Methylpyrrolopyrimidinecarboxamides

1. A method for treating idiopathic pulmonary lung fibrosis in a patient, comprising administering to said patient a therapeutically effective amount of a compound of formula (I)

wherein

R1 is —CH 2 -3-4C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, —C(O)-1-4C-alkyl or 1-4C-fluoroalkyl,

or R21 and R22 combine to form a group —O—CH 2 —O—,

R23 is hydrogen, halogen, 1-4C-alkoxy,

R24 is hydrogen,

Y is —(CH 2 ) n —,

n is 0,

R3 is a cyclohexyl or cyclopentyl group substituted by R6 and optionally substituted by R61,

R6 is —NH—C(O)—R7,

R61 is halogen or 1-4C-alkyl,

R7 is 1-4C-alkyl, which is optionally substituted by R71, or R7 is 1-4C-alkoxy,

R71 is 1-4C-alkoxy,

or a salt thereof, a stereoisomer of the compound or a salt of the stereoisomer.

2. A method for treating idiopathic pulmonary lung fibrosis in a patient, comprising administering to said patient a therapeutically effective amount of a compound of formula (I)

wherein

R1 is —CH 2 -3-4C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is difluoromethyl or trifluoromethyl,

R23 is hydrogen,

R24 is hydrogen,

Y is —(CH 2 ) n —,

n is 0,

R3 is a cyclohexyl group substituted by R6 and optionally substituted by R61,

R6 is —NH—C(O)—R7,

R61 is fluoro or methyl,

R7 is methyl or ethyl, which are optionally substituted by R71,

R71 is methoxy or hydroxy,

or a salt thereof, a stereoisomer of the compound or a salt of the stereoisomer.

3. The method of treating idiopathic pulmonary lung fibrosis in a patient according to claim 2 , comprising administering to said patient a therapeutically effective amount of a compound of formula I, wherein

R1 is —CH 2 -3-4C-cycloalkyl,

R2 is hydrogen,

R21 is hydrogen,

R22 is difluoromethyl,

R23 is hydrogen,

R24 is hydrogen,

Y is —(CH 2 )n-,

n is 0,

R3 is a cyclohexyl group substituted by R6 and optionally substituted by R61,

R6 is —NH—C(O)—R7,

R61 is fluoro or methyl,

R7 is methyl or ethyl, which are optionally substituted by R71,

R71 is methoxy or hydroxy,

or a salt thereof, a stereoisomer of the compound or a salt of the stereoisomer.

4. The method of treating idiopathic pulmonary lung fibrosis in a patient according to claim 1 , comprising administering to said patient a therapeutically effective amount of a compound which is selected from the group consisting of

N-(trans-4-acetamidocyclohexyl)-4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-6-methyl-N-[trans-4-(propionylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-{trans-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; Ethyl {trans-4-[({4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; N-(cis-4-acetamidocyclohexyl)-4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-6-methyl-N-[cis-4-(propionylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[5-(Cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-{cis-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; Ethyl {cis-4-[({4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; N-(trans-4-acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-N-[trans-4-(propionylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-{trans-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-(cis-4-acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-N-[cis-4-(propionylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluorophenyl]-N-{cis-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-(trans-4-acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-N-[trans-4-(propionylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluorophenyl]-N-{trans-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; Ethyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; N-(cis-4-acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-(trans-4-acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-(cis-4-acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-(trans-4-acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-[trans-4-(propionylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-{trans-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-(cis-4-acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-N-[cis-4-(propionylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methoxyphenyl]-N-{cis-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[trans-4-(acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-6-methyl-N-[trans-4-(propanoylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methylphenyl]-N-{trans-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[cis-4-(acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methyl phenyl]-6-methyl-N-[cis-4-(propanoylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-methyl phenyl]-N-{cis-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[trans-4-(acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methyl-N-[trans-4-(propanoylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-{trans-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[cis-4-(acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methyl-N-[cis-4-(propanoylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-{cis-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-(trans-4-Acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-N-[trans-4-(propionylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{trans-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; Ethyl {trans-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; N-(cis-4-Acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methy-N-[cis-4-(propionylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-N-{cis-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[trans-4-(Acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl-N-[trans-4-(propanoylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-{trans-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[cis-4-(Acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl-N-[cis-4-(propanoylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-N-{cis-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-(trans-4-Acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl-N-[trans-4-(propionylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-{trans-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-(cis-4-Acetamidocyclohexyl)-4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl-N-[cis-4-(propionylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-{cis-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; Ethyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; N-[trans-4-(Acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-N-[trans-4-(propanoylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-{trans-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[cis-4-(Acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-N-[cis-4-(propanoylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-ethylphenyl]-N-{cis-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[trans-4-(Acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N-{trans-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[cis-4-(Acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-N-{cis-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[trans-4-(Acetylamino)cyclohexyl]-4-[5-acetyl-2-(cyclopropylmethoxy)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-6-methyl-N-[trans-4-(propanoylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[5-Acetyl-2-(cyclopropylmethoxy)phenyl]-N-{trans-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; tert-Butyl {trans-4-[({4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-4-fluorophenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-4-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-methylphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-4-fluoro-5-methylphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-ethylphenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {cis-4-[({4-[2-(cyclopropylmethoxy)-5-(propan-2-yl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; tert-Butyl {trans-4-[({4-[2-(cyclopropylmethoxy)-5-(2-methyl-1,3-dioxolan-2-yl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]cyclohexyl}carbamate; N-[trans-4-(Acetylamino)cyclohexyl]-4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-N-[trans-4-(propanoylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{trans-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-N-[(1S,3S)-3-(propanoylamino)cyclopentyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1S,3S)-3-[(methoxyacetyl)amino]cyclopentyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[(1R*,2R*,4R*)-4-(Acetylamino)-2-fluorocyclopentyl]-4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1R*,2R*,4R*)-2-fluoro-4-(propanoylamino)cyclopentyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1R*,2R*,4R*)-2-fluoro-4-[(methoxyacetyl)amino]cyclopentyl}6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[(1S*,2S*,4S*)-4-(Acetylamino)-2-methylcyclohexyl]-4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-N-[(1S*,2S*,4S*)-2-methyl-4-(propanoylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1S*,2S*,4S*)-4-[(methoxyacetyl)amino]-2-methylcyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[(1R*,2R*,4R*)-4-(Acetylamino)-2-fluorocyclohexyl]-4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1R*,2R*,4R*)-2-fluoro-4-(propanoylamino)cyclohexyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1R*,2R*,4R*)-2-fluoro-4-[(methoxyacetyl)amino]cyclohexyl}-6-methy-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[(1S*,3S*,4S*)-4-(Acetylamino)-3-methylcyclohexyl]-4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methy-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-N-[(1S*,3S*,4S*)-3-methyl-4-(propanoylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1S*,3S*,4S*)-4-[(methoxyacetyl)amino]-3-methylcyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[(1S*,2S*,4S*)-4-(Acetylamino)-3-fluorocyclohexyl]-4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1S*,3S*,4S*)-3-fluoro-4-(propanoylamino)cyclohexyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1S*,3S*,4S*)-3-fluoro-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[(1R*,3S*,4S*)-3-(Acetylamino)-4-methylcyclopentyl]-4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-N-[(1R*,3S*,4S*)-3-methyl-4-(propanoylamino)cyclopentyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1R*,3S*,4S*)-3-[(methoxyacetyl)amino]-4-methylcyclopentyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[(1R*,2R*,4S*)-4-(acetylamino)-2-methylcyclopentyl]-4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-N-[(1R*,2R*,4S*)-2-methyl-4-(propanoylamino)cyclopentyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1R*,2R*,4S*)-4-[(methoxyacetyl)amino]-2-methylcyclopentyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[(1S*,3S*,4S*)-3-(Acetylamino)-4-fluorocyclopentyl]-4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1S*,3S*,4S*)-3-fluoro-4-(propanoylamino)cyclopentyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1S*,3S*,4S*)-3-fluoro-4-[(methoxyacetyl)amino]cyclopentyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; N-[(1S*,2R*,4S*)-4-(Acetylamino)-2-fluorocyclohexyl]-4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1S*,2R*,4S*)-2-fluoro-4-(propanoylamino)cyclohexyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1S*,2R*,4S*)-2-fluoro-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide;

salts of these compounds, stereoisomers of these compounds, and salts of the stereoisomers of these compounds.

5. The method of treating idiopathic pulmonary lung fibrosis in a patient according to claim 2 , comprising administering a therapeutically effective amount of a compound selected from the group consisting of

4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-{trans-4-[(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-(trans-4-{[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-{cis-4-[(hydroxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-[2-(Cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-N-(cis-4-{[(2S)-2-hydroxypropanoyl]amino}cyclohexyl)-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide;

salts of these compounds, stereoisomers of these compounds, and salts of the stereoisomers of these compounds.

6. The method of treating idiopathic pulmonary lung fibrosis in a patient according to claim 1 , comprising administering a therapeutically effective amount of a compound selected from the group consisting of 4-[2-(cyclopropylmethoxy)-5-(trifluoromethyl)phenyl]-6-methyl-N-[trans-4-(propanoylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide, a salt thereof, a stereoisomer of the compound and a salt of the stereoisomer.

7. The method of treating idiopathic pulmonary lung fibrosis in a patient according to claim 1 , comprising administering a therapeutically effective amount of a compound selected from the group consisting of 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-N-[trans-4-(propanoylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide, a salt thereof, a stereoisomer of the compound and a salt of the stereoisomer.

8. The method of treating idiopathic pulmonary lung fibrosis in a patient according to claim 1 , comprising administering a therapeutically effective amount of a compound selected from the group consisting of 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{trans-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide, a salt thereof, a stereoisomer of the compound and a salt of the stereoisomer.

9. The method of treating idiopathic pulmonary lung fibrosis in a patient according to claim 1 , comprising administering a therapeutically effective amount of a compound selected from the group consisting of 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-[(1R*,2R*,4R*)-2-fluoro-4-(propanoylamino)cyclohexyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide, a salt thereof, a stereoisomer of the compound and a salt of the stereoisomer.

10. The method of treating idiopathic pulmonary lung fibrosis in a patient according to claim 1 , comprising administering a therapeutically effective amount of a compound selected from the group consisting of 4-[2-(Cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{(1R*,2R*,4R*)-2-fluoro-4-[(methoxyacetyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide, a salt thereof, a stereoisomer of the compound and a salt of the stereoisomer.