System and method for neuromodulation
A method of treating autonomic imbalance in a patient includes energizing a first therapeutic element disposed to deliver therapy to a parasympathetic nerve fiber (e.g. vagus nerve), and energizing a second therapeutic element to deliver therapy to a sympathetic cardiac nerve fiber. At least one of the therapeutic elements is disposed in the vasculature superior to the heart. The therapy decreases the patient's heart rate and elevates or maintains the blood pressure of the patient.
1. A method of treating autonomic imbalance in a patient having a heart rate and a blood pressure, comprising:
delivering neuromodulation therapy to sustain or increase the blood pressure while decreasing the heart rate, said neuromodulating therapy including
(a) stimulating at least one extravascular parasympathetic nerve fiber using at least one first intravascularly-positioned electrode; and
(b) stimulating at least one extravascular cardiac sympathetic nerve fiber using at least one second intravascularly-positioned electrode,
wherein said method includes placing the second electrode in a posterior portion of a blood vessel.
2. The method of claim 1 , further including introducing a therapy device into the vasculature, the therapy device having the first and second electrodes thereon, and advancing the therapy device within the vasculature to position the first and second electrodes within the vasculature.
3. The method of claim 1 , wherein at least one of the first and second electrodes is disposed in venous vasculature superior to the heart.
4. The method of claim 3 , wherein at least one of the first and second electrodes is disposed in the superior vena cava.
5. The method of claim 1 , wherein steps (a) and (b) are performed simultaneously.
6. The method of claim 1 wherein steps (a) and (b) are performed at separate times.
7. The method of claim 1 , wherein the at least one parasympathetic nerve fiber is a vagus nerve fiber.
8. The method of claim 1 , wherein the at least one sympathetic nerve fiber is a sympathetic cardiac nerve fiber.
9. The method of claim 1 , wherein the method includes positioning the first and second electrodes in a segment of the superior vena cava extending between a right atrium and a junction of brachiocephalic veins.
10. The method of claim 1 , further including energizing the first and second electrodes using a stimulator disposed external to the patient.
11. The method of claim 1 , further including monitoring blood pressure and heart rate of the patient, and modifying stimulus from the first and second electrodes in response to detected changes in heart rate and/or blood pressure.
12. The method of claim 1 further including independently controlling stimulation of the sympathetic and parasympathetic nerve fibers.
13. The method of claim 1 , wherein step (b) is performed with the second electrode in said posterior position.