IP Library Granted Patent US 9,187,495
Granted Patent B2
US 9,187,495 · App. 14/515,684 · Granted Nov 17, 2015

Compounds and methods for treating bacterial infections

Inventors: Gregory Steven Basarab (Waltham, MA); Madhusudhan Reddy Gowravaram (Waltham, MA); Sheila Irene Hauck (Waltham, MA); Fei Zhou (Waltham, MA)
Assignee: Entasis Therapeutics Limited
C07D498/22
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Quick Facts
Patent No.
US 9,187,495
App. No.
14/515,684
Granted
Nov 17, 2015
Kind
B2
Abstract

Compounds of formula (I), pharmaceutically acceptable salts thereof, and uses of the compounds of formula (I) for treating bacterial infections are disclosed.

Claims (5)

1. A compound represented by the following structural formula:

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient or diluent.

3. A method for treating a bacterial infection in a subject in need thereof comprising administering to the subject an effective amount of a compound as claimed in claim 1 , or a pharmaceutically acceptable salt thereof.

4. A method for inhibiting bacterial DNA gyrase in a subject in need thereof, comprising administering to the subject an effective amount of a compound as claimed in claim 1 , or a pharmaceutically acceptable salt thereof.

Assignments (5)
NUNC PRO TUNC ASSIGNMENT Recorded Feb 20, 2025
From: ENTASIS THERAPEUTICS LIMITED
To: ENTASIS THERAPEUTICS INC.
Reel/Frame 070271/0396 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 5, 2015
From: ASTRAZENECA AB
To: ENTASIS THERAPEUTICS LIMITED
Reel/Frame 036258/0232 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 20, 2014
From: BASARAB, GREGORY STEVEN; ZHOU, FEI; GOWRAVARAM, MADHUSUDHAN REDDY; HAUCK, SHEILA IRENE
To: ASTRAZENECA PHARMACEUTICALS LP
Reel/Frame 034215/0755 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 20, 2014
From: ASTRAZENECA PHARMACEUTICALS LP
To: ASTRAZENECA UK LIMITED
Reel/Frame 034215/0792 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 20, 2014
From: ASTRAZENECA UK LIMITED
To: ASTRAZENECA AB
Reel/Frame 034215/0853 →
Continuity (4)
Continuation 14159773 · Jan 21, 2014
Provisional Application 61859910 · Jul 30, 2013
Provisional Application 61755537 · Jan 23, 2013
Related Publication 20150203513A1 · Jul 23, 2015