
29. The system of claim 27 , wherein the skin pixels are extruded through the incised skin surface in response to an applied load.
30. The system of claim 25 , wherein the incised skin pixels of the donor site and the skin defects of the recipient site are arranged in the configuration.
31. The system of claim 25 , wherein the incised skin pixels of the donor site comprise a first configuration and the skin defects of the recipient site comprise a second configuration, wherein the first configuration and the second configuration are different.
32. The system of claim 25 , wherein the at least one scalpet on the device is configured to align with at least one set of the perforations of the guide plate.
33. The system of claim 25 , wherein the scalpet array is applied to the donor site directly through the at least one set of the perforations and the skin pixels are incised.
34. The system of claim 33 , wherein the adherent substrate is configured to maintain relative positioning of the incised skin pixels in the configuration during transfer to the recipient site and application of the incised skin pixels at the recipient site.
35. The system of claim 25 , wherein the scalpet array is applied to the recipient site directly through the at least one set of the perforations and the skin defects are generated.
36. The system of claim 35 , wherein the skin defects are generated according to the configuration.
37. The system of claim 25 , wherein the guide plate is at least one of adherent, rigid, semi-rigid, conformable, non-conformable, and non-deformable.
38. The system of claim 25 , wherein the guide plate includes at least one of metal, plastic, polymer, and membranous material.
39. The system of claim 25 , wherein the guide plate is configured to transmit a load to a skin surface of at least one of the donor site and the recipient site.
40. The system of claim 1 , wherein the scalpet array is configured to transfer a load to subjacent skin surface that includes the donor site, wherein the skin pixels are circumferentially incised by application of the load.
41. The system of claim 1 , comprising a cutting member.
42. The system of claim 41 , wherein the incised skin pixels are extruded, wherein the extruded skin pixels are transected by the cutting member.
43. The system of claim 42 , wherein the adherent substrate is pulled away from the donor site, and bases of the incised skin pixels are transected by the cutting member.
44. The system of claim 41 , wherein the cutting member is coupled to a plate frame.
45. The system of claim 44 , wherein the plate frame is coupled to a guide plate.
46. The system of claim 44 , wherein the adherent substrate is coupled to at least one of the guide plate and the plate frame.
47. The system of claim 1 , wherein the incised skin pixels are applied directly from the adherent substrate to the skin defects at the recipient site.
48. The system of claim 47 , wherein the incised skin pixels are aligned with the skin defects at the recipient site.
49. The system of claim 48 , wherein each incised skin pixel is inserted into a corresponding skin defect at the recipient site.
50. The system of claim 1 , comprising applying a first bandage to the donor site following the incising of the skin pixels, wherein the first bandage closes the donor site and controls a direction that the skin defects of the donor site are closed.
51. The system of claim 1 , comprising applying a second bandage to the recipient site following the applying of the incised skin pixels at the recipient site, wherein the second bandage generates a force at the recipient site.
52. The system of claim 1 , wherein the incised skin pixels include hair follicles.
53. The system of claim 1 , wherein the skin defects are configured to evoke neovascularization in the incised skin pixels inserted at the recipient site.
54. The system of claim 1 , wherein the skin defects are configured to evoke a wound healing response in the incised skin pixels inserted at the recipient site.
55. A system comprising:
a guide plate configured for use in generating a harvest pattern including indicators arranged in a configuration, wherein the harvest pattern is configured to be positioned at a target site and a recipient site;
a device comprising a scalpet array that includes a plurality of scalpets arranged in the configuration, wherein the plurality of scalpets is configured to align with at least one set of the indicators, wherein the plurality of scalpets is configured to incise skin pixels at the target site and generate skin defects at the recipient site; and
an adherent substrate configured to capture the incised skin pixels at the target site and maintain the configuration during application of the incised skin pixels at the recipient site.
56. A system comprising:
a guide plate configured for use in generating a harvest pattern including indicators arranged in a configuration, wherein the harvest pattern is configured to be positioned at a target site and a recipient site; and
a device comprising a scalpet array that includes a plurality of scalpets arranged in the configuration, wherein the plurality of scalpets is configured to align with at least one set of the indicators, wherein the plurality of scalpets is configured to incise skin pixels at the target site and generate skin defects at the recipient site.