Disposable multivariable sensing devices having radio frequency based sensors

1. A multivariable sensing device for sensing one or more parameters of a process fluid disposed in a container, comprising:

a radio frequency based sensor configured to sense a physical parameter, a chemical parameter, a biological parameter, or combinations thereof, representative of the process fluid, wherein the radio frequency based sensor comprises:

a sensor substrate;

a radio frequency coil disposed on at least a portion of the sensor substrate; and

a support structure configured to be physically coupled to the container, wherein the support structure is configured to position the radio frequency based sensor in operative proximity to an inside of the container;

a pick-up coil disposed outside the support structure and coupled to the radio frequency based sensor; wherein the pick-up coil transmits said one or more parameters to a sensor reader; and wherein the sensor reader operatively coupled to the radio frequency based sensor.

2. The multivariable sensing device of claim 1 , wherein the radio frequency based sensor is disposed in the support structure such that at least a portion of the sensor substrate faces the inside of the container.

3. The multivariable sensing device of claim 2 , further comprising a sensing layer disposed on at least a portion of the sensor substrate.

4. The multivariable sensing device of claim 1 , wherein the radio frequency based sensor is disposed in the support structure such that at least a portion of the radio frequency coil faces the inside of the container.

5. The multivariable sensing device of claim 4 , further comprising a protection layer disposed on at least a portion of the radio frequency coil.

6. The multivariable sensing device of claim 1 , wherein at least one of the radio frequency based sensor and the support structure is disposable.

7. The multivariable sensing device of claim 1 , wherein the radio frequency based sensor is removably disposed in the support structure.

8. The multivariable sensing device of claim 1 , wherein the container is a disposable bioprocess component.

9. The multivariable sensing device of claim 8 , wherein the bioprocess component comprises one or more of a storage bag, a transfer line, a filter, a connector, a valve, a pump, a bioreactor, a separation column, or combinations thereof.

10. The multivariable sensing device of claim 1 , wherein the radio frequency based sensor is gamma-radiation sterilizable.

11. The multivariable sensing device of claim 1 , wherein the support structure comprises a body and a projection mechanically coupled to the body, and wherein the body is configured to receive the radio frequency based sensor.

12. The multivariable sensing device of claim 1 , wherein the radio frequency based sensor does not comprise a pick-up coil.

13. A method for multivariable sensing for a process fluid disposed in a container, comprising:

operatively coupling a radio frequency based sensor to a support structure to form a multivariable sensing device, wherein the radio frequency based sensor comprises:

a sensor substrate;

a radio frequency coil disposed on at least a portion of the sensor substrate;

operatively coupling the multivariable sensing device to the container;

providing a sensor reader operatively coupled to the radio frequency based sensor;

providing a pick-up coil disposed outside the support structure;

operatively coupling the pick-up coil to the radio frequency based sensor;

sensing one or more parameters from the container;

transmitting data representative of the one or more parameters to the sensor reader using the pick-up coil; and

determining one or more parameters associated with the process fluid disposed in the container.

14. The method of claim 13 , further comprising calibrating the radio frequency based sensor before or after disposing the radio frequency based sensor in the support structure.

15. The method of claim 14 , further comprising sterilizing the container and the multivariable sensing device coupled to the container prior to operatively coupling the multivariable sensing device to the container.

16. The method of claim 15 , wherein the step of sterilizing comprises sterilizing using gamma radiation.

17. The method of claim 13 , further comprising de-coupling the support from the container.

18. The method of claim 17 , further comprising re-calibrating the radio frequency based sensor, and re-coupling the support of the multivariable sensing device to the container for further use.