Synthesizing complex population selection criteria
System and method to determine a reduced cohort criteria, the method including: defining N selection criteria to select a cohort from among a universe of patient data; querying a patient database, by use of a processor, and by use of the N selection criteria, in order to define a full patient population; selecting a subset of size M of the N selection criteria, to produce a subset criteria; selecting a permutation of the subset criteria, to produce a permuted subset criteria in a predetermined order; for each member of the permuted subset criteria: querying the patient database by use of the member of the permuted subset criteria to produce a respective interim patient population; combining all respective interim patient populations to produce a partial patient population; and calculating, by a processor, a coverage figure of merit that compares the partial patient population to the full patient population.
1. A machine-implemented method to select a subset of selection criteria with which to identify a population for membership in a study cohort, comprising:
identifying a full population of patients having characteristics that satisfy N selection criteria, wherein N is an integer greater than 29;
defining all possible subsets of the N selection criteria;
identifying all possible permutations of each of the subsets of the selection criteria, wherein the permutations include re-orderings of the selection criteria of the respective subsets of the selection criteria;
determining, for each permutation of each subset, a partial population of patients having characteristics that satisfy the ordering of the subset of the selection criteria of the permutation;
recording each partial population that matches the identified full population to within a predetermined threshold, including recording the subset of selection criteria, the ordering of the subset of selection criteria, and a relative significance of each criterion of the subset of the selection criteria;
selecting one or more of the recorded partial populations that have a fewest number of the selection criteria; and
graphically displaying each selected partial population, the corresponding subset of selection criteria, and the relative significance of each criterion of the subset of selection criteria.
2. The method of claim 1 , further comprising omitting a portion of the selection criteria for membership in the study cohort.
3. The method of claim 1 , further comprising:
incrementing a number of the selection criteria per subset from M=1 towards M=N−1; and
performing the defining, the identifying, the determining, and the recording for each of multiple values of M.
4. The method of claim 1 , further comprising:
decrementing a number of the selection criteria per subset from M=N−1 towards M=1; and
performing the defining, the identifying, the calculating, and the recording for each of multiple values of M.
5. An apparatus to select a subset of selection criteria with which to identify a population for membership in a study cohort, comprising a processor configured to:
identify a full population of patients having characteristics that satisfy N selection criteria, wherein N is an integer greater than 29;
define all possible subsets of the N selection criteria;
identify all possible permutations of each of the subsets of the selection criteria, wherein the permutations include re-orderings of the selection criteria of the respective subsets of the selection criteria;
determine, for each permutation of each subset, a partial population of patients having characteristics that satisfy the ordering of the subset of the selection criteria of the permutation;
record each partial population that matches the identified full population to within a predetermined threshold, including to record the subset of selection criteria, the ordering of the subset of selection criteria, and a relative significance of each criterion of the subset of the selection criteria;
select one or more of the recorded partial populations that have a fewest number of the selection criteria; and
graphically display each selected partial population, the corresponding subset of selection criteria, and the relative significance of each criterion of the subset of selection criteria.
6. The apparatus of claim 5 , wherein the processor is further configured to:
omit a portion of the selection criteria for membership in the study cohort.
7. The apparatus of claim 5 , wherein the processor is further configured to:
increment a number of the selection criteria per subset from M=1 towards M=N−1; and
perform the defining, the identifying, the determining, and the recording for each of multiple values of M.
8. The apparatus of claim 5 , wherein the processor is further configured to:
decrement a number of the selection criteria per subset from M=N−1 towards M=1; and
perform the defining, the identifying, the calculating, and the recording for each of multiple values of M.
9. A non-transitory computer readable medium encoded with a computer program that comprises instructions to cause a processor to:
identify a full population of patients having characteristics that satisfy N selection criteria, wherein N is an integer greater than 29;
define all possible subsets of the N selection criteria;
identify all possible permutations of each of the subsets of the selection criteria, wherein the permutations include re-orderings of the selection criteria of the respective subsets of the selection criteria;
determine, for each permutation of each subset, a partial population of patients having characteristics that satisfy the ordering of the subset of the selection criteria of the permutation;
record each partial population that matches the identified full population to within a predetermined threshold, including to record the subset of selection criteria, the ordering of the subset of selection criteria, and a relative significance of each criterion of the subset of the selection criteria;
select one or more of the recorded partial populations that have a fewest number of the selection criteria; and
graphically display each selected partial population, the corresponding subset of selection criteria, and the relative significance of each criterion of the subset of selection criteria.
10. The non-transitory computer readable medium of claim 9 , further comprising instructions to cause the processor to:
omit a portion of the selection criteria for membership in the study cohort.
11. The non-transitory computer readable medium of claim 9 , further comprising instructions to cause the processor to:
increment a number of the selection criteria per subset from M=1 towards M=N−1; and
perform the defining, the identifying, the determining, and the recording for each of multiple values of M.
12. The non-transitory computer readable medium of claim 9 , further comprising instructions to cause the processor to:
decrement a number of the selection criteria per subset from M=N−1 towards M=1; and
perform the defining, the identifying, the calculating, and the recording for each of multiple values of M.