IP Library Granted Patent US 9,480,842
Granted Patent B2
US 9,480,842 · App. 14/525,134 · Granted Nov 1, 2016

Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods

Inventors: Konstantinos Alataris (Belmont, CA); Andre B. Walker (Monte Sereno, CA); Jon Parker (San Jose, CA); Yougandh Chitre (Santa Clara, CA); Sangsoo Wesley Park (San Jose, CA); James R. Thacker (Homer, AK)
Assignee: Nevro Corporation
A61N1/36171A61N1/0551A61N1/0553A61N1/06A61N1/36021A61N1/36071A61N1/36157A61N1/36164A61N1/36175A61N1/36182A61N1/3787A61N1/37235A61N1/37247A61N1/37264A61N1/3605
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Quick Facts
Patent No.
US 9,480,842
App. No.
14/525,134
Granted
Nov 1, 2016
Kind
B2
Abstract

A spinal cord modulation system is disclosed. While in one embodiment the system is used for the treatment of pain, other embodiments are also provided. In particular embodiments, the spinal cord modulation system generates and delivers an electrical therapy signal at a frequency of 10 kHz to address pain without creating unwanted sensory and/or motor side effects. The system may further include various signal delivery devices to deliver the therapy signal to a patient's spinal cord region.

Claims (41)

1. A spinal cord modulation system, comprising:

a signal generator configured to generate a therapy signal having a frequency of 10 kHz, an amplitude up to 6 mA, and pulses having a pulse width between 30 microseconds and 35 microseconds; and

an implantable signal delivery device electrically coupleable to the signal generator and configured to be implanted within a patient's epidural space to deliver the therapy signal from the signal generator to the patient's spinal cord.

2. The system of claim 1 , wherein the current amplitude is between 0.5 and 4 mA.

3. The system of claim 1 , wherein the therapy signal includes a plurality of biphasic pulses.

4. The system of claim 1 , wherein the signal generator is an implantable signal generator.

5. The system of claim 1 , wherein the signal generator is an external signal generator.

6. The system of claim 1 , wherein the implantable signal delivery device is a percutaneous lead.

7. The system of claim 1 , wherein the implantable signal delivery device is a paddle lead.

8. The system of claim 1 , wherein the signal generator is configured to deliver the therapy signal in accordance with a duty cycle.

9. The system of claim 1 wherein the signal generator is programmed with instructions that, when executed, generate the therapy signal and deliver the therapy signal to the patient's spinal cord via the implantable signal delivery device.

10. A spinal cord modulation system, comprising:

a signal generator configured to generate a therapy signal having a frequency of 10 kHz, an amplitude between 1 mA and 6 mA, and pulses having a pulse width between 30 microseconds and 35 microseconds; and

an implantable signal delivery device configured to electrically couple to the signal generator and configured to be implanted in a patient's epidural space to deliver the therapy signal from the signal generator to the patient's spinal cord.

11. The system of claim 10 , wherein the therapy signal includes a plurality of biphasic pulses.

12. The system of claim 10 , wherein the signal generator is an implantable signal generator.

13. The system of claim 10 , wherein the signal generator is an external signal generator.

14. The system of claim 10 , wherein the implantable signal delivery device is a percutaneous lead.

15. The system of claim 10 , wherein the implantable signal delivery device is a paddle lead.

16. The system of claim 10 , wherein the signal generator is programmed with instructions that, when executed, generate the therapy signal and deliver the therapy signal to the patient's spinal cord via the implantable signal delivery device.

17. The system of claim 10 , further comprising:

a physician's programmer configured to be in wireless communication with the signal generator to remotely update signal delivery parameters of the therapy signal.

18. A spinal cord modulation system for reducing or eliminating pain in a patient, the system comprising:

a signal generator configured to generate a therapy signal in accordance with a therapy regimen, wherein at least a portion of the therapy signal is at a frequency of 10 kHz, includes pulses with pulse widths between 30 microseconds and 35 microseconds, and has a current amplitude up to 6 mA;

an implantable signal delivery device configured to electrically couple to the signal generator and configured to be implanted in the patient's epidural space to deliver the therapy signal to the patient's spinal cord; and

a programmer configured to be in wireless communication with the signal generator and configured to program the therapy regimen within the signal generator.

19. The system of claim 18 , wherein the current amplitude is between 1 mA and 6 mA.

20. The system of claim 18 , wherein the signal generator is an implantable signal generator.

21. The system of claim 18 wherein the signal generator is programmed with instructions that, when executed, generate the therapy signal and deliver the therapy signal to the patient's spinal cord via the implantable signal delivery device.

22. A spinal cord modulation system for reducing or eliminating pain in a patient, the system comprising:

a signal generator configured to generate a therapy signal in accordance with one or more therapy signal parameters;

an implantable signal delivery device configured to electrically couple to the signal generator and configured to be implanted in the patient's epidural space to deliver the therapy signal to the patient's spinal cord; and

a programmer configured to be in wireless communication with the signal generator and configured to modify at least one of the one or more therapy signal parameters in the signal generator,

wherein the one or more therapy signal parameters include, for at least a portion of the therapy signal,

(a) a frequency of 10 kHz,

(b) an amplitude up to 6 mA, and

(c) pulses with a pulse width between 30 microseconds and 35 microseconds.

23. The system of claim 22 , wherein the amplitude is between 1 mA and 6 mA.

24. The system of claim 22 , wherein the signal generator is an implantable signal generator.

25. The system of claim 22 , wherein the signal generator is an external signal generator.

26. The system of claim 22 , wherein the signal generator is programmed with instructions that, when executed, generate the therapy signal and deliver the therapy signal to the patient's spinal cord via the implantable signal delivery device.

Assignments (7)
RELEASE OF SECURITY INTEREST Recorded Apr 4, 2025
From: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT
To: NEVRO CORP.
Reel/Frame 070743/0001 →
PATENT SECURITY AGREEMENT Recorded Dec 1, 2023
From: NEVRO CORP.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT
Reel/Frame 065744/0302 →
CORRECTIVE ASSIGNMENT TO CORRECT THE RECEIVING PARTY DATA NAME PREVIOUSLY RECORDED ON REEL 034045 FRAME 0288. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Nov 21, 2016
From: ALATARIS, KONSTANTINOS; WALKER, ANDRE B.; PARKER, JON; CHITRE, YOUGANDH; PARK, SANGSOO WESLEY; THACKER, JAMES R.
To: NEVRO CORP.
Reel/Frame 040713/0476 →
RELEASE OF SECURITY INTEREST Recorded Jun 27, 2016
From: CRG SERVICING LLC
To: NEVRO CORP.
Reel/Frame 039168/0890 →
ASSIGNMENT AGREEMENT (REAFFIRMATION) Recorded Jun 13, 2016
From: CAPITAL ROYALTY PARTNERS II L.P.; CAPITAL ROYALTY PARTNERS II - PARALLEL FUND "A" L.P.; PARALLEL INVESTMENT OPPORTUNITIES PARTNERS II L.P.
To: CRG SERVICING LLC,
Reel/Frame 038984/0865 →
SECURITY INTEREST Recorded Dec 12, 2014
From: NEVRO CORP.
To: CAPITAL ROYALTY PARTNERS II L.P.; CAPITAL ROYALTY PARTNERS II - PARALLEL FUND "A" L.P.; PARALLEL INVESTMENT OPPORTUNITIES PARTNERS II L.P.
Reel/Frame 034619/0546 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 27, 2014
From: ALATARIS, KONSTANTINOS; WALKER, ANDRE B.; PARKER, JON; CHITRE, YOUGANDH; PARK, SANGSOO WESLEY; THACKER, JAMES R.
To: NEVRO CORPORATION
Reel/Frame 034045/0288 →
Continuity (5)
Continuation 14164100 · Jan 24, 2014
Continuation 12765747 · Apr 22, 2010
Provisional Application 61176868 · May 8, 2009
Provisional Application 61171790 · Apr 22, 2009
Related Publication 20150045854A1 · Feb 12, 2015