Devices and methods for modifying veins and other bodily vessels
The present disclosure provides, in certain aspects, unique products and methods for abrading or otherwise disrupting an interior surface of a bodily a vessel. In some forms, these products and methods further incorporate the use of one or more occluding members to be deployed in the bodily vessel in and/or around a disrupted vessel region. Abrasive endoluminal devices, in certain embodiments, exhibit a low-profile first condition for delivery into and/or through the vasculature. The device can then be transitioned to a second, expanded condition inside the vasculature for carrying out a desired abrasion. With these types of devices, the manner and design by which the device transitions from a first condition to a second condition can vary. Embodiments of such are disclosed herein.
1. A medical product for abrading an interior surface of a vascular vessel, the medical product comprising:
an endoluminally advanceable device comprising a linearly compressible segment positioned along a distal region of said device, said linearly compressible segment having a longitudinal axis, a first end, a second end, and an intermediate region occurring between said first end and said second end, said intermediate region comprising an outwardly displaceable portion configured to move outwardly toward the interior surface of the vascular vessel when said compressible segment is linearly compressed in the vessel;
said outwardly displaceable portion including one or more abrasive adaptations arranged to abrade the interior surface of the vascular vessel; and
an actuating member coupled to said compressible segment and actuatable to linearly compress said compressible segment in the vessel;
wherein said outwardly displaceable portion has a rough exterior surface relative to other portions of the endoluminally advanceable device;
wherein in an outwardly displaced configuration said outwardly displaceable portion has an outer surface having a first concave portion, a second concave portion, and a convex portion extending from the first concave portion to the second concave portion;
wherein said first concave portion has a length along said longitudinal axis and said convex portion has a length along said longitudinal axis;
wherein said length of said first concave portion is greater than said length of said convex portion; and
wherein said linearly compressible segment includes weakened portions including a plurality of joints extending along the longitudinal axis of the intermediate region of the linearly compressible segment.
2. The medical product of claim 1 , wherein said linearly compressible segment comprises a longitudinal wall segment of said distal region of said endoluminally advanceable device.
3. The medical product of claim 1 , wherein said endoluminally advanceable device has an interior surface that defines a lumen.
4. The medical product of claim 3 , wherein said actuating member is slidably received in said lumen.
5. The medical product of claim 1 , wherein said convex portion defines a curved peak and said curved peak is positioned between curved concave portions.
6. The medical product of claim 1 , wherein the actuating member is coupled to said second end of said compressible segment and actuatable relative to the first end to linearly compress said compressible segment in the vessel.
7. A medical product for abrading an interior surface of a vascular vessel, the medical product comprising:
an endoluminally advanceable device comprising a linearly compressible segment positioned along a distal region of said device, said linearly compressible segment having a longitudinal axis, a first end, a second end, and an intermediate region occurring between said first end and said second end, said intermediate region comprising an outwardly displaceable portion;
said outwardly displaceable portion including one or more abrasive adaptations effective to de-epithelialize at least a portion of a vessel wall when dragged against the vessel wall; and
an actuating member coupled to and extending proximally from said compressible segment and linearly actuatable so to linearly compress said compressible segment in the vessel;
wherein said outwardly displaceable portion is configurable between a first condition arranged for delivery through the vasculature and a second condition arranged for abrading at least a portion of the vessel wall, wherein in said second condition said outwardly displaceable portion is outwardly displaced relative to the configuration in said first condition;
wherein said outwardly displaceable portion is configured to move outwardly toward the interior surface of the vascular vessel and into said second condition when said compressible segment is linearly compressed in the vessel;
wherein in an outwardly displaced configuration said outwardly displaceable portion has an outer surface having a concave portion and a convex portion;
wherein said concave portion has a length along said longitudinal axis and said convex portion has a length along said longitudinal axis;
wherein said length of said concave portion is greater than said length of said convex portion; and
wherein said linearly compressible segment includes weakened portions including a plurality of joints extending along the longitudinal axis of the intermediate region of the linearly compressible segment.
8. The medical product of claim 7 , wherein said actuating member is actuatable to elongate said compressible segment in the vessel.
9. The medical product of claim 7 , wherein said one or more abrasive adaptations comprise abrasive particles.