β- and γ-diketones and γ-hydroxyketones as
The present application discloses a compound which is which activates Wnt/β-catenin signaling and thus treats or prevents diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries related to the differentiation and development of the central nervous system, comprising Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, comprising hair loss, hematopoiesis related diseases and tissue regeneration related diseases.
1. A compound which is
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising a compound which is
and a pharmaceutically acceptable excipient.
3. The pharmaceutical composition of claim 2 , wherein the pharmaceutically acceptable excipient is selected from the group consisting of: a polyethylene glycol, a partial glyceride mixture of saturated vegetable fatty acids, a triglyceride, a glycol, a glycerol, and mixtures thereof.
4. The pharmaceutical composition of claim 2 , wherein the composition is a solid composition.
5. The pharmaceutical composition of claim 2 , wherein the composition is a liquid composition.
6. The pharmaceutical composition of claim 2 , wherein the composition is an emulsion.
7. The pharmaceutical composition of claim 2 , wherein the composition is formulated for oral administration.
8. A topical composition comprising a compound which is
and a pharmaceutically acceptable excipient.
9. The pharmaceutical composition of claim 8 , wherein the pharmaceutically acceptable excipient is selected from the group consisting of: a polyethylene glycol, a partial glyceride mixture of saturated vegetable fatty acids, a triglyceride, a glycol, a glycerol, and mixtures thereof.
10. A method of treating alopecia in a mammal, comprising topically administering to the mammal a compound, or pharmaceutically acceptable salt thereof, having the structure of:
11. A method of treating alopecia in a mammal, comprising topically administering to the mammal a pharmaceutical composition comprising a compound, or a pharmaceutically acceptable salt thereof, having the structure of:
12. A method of promoting hair growth in a mammal, comprising topically administering to the mammal a compound, or pharmaceutically acceptable salt thereof, having the structure of:
13. A method of promoting hair growth in a mammal, comprising topically administering to the mammal a pharmaceutical composition comprising a compound, or a pharmaceutically acceptable salt thereof, having the structure of:
14. The method of claim 10 , wherein the mammal is a human.
15. The method of claim 11 , wherein the mammal is a human.
16. The method of claim 12 , wherein the mammal is a human.
17. The method of claim 13 , wherein the mammal is a human.