Wound healing compositions including cyanoacrylate monomers and phenytoin
A monomeric adhesive composition includes a stabilized polymerizable monomer, such as a 1,1-disubstituted monomer, including a cyanoacrylate, and a wound healing agent, wherein the wound healing agent is 5,5-disubstitutedhydantoin, including phenytoin; and a method for making said composition.
1. A composition, comprising 2-octyl cyanoacrylate monomer, an amount of butylated hydroxyl anisole and sulfur dioxide effective to stabilize the 2-octyl cyanoacrylate monomer, and 0.05% to 0.3% by weight of the composition of phenytoin, wherein the composition is a homogeneous mixture.
2. The composition of claim 1 , wherein said composition is sterilized, and the viscosity of the sterilized composition increases between about 0% and about 40% after sterilization relative to the viscosity of the composition prior to sterilization.
3. The composition of claim 1 , further comprising up to 2000 ppm of a polymerization accelerator comprising 18-crown-6 crown ether.
4. The composition of claim 1 , further comprising a plasticizing agent selected from the group consisting of tributyl citrate, diisodecyl adipate and acetyl tributyl citrate.
5. The composition of claim 1 , further comprising a thickening agent selected from the group consisting of a partial polymer of a cyanoacrylate and a triblock copolymer of polyoxyalkylene.
6. The composition of claim 2 , wherein the composition is sterilized by irradiation.
7. The composition of claim 6 , wherein the composition is sterilized by E-beam irradiation.
8. The composition of claim 1 , wherein the composition comprises 0.1% to 0.2% by weight of the composition of phenytoin.
9. A kit, comprising an applicator and the composition of claim 1 .
10. A method of treating tissue, comprising applying the adhesive composition of claim 1 to a tissue surface, and allowing said composition to polymerize on said tissue surface.
11. A composition, comprising n-butyl cyanoacrylate monomer, an amount of butylated hydroxyl anisole and sulfur dioxide effective to stabilize the n-butyl cyanoacrylate monomer, and 0.2% to 0.8% by weight of the composition of phenytoin, wherein the composition is a homogeneous mixture.
12. The composition of claim 11 , wherein said composition is sterilized, and the viscosity of the sterilized composition increases between about 0% and about 40% after sterilization relative to the viscosity of the composition prior to sterilization.
13. The composition of claim 11 , further comprising up to 2000 ppm of a polymerization accelerator comprising 18-crown-6 crown ether.
14. The composition of claim 11 , further comprising a plasticizing agent selected from the group consisting of tributyl citrate, diisodecyl adipate and acetyl tributyl citrate.
15. The composition of claim 11 , further comprising a thickening agent selected from the group consisting of a partial polymer of a cyanoacrylate and a triblock copolymer of polyoxyalkylene.
16. The composition of claim 12 , wherein the composition is sterilized by irradiation.
17. The composition of claim 16 , wherein the composition is sterilized by E-beam irradiation.
18. The composition of claim 11 , wherein the composition comprises 0.3% to 0.5% by weight of the composition of phenytoin.
19. A kit, comprising an applicator and the composition of claim 11 .
20. A method of treating tissue, comprising applying the adhesive composition of claim 11 to a tissue surface, and allowing said composition to polymerize on said tissue surface.