Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activities

1. A method of treating cancer, wherein the cancer is selected from solid tumors, gastric cancers, melanomas, glioblastomas, ovarian cancer, pancreatic cancer, prostate cancer, lung cancers, breast cancers, renal cancers, hepatic cancers, cervical carcinomas, metastasis of primary tumor sites, thyroid carcinoma, colonic cancers, the method comprising administering to a patient in need thereof an effective amount of a compound of Formula I,

or a pharmaceutically acceptable salt, enantiomer, stereoisomer or tautomer thereof, wherein:

X1 is halogen;

X2 is halogen;

Y is O, —NH;

each R1 is individually and independently halogen or H;

each R2 is individually and independently C1-C6 alkyl, deuteroC1-C6alkyl wherein the alkyl moiety can be partially or fully deuterated, C3-C8 branched alkyl, deuteroC3-C8 branched alkyl wherein the alkyl moiety can be partially or fully deuterated, or C3-C8 cycloalkyl;

R3 is C1-C6 alkyl, C3-C8 branched alkyl, C3-C8 cycloalkyl, —NR6(R7), or —R4, wherein each alkyl, branched or cycloalkyl may be optionally substituted with cyano, C1-C6alkoxy, or hydroxy;

each R4 is independently and individually selected from the group consisting of

and wherein the symbol (##) is the point of attachment of the R4 moiety;

R5 is C1-C6 alkyl;

each R6 and R7 is individually and independently H, C1-C6 alkyl, or branched C3-C8 alkyl;

n is 0, 1, or 2.

2. The method of claim 1 , wherein the compound is administered orally, parenterally, by inhalation, or subcutaneously.