Actinium-225 compositions of matter and methods of their use

1. An actinium-225 composition, comprising the following quotient of activity quantity ratios:

actinium-226/actinium-225 less than 25;

actinium-227/actinium-225 less than 0.02;

cerium-139/actinium-225 less than 0.1;

cerium-141/actinium-225 less than 20;

cerium-143/actinium-225 less than 70; and

lanthanum-140/actinium-225 less than 20

wherein the quotient of activity quantity ratios are measured at the end of bombardment.

2. The actinium-225 composition of claim 1 , wherein the quotient of activity quantity ratios are:

actinium-226/actinium-225 between 0.2 and 25;

actinium-227/actinium-225 between 0.0001 and 0.02;

cerium-139/actinium-225 between 0.001 and 0.1;

cerium-141/actinium-225 between 0.03 and 20;

cerium-143/actinium-225 between 0.1 and 70; and

lanthanum-140/actinium-225 between 0.03 and 20.

3. The actinium-225 composition of claim 1 , wherein the quotient of activity quantity ratios are:

actinium-226/actinium-225 less than 8;

actinium-227/actinium-225 less than 0.01;

cerium-139/actinium-225 less than 0.05;

cerium-141/actinium-225 less than 6;

cerium-143/actinium-225 less than 20; and

lanthanum-140/actinium-225 less than 6.

4. The actinium-225 composition of claim 1 , wherein the quotient of activity quantity ratios are:

actinium-226/actinium-225 between 0.64 and 8;

actinium-227/actinium-225 between 0.0005 and 0.01;

cerium-139/actinium-225 between 0.005 and 0.05;

cerium-141/actinium-225 between 0.1 and 6;

cerium-143/actinium-225 between 0.3 and 20; and

lanthanum-140/actinium-225 between 0.1 and 6.

5. An actinium-225 composition comprising the following quotient of activity quantity ratios:

actinium-226/actinium-225 less than 1;

actinium-227/actinium-225 less than 0.03;

cerium-139/actinium-225 less than 0.3;

cerium-141/actinium-225 less than 30;

cerium-143/actinium-225 less than 1; and

lanthanum-140/actinium-225 less than 1.

6. The actinium-225 composition of claim 5 , wherein the quotient of activity quantity ratios are:

actinium-226/actinium-225 less than 0.05;

actinium-227/actinium-225 less than 0.01;

cerium-139/actinium-225 less than 0.01;

cerium-141/actinium-225 less than 10;

cerium-143/actinium-225 less than 0.3; and

lanthanum-140/actinium-225 less than 0.3.

7. The actinium-225 composition of claim 5 , wherein the quotient of activity quantity ratios are:

actinium-226/actinium-225 between 0.001 and 10; and

actinium-227/actinium-225 between 0.0003 and 0.03.

8. The actinium-225 composition of claim 5 , wherein the quotient of activity quantity ratios are:

actinium-226/actinium-225 between 0.005 and 0.05; and

actinium-227/actinium-225 between 0.001 and 0.01.

9. A pharmaceutical composition comprising the actinium-225 composition of claim 5 and a pharmaceutically acceptable carrier.

10. The pharmaceutical composition of claim 9 , wherein the actinium-225 is conjugated to an antibody.

11. A method of treating cancer in a patient comprising administering to the patient the pharmaceutical composition of claim 9 .

12. The method of claim 11 , wherein the cancer is breast cancer, a leukemia, a lymphoma, brain cancer, liver cancer, lung cancer, melanoma, ovarian cancer, prostate cancer, pancreatic cancer, or bone cancer.