Lipid compositions
View Patent ↗Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is Also disclosed are methods of producing the cationic lipid of formula (I).
1. A composition, the composition comprising a sterol; a neutral lipid; a PEG or a PEG-modified lipid; and a lipid of formula (III), (IV) or a mixture thereof,
wherein,
each R is independently
R 1 is H;
R 2 , for each occurrence, is independently, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, or heteroalkynyl; each of which is optionally substituted with one or more substituent; and
Y is O.
2. The composition of claim 1 , wherein R, for at least 3 occurrences, is
3. The composition of claim 1 , wherein R 2 is alkyl, alkenyl, or alkynyl.
4. The composition of claim 1 , wherein R for at least 3 occurrences is
5. The composition of claim 1 , comprising a compound of formula (V)
6. The composition of claim 1 , comprising a compound of formula (VI)
7. The composition of claim 1 , wherein the sterol is cholesterol.
8. The composition of claim 1 , wherein the composition comprises about 50% of the compound of formula (III), or (IV), or mixture thereof, about 38.5% of the sterol, and about 1.5% of the PEG or PEG-modified lipid, and about 10% of the neutral lipid.
9. The composition of claim 1 , further comprising a targeting lipid comprising N-acetyl galactosamine as a targeting moiety.
10. The composition of claim 1 , wherein the composition is an association complex.
11. The composition of claim 1 , wherein the composition is a liposome.
12. The composition of claim 1 , further comprising a nucleic acid agent.
13. The composition of claim 1 , further comprising at least one apolipoprotein.