IP Library › Granted Patent US 9,480,677
Granted Patent B2
US 9,480,677 · App. 14/510,634 · Granted Nov 1, 2016

Enantiomers of spiro-oxindole compounds and their uses as therapeutic agents

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Quick Facts
Patent No.
US 9,480,677
App. No.
14/510,634
Granted
Nov 1, 2016
Kind
B2
Abstract

This invention is directed to the (S)-enantiomer of the compound of formula (I): or a pharmaceutically acceptable solvate or prodrug thereof. This (S)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels.

Claims (2)

1. A method of treating familial erythromelalgia and primary erythromelalgia in a mammal by the inhibition of ion flux through a voltage-gated sodium channel in the mammal, wherein the method comprises administering to the mammal in need thereof a therapeutically effective amount of the (S)-enantiomer of 1′-{[5-(trifluoromethyl)furan-2-yl]methyl}spiro[furo[2,3-f][1,3]benzodioxole-7,3′-indol]-2′(1′H)-one having the following formula (I-S):

or a pharmaceutically acceptable solvate or prodrug thereof.

Assignments (7)
RELEASE OF SECURITY INTEREST Recorded Dec 5, 2025
From: JPMORGAN CHASE BANK, N.A.
To: PACIRA CRYOTECH, INC.; PACIRA PHARMACEUTICALS, INC.; PACIRA THERAPEUTICS, INC. (F/K/A FLEXION THERAPEUTICS, INC.)
Reel/Frame 073779/0532 →
TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENTS Recorded Mar 31, 2023
From: JPMORGAN CHASE BANK, N.A.
To: PACIRA CRYOTECH, INC.; PACIRA PHARMACEUTICALS, INC.; PACIRA THERAPEUTICS, INC. (F/K/A FLEXION THERAPEUTICS, INC.)
Reel/Frame 063213/0864 →
CONFIRMATORY GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS Recorded Mar 31, 2023
From: PACIRA CRYOTECH, INC.; PACIRA PHARMACEUTICALS, INC.; PACIRA THERAPEUTICS, INC. (F/K/A FLEXION THERAPEUTICS, INC.)
To: JPMORGAN CHASE BANK, N.A.
Reel/Frame 063214/0108 →
CHANGE OF NAME Recorded Feb 3, 2022
From: FLEXION THERAPEUTICS, INC.
To: PACIRA THERAPEUTICS, INC.
Reel/Frame 058945/0954 →
SUPPLEMENTAL CONFIRMATORY GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS Recorded Dec 14, 2021
From: PACIRA CRYOTECH, INC.; PACIRA PHARMACEUTICALS, INC.; FLEXION THERAPEUTICS, INC.
To: JPMORGAN CHASE BANK, N.A.
Reel/Frame 058516/0636 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 16, 2020
From: XENON PHARMACEUTICALS INC.
To: FLEXION THERAPEUTICS, INC.
Reel/Frame 051537/0223 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 17, 2014
From: CHAFEEV, MIKHAIL; FU, JIANMIN; CADIEUX, JEAN-JACQUES
To: XENON PHARMACEUTICALS INC.
Reel/Frame 033974/0174 →