Compositions and kits for the removal of irritating compounds from bodily surfaces
View Patent ↗The invention provides compositions, methods and kits for the removal of harmful or irritating substances from bodily surfaces. Kits may include a composition containing capsaicin and a capsaicin-cleansing composition, e.g., a composition in which capsaicin is soluble.
1. A method for treating pain in an individual, comprising:
a) applying to an area of the body affected by pain a first composition comprising capsaicin or a capsaicin analog in a total concentration from greater than 5% to 10% by weight of the first composition, wherein the first composition is a lotion or an emulsion; and
b) cleansing the area to which the first composition has been applied by
i) applying to the area a second, surfactant-free gel composition comprising 80 to 99 percent w/w polyethylene glycol; and
ii) wiping the second, surfactant-free gel composition from the area after the second, surfactant-free composition has been on the area for a time period sufficient to solubilize at least 10% w/w of the capsaicin or the capsaicin analog.
2. The method of claim 1 , wherein the first composition comprises capsaicin.
3. The method of claim 1 , wherein the first composition comprises a capsaicin analog.
4. The method of claim 1 , wherein the time period is one minute.
5. The method of claim 1 , wherein the pain being treated is neuropathic pain.
6. The method of claim 5 , wherein the neuropathic pain is selected from the group consisting of diabetic neuropathy, postherpetic neuralgia, HIV/AIDS, traumatic injury, complex regional pain syndrome, trigeminal neuralgia, ethrythromyalgia, and phantom pain.
7. The method of claim 1 , wherein the second, surfactant-free composition comprises:
a) 87 to 91 percent w/w of the polyethylene glycol;
b) 0.3 to 1.5 percent w/w polyacrylate thickening agent;
c) 0.01 to 0.03 percent w/w butylated hydroxyanisole;
d) 0.02 to 0.2 percent w/w disodium edetate;
e) 0.03 to 0.04 percent w/w sodium hydroxide; and
f) 9.0 to 10.0 percent w/w water.
8. The method of claim 1 , wherein the second, surfactant-free composition comprises:
a) 89.08 percent w/w of the polyethylene glycol;
b) 1.00 percent w/w polyacrylate thickening agent;
c) 0.02 percent w/w butylated hydroxyanisole;
d) 0.10 percent w/w disodium edetate;
e) 0.30 percent w/w sodium hydroxide; and
f) 9.50 percent w/w water.
9. The method of claim 1 , wherein the second, surfactant-free composition further comprises a cooling agent.
10. The method of claim 1 , further comprising administering an afferent nerve fiber blocking regional anesthetic the area of the body affected by pain.