SALTS OF 2-FLUORO-N-METHYL-4-[7-(QUINOLIN-6-YL-METHYL)- IMIDAZO[1,2-B][1,2,4]TRIAZIN-2-YL]BENZAMIDE AND PROCESSES RELATED TO PREPARING THE SAME
The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and salts thereof.
1 - 34 . (canceled)
35 . A method of inhibiting tumor growth in a patient comprising administering to said patient a therapeutically effective amount of 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide dihydrochloric acid salt, or a hydrate or solvate thereof.
36 . A method of inhibiting tumor metastasis in a patient comprising administering to said patient a therapeutically effective amount of 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide dihydrochloric acid salt, or a hydrate or solvate thereof.
37 . A method of treating cancer in a patient, wherein said cancer is associated with dysregulation of the HGF/c-MET signaling pathway, comprising administering to said patient a therapeutically effective amount of 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide dihydrochloric acid salt, or a hydrate or solvate thereof.
38 . (canceled)
39 . A method of treating a cancer in a patient comprising administering to said patient a therapeutically effective amount of 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide dihydrochloric acid salt, or a hydrate or solvate thereof wherein said cancer is lung cancer, liver cancer, colorectal cancer, gastric cancer, glioblastoma, breast cancer, or cancer of the kidney.
40 - 83 . (canceled)
84 . The method of claim 39 , wherein said cancer is lung cancer.
85 . The method of claim 39 , wherein said cancer is liver cancer.
86 . The method of claim 39 , wherein said cancer is colorectal cancer.
87 . The method of claim 39 , wherein said cancer is gastric cancer.
88 . The method of claim 39 , wherein said cancer is glioblastoma.
89 . The method of claim 39 , wherein said cancer is breast cancer.
90 . The method of claim 39 , wherein said cancer is cancer of the kidney.