Hypertension therapy implant apparatus
An implant unit according to some embodiments may include a flexible carrier, at least one pair of modulation electrodes on the flexible carrier, and at least one implantable circuit in electrical communication with the at least one pair of modulation electrodes. The at least one pair of modulation electrodes and the at least one circuit may be configured for implantation through derma on an underside of a subject's chin and for location proximate to terminal fibers of the medial branch of the subject's hypoglossal nerve, such that an electric field extending from the at least one pair of modulation electrodes can modulate one or more of the terminal fibers of the medial branch of the hypoglossal nerve.
1. A hypertension therapy implant unit for affecting blood pressure, the implant unit comprising:
a flexible carrier;
at least one pair of modulation electrodes on the flexible carrier; and
at least one implantable circuit in electrical communication with the at least one pair of modulation electrodes, wherein the at least one pair of modulation electrodes and the at least one circuit are configured for intravascular implantation in a subject in a location proximal to at least one of a carotid baroreceptor or a glossopharyngeal nerve,
wherein the implantable circuit and the at least one pair of modulation electrodes are configured to cooperate to generate an electric field to cause modulation of at least a portion of the at least one of the carotid baroreceptor or the glossopharyngeal nerve.
2. The hypertension therapy implant unit of claim 1 , wherein the at least one pair of modulation electrodes and the at least one implantable circuit are configured for implantation in a jugular vein proximal to the glossopharyngeal nerve of the subject.
3. The hypertension therapy implant unit of claim 1 , wherein the at least one pair of modulation electrodes and the at least one implantable circuit are configured for implantation in a jugular vein proximal to the carotid baroreceptor of the subject.
4. The hypertension therapy implant unit of claim 1 , wherein the at least one pair of modulation electrodes and the at least one implantable circuit are configured for implantation in a carotid artery proximal to the carotid baroreceptor of the subject.
5. The hypertension therapy implant unit of claim 1 , wherein the at least one pair of modulation electrodes and the at least one implantable circuit are configured for implantation in a carotid artery proximal to the glossopharyngeal nerve of the subject.
6. The hypertension therapy implant unit of claim 1 , wherein the at least one pair of modulation electrodes are configured to be spaced apart from each other along a longitudinal direction of at least a portion of the at least one of the carotid baroreceptor or the glossopharyngeal nerve.
7. The hypertension therapy implant unit of claim 1 , wherein the implantable circuit and the at least one pair of modulation electrodes are configured to cooperate to generate an electric field to cause modulation of the at least a portion of the at least one of the carotid baroreceptor or the glossopharyngeal nerve through intervening tissue.
8. A hypertension therapy implant unit for affecting blood pressure, the implant unit comprising:
a flexible carrier;
at least one pair of modulation electrodes on the flexible carrier;
an antenna on the flexible carrier; and
at least one implantable circuit in electrical communication with the at least one pair of modulation electrodes, wherein the at least one pair of modulation electrodes and the at least one circuit are configured for intravascular implantation in a subject in a location proximal to a renal nerve,
wherein the implantable circuit is configured to electromagnetically couple with the antenna; and
wherein the implantable circuit and the at least one pair of modulation electrodes are configured to cooperate to generate an electric field to cause modulation of at least a portion of the renal nerve based on a degree of coupling between the implantable circuit and the antenna.
9. The hypertension therapy implant unit of claim 8 , wherein the at least one pair of modulation electrodes and the at least one implantable circuit are configured for implantation in the renal nerve that is proximal to a renal artery of the subject.